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HDAC1 Regulates Neuronal Differentiation [PDF]

Frontiers in Molecular Neuroscience, 2022
In adult hippocampal neurogenesis, chromatin modification plays an important role in neural stem cell self-renewal and differentiation by regulating the expression of multiple genes. Histone deacetylases (HDACs), which remove acetyl groups from histones,
Vanesa Nieto-Estevez, Vanesa Nieto-Estevez, Gopakumar Changarathil, Gopakumar Changarathil, Adebayo Olukayode Adeyeye, Adebayo Olukayode Adeyeye, Marissa Olga Coppin, Marissa Olga Coppin, Rawan Serena Kassim, Rawan Serena Kassim, Jingfei Zhu, Jenny Hsieh, Jenny Hsieh   +12 more
doaj   +3 more sources

Transferrin Enhances Neuronal Differentiation

ASN Neuro, 2023
Although transferrin (Tf) is a glycoprotein best known for its role in iron delivery, iron-independent functions have also been reported. Here, we assessed apoTf (aTf) treatment effects on Neuro-2a (N2a) cells, a mouse neuroblastoma cell line which, once
María Julia Pérez, Tomas Roberto Carden, Paula Ayelen dos Santos Claro, Susana Silberstein, Pablo Martin Páez, Veronica Teresita Cheli, Jorge Correale, Juana M. Pasquini   +7 more
doaj   +4 more sources

CDK2 inhibition promotes neuronal differentiation in neuroblastoma [PDF]

Scientific Reports
Neuroblastoma (NB) is a childhood tumor arising from neural crest-derived progenitor cells. Cyclin dependent kinase 2 (CDK2) has been suggested to be a promising therapeutic target in NB especially MYCN-amplified tumors.
Mohammad Alzrigat, Loay Mahmoud, Ada Nursel Topçu, Marta Valenti, Lu Zhang, Puck Veen, Fabian John, Wesam Bazzar, Kaisa Lehti, Lars-Gunnar Larsson   +9 more
doaj   +2 more sources

Point-Substitution of Phenylalanine Residues of 26RFa Neuropeptide: A Structure-Activity Relationship Study

Molecules, 2021
26RFa is a neuropeptide that activates the rhodopsin-like G protein-coupled receptor QRFPR/GPR103. This peptidergic system is involved in the regulation of a wide array of physiological processes including feeding behavior and glucose homeostasis. Herein,
Benjamin Lefranc, Karima Alim, Cindy Neveu, Olivier Le Marec, Christophe Dubessy, Jean A. Boutin, Julien Chuquet, David Vaudry, Gaëtan Prévost, Marie Picot, Hubert Vaudry, Nicolas Chartrel, Jérôme Leprince   +12 more
doaj   +1 more source

Intranasal Administration of PACAP Is an Efficient Delivery Route to Reduce Infarct Volume and Promote Functional Recovery After Transient and Permanent Middle Cerebral Artery Occlusion

Frontiers in Endocrinology, 2021
Intranasal (IN) administration appears to be a suitable route for clinical use as it allows direct delivery of bioactive molecules to the central nervous system, reducing systemic exposure and sides effects.
Asma Cherait, Asma Cherait, Asma Cherait, Julie Maucotel, Julie Maucotel, Benjamin Lefranc, Benjamin Lefranc, Jérôme Leprince, Jérôme Leprince, David Vaudry, David Vaudry   +10 more
doaj   +1 more source

Intermittent hypoxia in a mouse model of apnea of prematurity leads to a retardation of cerebellar development and long-term functional deficits

Cell & Bioscience, 2022
Background Apnea of prematurity (AOP) is caused by respiratory control immaturity and affects nearly 50% of premature newborns. This pathology induces perinatal intermittent hypoxia (IH), which leads to neurodevelopmental disorders.
S. Leroux, A. Rodriguez-Duboc, A. Arabo, M. Basille-Dugay, D. Vaudry, D. Burel   +5 more
doaj   +1 more source

Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Protects Striatal Cells and Improves Motor Function in Huntington’s Disease Models: Role of PAC1 Receptor

Frontiers in Pharmacology, 2022
Huntington’s disease (HD) is a hereditary neurodegenerative disorder caused by the expression of mutant huntingtin (mHtt). One of the main features of HD is the degeneration of the striatum that leads to motor discoordination. Pituitary adenylate cyclase-
Irene Solés-Tarrés, Núria Cabezas-Llobet, Benjamin Lefranc, Benjamin Lefranc, Jérôme Leprince, Jérôme Leprince, Jordi Alberch, Jordi Alberch, Jordi Alberch, David Vaudry, David Vaudry, Xavier Xifró   +11 more
doaj   +1 more source

Cell-penetrating, antioxidant SELENOT mimetic protects dopaminergic neurons and ameliorates motor dysfunction in Parkinson's disease animal models

Redox Biology, 2021
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction for which there is an unmet need for better treatment options.
Ifat Alsharif, Loubna Boukhzar, Benjamin Lefranc, David Godefroy, Juliette Aury-Landas, Jean-Luc do Rego, Jean-Claude do Rego, Frédéric Naudet, Arnaud Arabo, Abdeslam Chagraoui, David Maltête, Abdelhamid Benazzouz, Catherine Baugé, Jérôme Leprince, Abdel G. Elkahloun, Lee E. Eiden, Youssef Anouar   +16 more
doaj   +1 more source

miRNA-based rapid differentiation of purified neurons from hPSCs advancestowards quick screening for neuronal disease phenotypes in vitro [PDF]

, 2020
Obtaining differentiated cells with high physiological functions by an efficient, but simple and rapid differentiation method is crucial for modeling neuronal diseases in vitro using human pluripotent stem cells (hPSCs).
Aoyama, Takeshi, Ishikawa, Mitsuru, Miyoshi, Hiroyuki, Morota, Saori, Nakamura, Mari, Okano, Hideyuki, Shibata, Shoichiro, Sone, Takefumi, Uchino, Hiroyuki, Watanabe, Hirotaka, Yoo, Andrew S   +10 more
core   +2 more sources

Dopamine D3 Receptor: Contemporary Views of Its Function and Pharmacology for Neuropsychiatric Diseases

Biomolecules, 2021
Biomolecules has launched a Special Issue entitled “Dopamine D3 Receptor: Contemporary Views of Its Function and Pharmacology for Neuropsychiatric Diseases [...]
Philippe De Deurwaerdère, Abdeslam Chagraoui   +1 more
doaj   +1 more source