Results 1 to 10 of about 28,344 (85)
Il-10 signaling reduces survival in mouse models of synucleinopathy
npj Parkinson's Disease, 2021 Parkinson’s disease (PD) and related synucleinopathies are characterized by chronic neuroinflammation leading to the premise that anti-inflammatory therapies could ameliorate synucleinopathy and associated sequelae. To test this idea, we used recombinant
Samuel G. Cockey +12 more
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Acta Neuropathologica Communications, 2023 Apolipoprotein (APOE) E4 isoform is a major risk factor of Alzheimer’s disease and contributes to metabolic and neuropathological abnormalities during brain aging.
Tristan Williams +10 more
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NEURODEGENERATIVE DISEASES [PDF]
Neuroimaging Clinics of North America, 2001 This article briefly discusses and illustrates the major important neurodegenerative diseases of adulthood and neurometabolic (neurodegenerative in a broader sense) diseases of childhood and their gross neuropathology. Macroscopic views of the brain including the cerebellum and the brain stem and the spinal cord are given by external inspection as well
H H, Goebel, J, Bohl, W, Müller-Forell
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Impact of APOE genotype on prion-type propagation of tauopathy
Acta Neuropathologica Communications, 2022 Apolipoprotein (APOE) is a major risk factor of Alzheimer’s disease (AD), with the E2, E3 and E4 isoforms differentially regulating the burden of AD-associated neuropathologies, such as amyloid β and tau.
Tristan Williams +10 more
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Long non-coding RNAs in brain tumors: roles and potential as therapeutic targets
Journal of Hematology & Oncology, 2021 Brain tumors are associated with adverse outcomes despite improvements in radiation therapy, chemotherapy, and photodynamic therapy. However, treatment approaches are evolving, and new biological phenomena are being explored to identify the appropriate ...
Sung-Hyun Kim +3 more
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Molecular Neurodegeneration, 2021 Background There is an association between repetitive head injury (RHI) and a pathologic diagnosis of chronic traumatic encephalopathy (CTE) characterized by the aggregation of proteins including tau.
Laura Gutierrez-Quiceno +11 more
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Alzheimer’s Research & Therapy, 2022 Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinating new theory for the pathophysiology of ...
Andrea Arighi +12 more
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Scientific Reports, 2021 An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Michael R. Strickland +5 more
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Aquaporins and Neurodegenerative Diseases [PDF]
Current Neuropharmacology, 2010 Aquaporins (AQPs) are a family of widely distributed membrane-inserted water channel proteins providing a pathway for osmotically-driven water, glycerol, urea or ions transport through cell membranes and mechanisms to control particular aspects of homeostasis.
Foglio E, RODELLA, Luigi Fabrizio
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Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau
Acta Neuropathologica Communications, 2023 Distinctive post-translational modifications (PTM) characterize tau inclusions found in tauopathy patients. Using detergent-insoluble tau isolated from Alzheimer’s disease (AD-tau) or Progressive Supranuclear Palsy (PSP-tau) patients, we provide insights
Ethan D. Smith +5 more
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