Results 31 to 40 of about 268,028 (214)

Integrating Bulk-seq and Single-cell-seq Reveals Estrogen and MAPK Pathways Associating with Neuroblastoma Outcome

Cancer Control, 2023
Introduction Neuroblastoma is the most common extracranial solid tumor in children. Patients with high-risk neuroblastoma have a 5-year survival rate less than 50% after extensive treatment. Signaling pathways control cell fate decisions that dictate the
Xin Li, Yanlong Zheng, Qiao Ge, Zhenbo Dai, Dejun Zhou, Xiangdong Tian   +5 more
doaj   +1 more source

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Journal of Clinical Investigation, 2018
High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural ferroptosis-inducing agent in neuroblastoma, which acts through a novel double-edged mechanism.
Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, F. Qu, Simon Van Herck, Y. Tyurina, H. Bayır, B. A. Abhari, J. Angeli, Sze Men Choi, Eline Meul, K. Heyninck, K. Declerck, C. S. Chirumamilla, M. Lahtela-Kakkonen, G. Van Camp, D. Krysko, P. Ekert, S. Fulda, B. D. De Geest, M. Conrad, V. Kagan, W. Vanden Berghe, P. Vandenabeele, T. Vanden Berghe   +24 more
semanticscholar   +1 more source

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma [PDF]

, 2009
Current treatment options for neuroblastoma fail to eradicate the disease in the majority of high-risk patients, clearly mandating development of innovative therapeutic strategies. Gene therapy represents a promising approach for reversing the neoplastic
Ardelt, Arnold, Beck, Benito, Brodeur, Chan, Cinatl, Cinatl, D'Alessio, Hellemans, Holmes, Jasty, Kotchetkov, Lebedeva, Lebedeva, Leszczyniecka, Leszczyniecka, Maris, McConville, Michaelis, Pattyn, Pattyn, Ross, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Su, Tweddle, Van Maerken, Vandesompele, Vandesompele, Vasandani, Vasandani, Youle, Young   +37 more
core   +2 more sources

miR‐100 rs1834306 a > G polymorphism decreases neuroblastoma risk in Chinese children

Cancer Reports, 2023
Background Neuroblastoma is a common malignant tumor stemming from the sympathetic nervous system in children, which is often life‐threatening. The genetics of neuroblastoma remains unclear. Studies have shown that miRNAs participate in the regulation of
Yufeng Han, Jiaming Chang, Lei Lin, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He, Wen Fu   +7 more
doaj   +1 more source

Enhancer hijacking determines extrachromosomal circular MYCN amplicon architecture in neuroblastoma

Nature Communications, 2020
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA (ecDNA).
K. Helmsauer, Maria E. Valieva, Salaheddine Ali, R. Chamorro González, R. Schöpflin, Claudia Röefzaad, Yi Bei, H. Dorado García, Elias Rodriguez-Fos, Montserrat Puiggrós, K. Kasack, K. Haase, Csilla Keskeny, Celine Y. Chen, L. P. Kuschel, P. Euskirchen, V. Heinrich, Michael I. Robson, Carolina Rosswog, J. Toedling, A. Szymansky, F. Hertwig, M. Fischer, D. Torrents, A. Eggert, J. Schulte, S. Mundlos, A. Henssen, R. Koche   +28 more
semanticscholar   +1 more source

Single-nuclei transcriptomes from human adrenal gland reveal distinct cellular identities of low and high-risk neuroblastoma tumors

Nature Communications, 2021
Childhood neuroblastoma has a remarkable variability in outcome. Age at diagnosis is one of the most important prognostic factors, with children less than 1 year old having favorable outcomes. Here we study single-cell and single-nuclei transcriptomes of
O. Bedoya-Reina, W. Li, M. Arceo, M. Plescher, P. Bullova, H. Pui, M. Kaucká, P. Kharchenko, T. Martinsson, J. Holmberg, I. Adameyko, Q. Deng, C. Larsson, C. Juhlin, P. Kogner, S. Schlisio   +15 more
semanticscholar   +1 more source

Hypoxia in the Initiation and Progression of Neuroblastoma Tumours [PDF]

, 2020
Neuroblastoma is the most frequent extracranial solid tumour in children, causing 10% of all paediatric oncology deaths. It arises in the embryonic neural crest due to an uncontrolled behaviour of sympathetic nervous system progenitors, giving rise to ...
Gómez Muñoz, María Ángeles, Huertas Castaño, Carlos, Pardal Redondo, Ricardo, Vega Moreno, Francisco Manuel   +3 more
core   +1 more source

Pyroptosis-Related Gene Signature Predicts the Prognosis and Immune Infiltration in Neuroblastoma

Frontiers in Genetics, 2022
Neuroblastoma is the most common pediatric extracranial solid tumor. The 5-year survival rate for high-risk neuroblastoma is less than 50%, despite multimodal treatment.
Wanrong Li, Xin Li, Yuren Xia, Jian Wang
doaj   +1 more source

Tau affects P53 function and cell fate during the DNA damage response [PDF]

Communications Biology 3, 245 (2020), 2020
Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and ...
arxiv   +1 more source

Action of HMGB1 on miR221/222 cluster in neuroblastoma cell lines [PDF]

, 2016
microRNA (miR/miRNA) are small non-coding RNAs that control gene expression at the post-transcriptional level by targeting mRNAs. Aberrant expression of miRNAs is often observed in different types of cancer.
Fico, F, Mardente, Stefania, Mari, Emanuela, Martina, L, Massimi, Isabella, Zicari, Alessandra   +5 more
core   +1 more source