Results 71 to 80 of about 12,605,538 (213)

State-Dependent and -Independent Effects of Dialyzing Excitatory Neuromodulator Receptor Antagonists into the Ventral Respiratory Column [PDF]

, 2017
Unilateral dialysis of the broad-spectrum muscarinic receptor antagonist atropine (50 mM) into the ventral respiratory column [(VRC) including the pre-Bötzinger complex region] of awake goats increased pulmonary ventilation (V̇i) and breathing frequency (
Burgraff, Nicholas J., Crumley, Emma, Forster, Hubert V., Hodges, Matthew R., Langer, Thomas M., III, Neumueller, Suzanne E., Pan, Lawrence, Talwar, Sawan   +7 more
core   +2 more sources

The effects of supraphysiological levels of testosterone on neural networks upstream of gonadotropin-releasing hormone neurons [PDF]

Iranian Journal of Basic Medical Sciences, 2019
Objective(s): Several pathological conditions are associated with hyper-production of testosterone; however, its impacts are not well understood. Hence, we evaluated the effects of supraphysiological levels of testosterone on gonadotropin-releasing ...
Mohammad Saied Salehi, Homayoun Khazali, Fariba Mahmoudi, Mahyar Janahmadi   +3 more
doaj   +1 more source

Continuous acceleration of neural activity of the GnRH pulse generator during chronic peripheral infusion of neurokinin 3 receptor agonist in goats

The Journal of Reproduction and Development, 2023
Secretion of pulsatile gonadotropin-releasing hormone (GnRH) is essential for reproduction. Kisspeptin neurons in the arcuate nucleus (ARC), which coexpress neurokinin B (NKB) and its receptor (NK3R), are believed to be components of the GnRH pulse ...
Takashi YAMAMURA, Hiroaki OKAMURA, Yoshihiro WAKABAYASHI   +2 more
doaj   +1 more source

Differential Impact of Subcutaneous Neurokinin B Administration on Epididymal Proliferation in Adult New Zealand White Rabbits: A Dose-Dependent Study

Pakistan Armed Forces Medical Journal
Objective: To investigate the potential of variable doses of Neurokinin B on histomorphology of epididymis in adult rabbits. Study Design: Laboratory-based experimental study.
Faiqah Ramzan, Ramsha Zahra, Muhammad Haris Ramzan   +2 more
doaj   +1 more source

Peripheral administration of SB223412, a selective neurokinin-3 receptor antagonist, suppresses pulsatile luteinizing hormone secretion by acting on the gonadotropin-releasing hormone pulse generator in estrogen-treated ovariectomized female goats

The Journal of Reproduction and Development, 2020
Accumulating evidence suggests that KNDy neurons located in the hypothalamic arcuate nucleus (ARC), which are reported to express kisspeptin, neurokinin B, and dynorphin A, are indispensable for the gonadotropin-releasing hormone (GnRH) pulse generation ...
Takuya SASAKI, Tomoya SONODA, Ryoki TATEBAYASHI, Yuri KITAGAWA, Shinya OISHI, Koki YAMAMOTO, Nobutaka FUJII, Naoko INOUE, Yoshihisa UENOYAMA, Hiroko TSUKAMURA, Kei-ichiro MAEDA, Fuko MATSUDA, Yasuhiro MORITA, Shuichi MATSUYAMA, Satoshi OHKURA   +14 more
doaj   +1 more source

Kisspeptin and neurokinin B neuroendocrine pathways in the control of human ovulation

Journal of neuroendocrinology
The roles of initially kisspeptin and subsequently neurokinin B pathways in the regulation of human reproduction through the control of GnRH secretion were first identified 20 years ago, as essential for the onset of puberty in both boys and girls ...
R. Anderson
semanticscholar   +1 more source

Alteration of Neurokinin B Gene Expression and Hypothalamic-Pituitary- Gonadal Axis in Response to One-month Regular Moderate Physical Activity [PDF]

Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk, 2017
Background: The advantageous effects of the regular moderate physical activity (Exercise) on reproduction is widely accepted, but until now, the alterations of the expression of hypothalamic arcuate nuclei gene affecting on reproduction axis in response ...
Nazli Khajehnasiri, Homayoun Khazali, Farzam Sheikhzadeh Hesari   +2 more
doaj  

Structure–activity relationship study on senktide for development of novel potent neurokinin-3 receptor selective agonists [PDF]

, 2015
Neurokinin B (NKB) regulates the secretion of gonadotropin-releasing hormone (GnRH) in the hypothalamus via activation of the cognate neurokinin-3 receptor (NK3R).
Fujii, Nobutaka, Matsuda, Fuko, Misu, Ryosuke, Noguchi, Taro, Ohkura, Satoshi, Ohno, Hiroaki, Oishi, Shinya, Okamura, Hiroaki, Yamada, Ai, Yamamoto, Koki, Yamamura, Takashi   +10 more
core   +1 more source

Substance P regulates puberty onset and fertility in the female mouse [PDF]

, 2015
Puberty is a tightly regulated process that leads to reproductive capacity. Kiss1 neurons are crucial in this process by stimulating GnRH, yet how Kiss1 neurons are regulated remains unknown. Substance P (SP), an important neuropeptide in pain perception,
Carroll, R.S., Gill, J.C., Kaiser, U.B., Maguire, C.A., Navarro, V.M., Simavli, Serap Aynur, Thompson, I.R., Wolfe, A.   +7 more
core   +1 more source

Kisspeptin and Neurokinin B Signaling Network Underlies the Pubertal Increase in GnRH Release in Female Rhesus Monkeys

Endocrinology, 2017
James P. Garcia, Kathryn A. Guerriero, K. Keen, B. Kenealy, S. Seminara, E. Terasawa   +5 more
semanticscholar   +2 more sources