Effect of neurokinin B and dynorphin A on kisspeptin-10 secretion from the anterior pituitary cells of pubescent ewes in vitro [PDF]
Journal of Veterinary ResearchNeurokinin B (NKB), dynorphin A (Dyn A) and kisspeptin (KiSS) are key agents that participate in the neuroendocrine regulation of the development and functioning of the reproductive system.
Szysiak Natalia +5 more
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Neurokinin B and pre-eclampsia: a decade of discovery [PDF]
Reproductive Biology and Endocrinology, 2010 At the start of the last decade, we provided evidence that levels of the peptide neurokinin B were highly elevated in pre-eclampsia. We hypothesized that elevated levels of neurokinin B may be an indicator of pre-eclampsia and that treatment with certain
Page Nigel M
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Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates [PDF]
Frontiers in Endocrinology, 2018 In human patients, loss-of-function mutations in the genes encoding kisspeptin (KISS1) and neurokinin B (NKB) and their receptors (KISS1R and NK3R, respectively) result in an abnormal timing of puberty or the absence of puberty.
Ei Terasawa +4 more
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Role of KNDy Neurons Expressing Kisspeptin, Neurokinin B, and Dynorphin A as a GnRH Pulse Generator Controlling Mammalian Reproduction [PDF]
Frontiers in Endocrinology, 2021 Increasing evidence accumulated during the past two decades has demonstrated that the then-novel kisspeptin, which was discovered in 2001, the known neuropeptides neurokinin B and dynorphin A, which were discovered in 1983 and 1979, respectively, and ...
Yoshihisa Uenoyama +4 more
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Essential Role of Histidine for Rapid Copper(II)-Mediated Disassembly of Neurokinin B Amyloid [PDF]
Biomolecules, 2022 Neurokinin B is a tachykinin peptide involved in a diverse range of neuronal functions. It rapidly forms an amyloid, which is considered physiologically important for efficient packing into dense core secretory vesicles within hypothalamic neurons ...
Bhawantha M. Jayawardena +3 more
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Gastroenterologìa, 2023 Background. The study of neuropeptides, including substance P, neurokinins, may reveal possible mechanisms of the progression of gastrointestinal lesions with the formation of motility disorders in patients with coronavirus disease 2019 (COVID-19 ...
Ye.S. Sirchak, A.V. Stehura
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Local administration of Neurokinin B in the arcuate nucleus accelerates the neural activity of the GnRH pulse generator in goats [PDF]
The Journal of Reproduction and Development, 2021 Kisspeptin neurons in the arcuate nucleus (ARC), which co-express neurokinin B (NKB) and dynorphin A, are termed KNDy neurons. These neurons are candidates for the intrinsic gonadotropin-releasing hormone (GnRH) pulse generator.
Yoshihiro WAKABAYASHI +2 more
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Assessing the effects of menopause and obesity on matriptase-2 and neurokinin B concentrations: A cross-sectional study [PDF]
Journal of Medical BiochemistryBackground: Matriptase-2 (MT2) is implicated in iron metabolism, obesity, insulin resistance, and glucose homeostasis. Neurokinin B (NKB) plays a crucial role in gonadotropin secretion, which is essential for reproduction.
Bulut Arikan Funda, Sagsoz Nevin
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Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep [PDF]
Biology, 2021 The neural mechanisms underlying increases in gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) secretion that drive puberty onset are unknown.
Eliana G. Aerts +6 more
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Expression of Neurokinin B Receptor in the Gingival Squamous Cell Carcinoma Bone Microenvironment [PDF]
Diagnostics, 2021 Gingival squamous cell carcinoma (SCC) frequently invades the maxillary or mandibular bone, and bone destruction is known as a key prognostic factor in gingival SCCs.
Shoko Yoshida +9 more
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