RTEL1 gene polymorphisms and neuroblastoma risk in Chinese children
BMC Cancer, 2023 Background Neuroblastoma, a neuroendocrine tumor originating from the sympathetic ganglia, is one of the most common malignancies in childhood. RTEL1 is critical in many fundamental cellular processes, such as DNA replication, DNA damage repair, genomic ...
Ting Zhang +5 more
doaj +1 more source
Polyphenon E enhances the antitumor immune response in neuroblastoma by inactivating myeloid suppressor cells [PDF]
, 2013 This is the author's accepted manuscript. The final published article is available from the link below. Note: In this manuscript as well as in the original published version of this article the word "Polyphenon" was incorrectly spelled in the title as ...
Adrian J. Thrasher +14 more
core +2 more sources
Nature Communications, 2021 Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. Here we study single-cell and single-nuclei transcriptomes of
O. Bedoya-Reina +15 more
semanticscholar +1 more source
Identification and pharmacological inactivation of the MYCN gene network as a therapeutic strategy for neuroblastic tumor cells [PDF]
, 2015 This research was originally published in Journal of Biological Chemistry. Olesya Chayka, Cosimo Walter D’Acunto, Odette Middleton, Maryam Arab, and Arturo Sala.
Arab, M +4 more
core +1 more source
Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Journal of Clinical Investigation, 2018 High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism.
Behrouz Hassannia +24 more
semanticscholar +1 more source
Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma
Nature Communications, 2020 MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA).
K. Helmsauer +28 more
semanticscholar +1 more source
EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth.
PLoS ONE, 2021 Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival.
Laura V Bownes +11 more
doaj +1 more source
Chemoresistance acquisition induces a global shift of expression of aniogenesis-associated genes and increased pro-angogenic activity in neuroblastoma cells [PDF]
, 2009 BACKGROUND: Chemoresistance acquisition may influence cancer cell biology. Here, bioinformatics analysis of gene expression data was used to identify chemoresistance-associated changes in neuroblastoma biology.
Barth, Susanne +10 more
core +6 more sources
Tumor to normal single-cell mRNA comparisons reveal a pan-neuroblastoma cancer cell
Science Advances, 2021 Comparisons of neuroblastoma cells and relevant normal adrenal cells reveal a uniform cell state that characterizes neuroblastoma. Neuroblastoma is a childhood cancer that resembles developmental stages of the neural crest.
Gerda Kildisiute +38 more
semanticscholar +1 more source
Anesthetic management of an infant with giant abdominal neuroblastoma
Brazilian Journal of Anesthesiology, 2017 Neuroblastoma is the most common, non-central nervous system tumor of childhood. It has the potential to synthesize catecholamines. However, the presences of hypertension are uncommon.
Manuel Ángel Gómez-Ríos +2 more
doaj +1 more source