Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction [PDF]
Frontiers in Endocrinology, 2021 Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama +4 more
doaj +3 more sources
Effects of electroacupuncture on the kisspeptin-gonadotropin-releasing hormone (GnRH) /luteinizing hormone (LH) neural circuit abnormalities and androgen receptor expression of kisspeptin/neurokinin B/dynorphin neurons in PCOS rats [PDF]
J Ovarian Res, 2023 Background Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, anovulation, and polycystic ovaries. Electroacupuncture (EA) can effectively improve hyperandrogenism and increase ovulation frequency in patients with PCOS.
Ge Xu +6 more
semanticscholar +3 more sources
Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep [PDF]
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
doaj +3 more sources
Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats [PDF]
The Journal of Reproduction and Development, 2021 Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic gonadotropin-releasing hormone (GnRH) pulse generator.
Yoshihiro WAKABAYASHI +2 more
doaj +3 more sources
Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates [PDF]
Frontiers in Endocrinology, 2018 In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty.
Ei Terasawa +4 more
doaj +3 more sources
The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B
Endocr Rev, 2023 Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive
B. Patel +6 more
semanticscholar +2 more sources
The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs [PDF]
J Neuroendocrinol, 2022 Undernutrition limits reproduction through inhibition of gonadotropin‐releasing hormone (GnRH)/luteinizing hormone (LH) secretion. Because KNDy neurons coexpress neuropeptides that play stimulatory (kisspeptin and neurokinin B [NKB]) and inhibitory ...
K. Harlow +7 more
semanticscholar +2 more sources
Decreased neurokinin B as a risk factor of functional hypothalamic amenorrhea
Gynecological Endocrinology, 2023 Background Neurokinin B (NKB) belongs to the tachykinin family of proteins who’s regulation is essential for proper function of the reproductive system.
Anna Szeliga +3 more
doaj +2 more sources
Romanian Medical Journal, 2021 Hot flashes (HF), transitory episodes of erythema, heat sensation, anxiety followed by chills, are described in carcinoid syndrome, mastocytosis, medullary thyroid cancer, hyperthyroidism, pheochromocytoma, alcohol consumption, side effects of drugs, and
Florica Sandru +7 more
doaj +1 more source
Performance deficits of NK1 receptor knockout mice in the 5 choice serial reaction time task: effects of d Amphetamine, stress and time of day. [PDF]
, 2011 Background The neurochemical status and hyperactivity of mice lacking functional substance P-preferring NK1 receptors (NK1R-/-) resemble abnormalities in Attention Deficit Hyperactivity Disorder (ADHD).
A Blokland +73 more
core +11 more sources