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Influenza Neuraminidase Characteristics and Potential as a Vaccine Target
Frontiers in Immunology, 2021 Neuraminidase of influenza A and B viruses plays a critical role in the virus life cycle and is an important target of the host immune system. Here, we highlight the current understanding of influenza neuraminidase structure, function, antigenicity ...
Sarah Creytens +7 more
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mBio, 2021 Current seasonal influenza virus vaccines do not induce robust immune responses to neuraminidase. Several factors, including immunodominance of hemagglutinin over neuraminidase, instability of neuraminidase in vaccine formulations, and variable ...
Shirin Strohmeier +8 more
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NAction! How Can Neuraminidase-Based Immunity Contribute to Better Influenza Virus Vaccines?
mBio, 2018 Neuraminidase is one of the two surface glycoproteins of influenza A and B viruses. It has enzymatic activity that cleaves terminal sialic acid from glycans, and that activity is essential at several points in the virus life cycle. While neuraminidase is
Florian Krammer +9 more
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Mucosal Immunity against Neuraminidase Prevents Influenza B Virus Transmission in Guinea Pigs
mBio, 2019 Despite efforts to control influenza virus infection and transmission, influenza viruses still cause significant morbidity and mortality in the global human population each year.
Meagan McMahon +5 more
doaj +2 more sources
mBio, 2017 Antibody responses to influenza virus hemagglutinin provide protection against infection and are well studied. Less is known about the human antibody responses to the second surface glycoprotein, neuraminidase. Here, we assessed human antibody reactivity
Madhusudan Rajendran +9 more
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Influenza Neuraminidase Inhibitors: Synthetic Approaches, Derivatives and Biological Activity
Molecules, 2016 Despite being a common viral disease, influenza has very negative consequences, causing the death of around half a million people each year. A neuraminidase located on the surface of the virus plays an important role in viral reproduction by contributing
Pedro Laborda +2 more
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Optimisation of Neuraminidase Expression for Use in Drug Discovery by Using HEK293-6E Cells
Viruses, 2021 Influenza virus is a highly contagious virus that causes significant human mortality and morbidity annually. The most effective drugs for treating influenza are the neuraminidase inhibitors, but resistance to these inhibitors has emerged, and additional ...
Ashley C. Campbell +2 more
doaj +1 more source
A pan-influenza antibody inhibiting neuraminidase via receptor mimicry
Nature, 2023 The neuraminidase-targeting monoclonal antibody FNI9 potently inhibits the enzymatic activity of influenza A and B viruses via receptor mimicry. Rapidly evolving influenza A viruses (IAVs) and influenza B viruses (IBVs) are major causes of recurrent ...
Corey Momont +34 more
semanticscholar +1 more source
Neuraminidase 1 promotes renal fibrosis development in male mice
Nature Communications, 2023 The functions of the influenza virus neuraminidase has been well documented but those of the mammalian neuraminidases remain less explored. Here, we characterize the role of neuraminidase 1 (NEU1) in unilateral ureteral obstruction (UUO) and folic acid ...
Qian-qian Chen +13 more
semanticscholar +1 more source
Molecules, 2023 Influenza represents a profoundly transmissible viral ailment primarily afflicting the respiratory system. Neuraminidase inhibitors constitute a class of antiviral therapeutics employed in the management of influenza.
Bourougaa Lotfi +4 more
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