Results 1 to 10 of about 4,989,359 (237)
Proposed Nomenclature in the Field of Neuraminic and Sialic Acids [PDF]
Nature, 1957 IT would appear that the chemical relationship of the substances designated by various names such as neuraminic, sialic, lactiminic and gynaminic acid has been established. In order to avoid further confusion we propose to call the basic, unsubstituted compound neuraminic acid.
Alfred Gottschalk, F. G. Blix, E. Klenk
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Glycolyl-neuraminic Acid in Ox Brain Gangliosides [PDF]
Nature, 1965 IN this communication we report the presence of glycolyl-neuraminic acid in sialic acids from ox brain gangliosides. Our method of analysis consisted of the following six steps: (i) gangliosides were extracted from ox brain grey matter and purified according to a method which we have previously described1; (ii) gangliosides so obtained were hydrolysed ...
G Tettamanti +3 more
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Origin of Neuraminic Acid in Human Seminal Fluid [PDF]
Nature, 1964 THE occurrence and possible function of the neuraminic acids in mammalian tissues and fluids is a matter of great interest. Large amounts of N-acetylneuraminic acid have been demonstrated in the seminal fluid of man1,2, bull3 and boar4. Analysis of the secretions of the accessory genital organs of the boar showed that the mucin from the bulbourethral ...
Rune Eliasson
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Recent Advances in Enzymes and Chemoenzymatic Synthesis of Tetrasaccharide Linkage Region of Proteoglycans [PDF]
ChemBioChem, Volume 26, Issue 10, May 27, 2025.The tetrasaccharide linkage region of proteoglycans is synthesized through a series of well‐controlled enzymatic reactions in nature. The expression, activity, and substrate profile of these biosynthetic enzymes and the latest development of chemoenzymatic synthesis of linkage region‐bearing glycopeptides are summarized in this review.
Po‐han Lin, Xuefei Huang
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Neuraminic Acid as a Constituent of Human Cerebrospinal Fluid.
Experimental Biology and Medicine, 1956 Conclusions1. The neuraminic acid (NA) content of 49 samples of human cerebrospinal fluid (CSF) was studied. In all instances the quantitative relationship of neuraminic acid to the cerebrospinal fluid protein was far in excess of that prevalent in serum.
Marilynn K. Rumley, L. Lahut Uzman
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Neuraminic acid content of sputum in chronic bronchitis [PDF]
Thorax, 1972 The neuraminic acid content of sputum from 48 men with early chronic bronchitis has been estimated in samples collected over a period of three years. The results are compared with those from 29 advanced bronchitic patients and are related to the clinical features of both groups and to the physical and biological properties of the sputum.
Lynne Reid, E. E. Keal
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Koenigs-Knorr Glycosylation with Neuraminic Acid Derivatives [PDF]
International Journal of Carbohydrate Chemistry, 2010 Earlier we reported a convenient and efficient method of preparing α2-6 sialooligosaccharides in conditions of Koenigs-Knorr reaction. The use of Ag2CO3 allowed carrying out α2-6 sialylation of galacto-4,6-diol of mono- and disaccharides with chloride of acetylated N-acetylneuraminic acid methyl ester as glycosyl donor.
Galina V. Pazynina +6 more
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ChemMedChem, EarlyView.This article describes the development of improved NEU1 inhibitors based on the 2‐deoxy‐2,3‐didehydro‐N‐acetyl neuraminic acid scaffold. A series of candidate inhibitors are designed containing bioisosteres of the C5‐amide group and evaluated for activity against NEU1‐4 enzymes.
Mostafa Radwan +2 more
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The FEBS Journal, EarlyView.Modification of the glycocalyx via ‘glycan editing’ is distinguishable from ‘glycan‐motif editing’. The former broadly remodels the glycocalyx, whereas the latter inhibits expression only of a specific oligosaccharide motif within the glycocalyx by selectively dampening the bioactivity of the key glycosyltransferase(s) programming the biosynthesis of ...
Barbara Richichi, Robert Sackstein
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Advanced Science, Volume 12, Issue 18, May 15, 2025.Enzymatic introduction of azido‐sialic acid residues to the glycans on exosomes enables a new and efficient approach for exosomal functionalization with various probes, including biotin and fluorophores, by biocompatible click chemistry, thereby facilitating detailed investigations of exosomes, such as their glycan profiles, cellular uptake, etc., and ...
Sayan Kundu +5 more
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