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NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?

MBio, 2018
Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. It has enzymatic activity that cleaves terminal sialic acid from glycans, and that activity is essential at several points in the virus life cycle. While neuraminidase is
Florian H Krammer, Ron A M Fouchier, Hongquan Wan   +2 more
exaly   +3 more sources

Optimisation of Neuraminidase Expression for Use in Drug Discovery by Using HEK293-6E Cells

Viruses, 2021
Influenza virus is a highly contagious virus that causes significant human mortality and morbidity annually. The most effective drugs for treating influenza are the neuraminidase inhibitors, but resistance to these inhibitors has emerged, and additional ...
Ashley C. Campbell, John J. Tanner, Kurt L. Krause   +2 more
doaj   +1 more source

Influenza Neuraminidase Characteristics and Potential as a Vaccine Target

Frontiers in Immunology, 2021
Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity ...
Sarah Creytens, Sarah Creytens, Mirte N. Pascha, Marlies Ballegeer, Marlies Ballegeer, Xavier Saelens, Xavier Saelens, Cornelis A. M. de Haan   +7 more
doaj   +1 more source

Pharmacoinformatics and Breed-Based De Novo Hybridization Studies to Develop New Neuraminidase Inhibitors as Potential Anti-Influenza Agents

Molecules, 2023
Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza.
Bourougaa Lotfi, Ouassaf Mebarka, Bader Y. Alhatlani, Emad M. Abdallah, Sarkar M. A. Kawsar   +4 more
doaj   +1 more source

A Novel Recombinant Influenza Virus Neuraminidase Vaccine Candidate Stabilized by a Measles Virus Phosphoprotein Tetramerization Domain Provides Robust Protection from Virus Challenge in the Mouse Model

mBio, 2021
Current seasonal influenza virus vaccines do not induce robust immune responses to neuraminidase. Several factors, including immunodominance of hemagglutinin over neuraminidase, instability of neuraminidase in vaccine formulations, and variable ...
Shirin Strohmeier, Fatima Amanat, Xueyong Zhu, Meagan McMahon, Meagan E. Deming, Marcela F. Pasetti, Kathleen M. Neuzil, Ian A. Wilson, Florian Krammer   +8 more
doaj   +1 more source

Pneumococcal Neuraminidase [PDF]

Journal of Bacteriology, 1966
Lee, L. T. (Columbia University, New York, N.Y.),and C. Howe. Pneumoccal neuraminidase. J. Bacteriol.91:1418–1426. 1966.—The elaboration of neuraminidase by pneumococci grown under optimal conditions in liquid medium was studied in relation to the bacterial growth cycle.
L T, Lee, C, Howe
openaire   +2 more sources

Boost immunizations with NA-derived peptide conjugates achieve induction of NA inhibition antibodies and heterologous influenza protections

Cell Reports, 2023
Summary: Neuraminidase is suggested as an important component for developing a universal influenza vaccine. Targeted induction of neuraminidase-specific broadly protective antibodies by vaccinations is challenging.
De-Jian Liu, Cui-Cui Liu, Xiu-Qin Zhong, Xuan Wu, Hui-Hui Zhang, Shang-Wen Lu, Zhuo-Ling Shen, Wen-Wen Song, Shi-Long Zhao, You-Song Peng, He-Ping Zheng, Mu-Yang Wan, Yao-Qing Chen, Lei Deng   +13 more
doaj   +1 more source

Potential of Neuraminidase from Pasteurella multocida for Inhibiting Avian Influenza Virus Subtype H9N2 Replication In Ovo

Tropical Animal Science Journal, 2023
In recent decades, neuraminidase/sialidase-based antivirals have been produced to suppress respiratory viral infections, including avian influenza, which relies on sialic acid as the entry point for viruses into cells.
O. N. Poetri, C. M. H. Nugroho, O. S. M. Silaen, R. S. Kurnia, D. G. B. Krisnamurti, A. Indrawati, N. Hikmah, I. P. P. K. Hariyadi, M. A. Putra, A. Soebandrio   +9 more
doaj   +1 more source

Mucosal Immunity against Neuraminidase Prevents Influenza B Virus Transmission in Guinea Pigs

mBio, 2019
Despite efforts to control influenza virus infection and transmission, influenza viruses still cause significant morbidity and mortality in the global human population each year.
Meagan McMahon, Ericka Kirkpatrick, Daniel Stadlbauer, Shirin Strohmeier, Nicole M. Bouvier, Florian Krammer   +5 more
doaj   +1 more source

A computational-experimental approach identifies mutations that enhance surface expression of an oseltamivir-resistant influenza neuraminidase. [PDF]

PLoS ONE, 2011
The His274→Tyr (H274Y) oseltamivir (Tamiflu) resistance mutation causes a substantial decrease in the total levels of surface-expressed neuraminidase protein and activity in early isolates of human seasonal H1N1 influenza, and in the swine-origin ...
Jesse D Bloom, Jagannath S Nayak, David Baltimore   +2 more
doaj   +1 more source