Myelitis-Predominant Aggressive Phenotype: Unveiling Unique Patterns of Late-Onset Neuromyelitis Optica Spectrum Disorders. [PDF]
Ann NeurolObjective The objective of this study was to compare clinical features and prognosis of late‐onset neuromyelitis optica spectrum disorder (LO‐NMOSD, onset age ≥60 years) with adult‐onset NMOSD (AO‐NMOSD, onset age 18–59 years), and to provide insights for individualized management in elderly patients.
Pu YL +15 more
europepmc +2 more sources
Pathophysiologisch-serologische, bildgebende und klinische Charakteristika der Neuromyelitis Optica [PDF]
, 2019 Hintergrund: Neuromyelitis optica-Spektrum-Erkrankungen (NMOSD) stellen eine Gruppe neuroinflammatorischer Erkrankungen dar, die mit dem klinischen Auftreten von Myelitiden und/oder Optikusneuritiden (ON) einhergeht.
Schumacher, Sophie
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Neuromyelitis Optica with NMO-IgG/ Anti-AQP4 Antibody Positive: First Case Reported from Uttarakhand India [PDF]
Journal of Clinical and Diagnostic Research, 2014 Neuromyelitis optica (also known as Devic’s disease) is an idiopathic, severe, demyelinating disease of the central nervous system that preferentially affects the optic nerve and spinal cord.
Manish Mittal, Garima Mittal
doaj +1 more source
Predictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorders [PDF]
, 2019 The detection of IgG aquaporin-4 antibodies in the serum of patients with Neuromyelitis optica (NMO) has dramatically improved the diagnosis of this disease and its distinction from multiple sclerosis.
Abril-Jaramillo, Javier +14 more
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Neural Regeneration Research, 2019 Variants at the GTF2I repeat domain containing 1 (GTF2IRD1)–GTF2I locus are associated with primary Sjögren’s syndrome, systemic lupus erythematosus, and rheumatoid arthritis.
Jing-Lu Xie +9 more
doaj +1 more source
Rituximab monitoring and redosing in pediatric neuromyelitis optica spectrum disorder. [PDF]
, 2016 OBJECTIVE: To study rituximab in pediatric neuromyelitis optica (NMO)/NMO spectrum disorders (NMOSD) and the relationship between rituximab, B cell repopulation, and relapses in order to improve rituximab monitoring and redosing.
Alper, G +14 more
core +1 more source
Journal of Medical Case Reports, 2019 Background Neuromyelitis optica spectrum disorders are severe autoimmune inflammatory diseases of the central nervous system associated with the presence of immunoglobulin G antibodies against the water channel protein aquaporin-4.
Susanne Bejerot +6 more
doaj +1 more source
Imaging markers of disability in aquaporin-4 immunoglobulin G seropositive neuromyelitis optica: a graph theory study [PDF]
, 2019 Neuromyelitis optica spectrum disorders lack imaging biomarkers associated with disease course and supporting prognosis. This complex and heterogeneous set of disorders affects many regions of the central nervous system, including the spinal cord and ...
Asseyer, Susanna +10 more
core +2 more sources
Neuromyelitis optica spectrum disorder
Brain and nerve = Shinkei kenkyu no shinpo, 2021 Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disorder primarily associated with optic neuritis, myelitis or area postrema syndrome. Several lines of evidence suggest that NMOSD is a humoral immune disease mainly caused by aquaporin-4 antibody and related complement-dependent cytotoxicity against astrocytes.
openaire +3 more sources
Frontiers in Immunology, 2021 BackgroundDemyelination diseases are complex puzzles that are not always straightforward to diagnose. Multiple sclerosis and neuromyelitis optica are two that are frequently encountered.
Ke Shang +7 more
doaj +1 more source