Results 11 to 20 of about 100,520 (190)

Magnetic Composite Biomaterials for Neural Regeneration [PDF]

Frontiers in Bioengineering and Biotechnology, 2019
Nervous system damage caused by physical trauma or degenerative diseases can result in loss of sensory and motor function for patients. Biomaterial interventions have shown promise in animal studies, providing contact guidance for extending neurites or sustained release of various drugs and growth factors; however, these approaches often target only ...
Jessica L Funnell, Ryan J. Gilbert, Bailey Balouch   +2 more
openaire   +4 more sources

Nanomaterial-Based Approaches for Neural Regeneration [PDF]

Pharmaceutics, 2019
Mechanical, thermal, chemical, or ischemic injury of the central or peripheral nervous system results in neuron loss, neurite damage, and/or neuronal dysfunction, almost always accompanied by sensorimotor impairment which alters the patient’s life quality. The regenerative strategies for the injured nervous system are currently limited and mainly allow
Raluca Ioana Teleanu, Oana Gherasim, Tudor George Gherasim, Valentina Grumezescu, Alexandru Mihai Grumezescu, Daniel Mihai Teleanu   +5 more
openaire   +4 more sources

Spinal Progenitor-Laden Bridges Support Earlier Axon Regeneration Following Spinal Cord Injury. [PDF]

, 2018
Impact statementSpinal cord injury (SCI) results in loss of tissue innervation below the injury. Spinal progenitors have a greater ability to repair the damage and can be injected into the injury, but their regenerative potential is hampered by their ...
Anderson, Aileen J, Carlson, Mitchell A, Cummings, Brian J, Dumont, Courtney M, Munsell, Mary K, Shea, Lonnie D   +5 more
core   +1 more source

Polycistronic Delivery of IL-10 and NT-3 Promotes Oligodendrocyte Myelination and Functional Recovery in a Mouse Spinal Cord Injury Model. [PDF]

, 2020
One million estimated cases of spinal cord injury (SCI) have been reported in the United States and repairing an injury has constituted a difficult clinical challenge.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Park, Jonghyuck, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

PLG Bridge Implantation in Chronic SCI Promotes Axonal Elongation and Myelination. [PDF]

, 2019
Spinal cord injury (SCI) is a devastating condition that may cause permanent functional loss below the level of injury, including paralysis and loss of bladder, bowel, and sexual function.
Anderson, Aileen J, Ciciriello, Andrew J, Cummings, Brian J, Dumont, Courtney M, Guo, Amina, Munsell, Mary K, Shea, Lonnie D, Smith, Dominique R, Tatineni, Ravindra   +8 more
core   +1 more source

Biotargets in neural regeneration

Biotarget, 2017
The peripheral nervous system (PNS) exhibits a much larger capacity for regeneration than the central nervous system (CNS). The main reason is that the neurons in PNS still have certain intrinsic capacity for regeneration and the Schwann cells in PNS provide a suitable regeneration microenvironment.
Songlin Zhou, Hualin Sun, Qingqing Fang, Tongtong Xu, Changyue Wu   +4 more
openaire   +2 more sources

Planarian GSK3s are involved in neural regeneration [PDF]

Development Genes and Evolution, 2008
Glycogen synthase kinase-3 (GSK3) is a key element in several signaling cascades that is known to be involved in both patterning and neuronal organization. It is, therefore, a good candidate to play a role in neural regeneration in planarians. We report the characterization of three GSK3 genes in Schmidtea mediterranea. Phylogenetic analysis shows that
Teresa Adell, Emili Saló, Maria Marsal
openaire   +2 more sources

A Model for Investigating Developmental Eye Repair in Xenopus Laevis [PDF]

, 2018
Vertebrate eye development is complex and requires early interactions between neuroectoderm and surface ectoderm during embryogenesis. In the African clawed frog, Xenopus laevis, individual eye tissues such as the retina and lens can undergo regeneration.
Kha, Cindy X., Lauper, Julia, Son, Philip H., Tseng, Kelly Ai-Sun   +3 more
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Evolution of abilities to regenerate neurons in central nervous systems [PDF]

, 1980
This work was supported by a Kappa Kappa Gamma Graduate Fellowship Award to C. E. H. and NIH grant NS-11861 and RCDA NS-00070 to G. D.
Bittner, George D., Hulsebosch, C.E.
core   +1 more source

The utility of stem cells for neural regeneration [PDF]

Brain and Neuroscience Advances, 2018
The use of stem cells in biomedical research is an extremely active area of science. This is because they provide tools that can be used both in vivo and vitro to either replace cells lost in degenerative processes, or to model such diseases to elucidate their underlying mechanisms.
Kirsty Goncalves, Stefan Przyborski
openaire   +3 more sources