Results 51 to 60 of about 11,252 (195)

Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats

The Journal of Reproduction and Development, 2023
Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse ...
Takashi YAMAMURA, Hiroaki OKAMURA, Yoshihiro WAKABAYASHI   +2 more
doaj   +1 more source

Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study

Pakistan Armed Forces Medical Journal
Objective: To investigate the potential of variable doses of Neurokinin B on histomorphology of epididymis in adult rabbits. Study Design: Laboratory-based experimental study.
Faiqah Ramzan, Ramsha Zahra, Muhammad Haris Ramzan   +2 more
doaj   +1 more source

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source

Alteration of Neurokinin B Gene Expression and Hypothalamic-Pituitary- Gonadal Axis in Response to One-month Regular Moderate Physical Activity [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: The advantageous effects of the regular moderate physical activity (Exercise) on reproduction is widely accepted, but until now, the alterations of the expression of hypothalamic arcuate nuclei gene affecting on reproduction axis in response ...
Nazli Khajehnasiri, Homayoun Khazali, Farzam Sheikhzadeh Hesari   +2 more
doaj  

Beyond leptin: emerging candidates for the integration of metabolic and reproductive function during negative energy balance

Frontiers in Endocrinology, 2011
Reproductive status is tightly coupled to metabolic state in females, and ovarian cycling in mammals is halted when energy output exceeds energy input, a metabolic condition known as negative energy balance.
Cadence eTrue, Kevin eGrove, M Susan eSmith   +2 more
doaj   +1 more source

The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.

Endocr Rev, 2023
Abstract Kisspeptin (KP) and neurokinin B (NKB) are neuropeptides that govern the reproductive endocrine axis through regulating hypothalamic gonadotropin-releasing hormone (GnRH) neuronal activity and pulsatile GnRH secretion. Their critical role in reproductive health was first identified after inactivating variants in genes encoding ...
Patel B, Koysombat K, Mills EG, Tsoutsouki J, Comninos AN, Abbara A, Dhillo WS.   +6 more
europepmc   +3 more sources

Neurokinin B signalling in the human reproductive axis

Molecular and Cellular Endocrinology, 2011
Recent human genetic studies have established that neurokinin B (NKB) signalling via the neurokinin 3 receptor (NK3R) is required for normal developmental activation of pulsatile GnRH secretion from the hypothalamus. As increasing numbers of patients with loss-of-function mutations have been described, evidence has emerged that peripheral NKB is not ...
Topaloglu, A. Kemal, Semple, Robert K.
openaire   +3 more sources

Leukocyte Recruitment to Peritoneal Cavity of Rats Following Formalin Injection: Role of Tachykinin Receptors

Journal of Pharmacological Sciences, 2004
The aim of this work was to verify whether formalin would induce leukocyte recruitment following intraperitoneal (i.p.) injection in rats. Formalin (1.25 – 2.5%) induced cell recruitment, which was concentration- and time-dependent (0 – 24 h).
Júlia M.M. Santos, Maria Aparecida K.F. Tatsuo, Regina Maria M. Turchetti-Maia, Marcela C.G. Lisboa, Janetti N. de Francischi   +4 more
doaj   +1 more source

GPR54-dependent stimulation of luteinizing hormone secretion by neurokinin B in prepubertal rats. [PDF]

PLoS ONE, 2012
Kisspeptin, neurokinin B (NKB) and dynorphin A (Dyn) are coexpressed within KNDy neurons that project from the hypothalamic arcuate nucleus (ARC) to GnRH neurons and numerous other hypothalamic targets.
Pasha Grachev, Xiao Feng Li, Yuan Shao Lin, Ming Han Hu, Leena Elsamani, Stewart J Paterson, Robert P Millar, Stafford L Lightman, Kevin T O'Byrne   +8 more
doaj   +1 more source

Neurokinin Bs and neurokinin B receptors in zebrafish-potential role in controlling fish reproduction [PDF]

Proceedings of the National Academy of Sciences, 2012
The endocrine regulation of vertebrate reproduction is achieved by the coordinated actions of several peptide neurohormones, tachykinin among them. To study the evolutionary conservation and physiological functions of neurokinin B (NKB), we identified tachykinin (tac) andtac receptor(NKBR) genes from many fish species, and cloned two cDNA forms from ...
Jakob, Biran, Ori, Palevitch, Shifra, Ben-Dor, Berta, Levavi-Sivan   +3 more
openaire   +2 more sources