Results 11 to 20 of about 2,763,782 (330)

HDAC1 Regulates Neuronal Differentiation

Frontiers in Molecular Neuroscience, 2022
In adult hippocampal neurogenesis, chromatin modification plays an important role in neural stem cell self-renewal and differentiation by regulating the expression of multiple genes. Histone deacetylases (HDACs), which remove acetyl groups from histones,
Vanesa Nieto-Estevez, Vanesa Nieto-Estevez, Gopakumar Changarathil, Gopakumar Changarathil, Adebayo Olukayode Adeyeye, Adebayo Olukayode Adeyeye, Marissa Olga Coppin, Marissa Olga Coppin, Rawan Serena Kassim, Rawan Serena Kassim, Jingfei Zhu, Jenny Hsieh, Jenny Hsieh   +12 more
doaj   +2 more sources

Interleukin-1 beta promotes neuronal differentiation through the Wnt5a/RhoA/JNK pathway in cortical neural precursor cells

Molecular Brain, 2018
Pro-inflammatory cytokine interleukin-1 beta (IL-1β) is a key mediator of inflammation and stress in the central nervous system (CNS), and is highly expressed in the developing brain.
Shin-Young Park, Min-Jeong Kang, Joong-Soo Han   +2 more
doaj   +2 more sources

Extracellular matrix and biomimetic engineering microenvironment for neuronal differentiation

Neural Regeneration Research, 2020
Extracellular matrix (ECM) influences cell differentiation through its structural and biochemical properties. In nervous system, neuronal behavior is influenced by these ECMs structures which are present in a meshwork, fibrous, or tubular forms ...
Deepak Jain, Sabrina Mattiassi, Eyleen L Goh, Evelyn K.F. Yim   +3 more
doaj   +2 more sources

Induction of Neuronal Differentiation of Murine N2a Cells by Two Polyphenols Present in the Mediterranean Diet Mimicking Neurotrophins Activities: Resveratrol and Apigenin

Diseases, 2018
In the prevention of neurodegeneration associated with aging and neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease), neuronal differentiation is of interest.
Amira Namsi, Thomas Nury, Haithem Hamdouni, Aline Yammine, Anne Vejux, Dominique Vervandier-Fasseur, Norbert Latruffe, Olfa Masmoudi-Kouki, Gérard Lizard   +8 more
doaj   +2 more sources

Full UPF3B function is critical for neuronal differentiation of neural stem cells [PDF]

Molecular Brain, 2015
Acknowledgments We thank Fred H Gage (Salk Institute, La Jolla, CA, USA) for HCN-A94 cells and Niels Gehring (University of Cologne, Germany) for constructs.
Alrahbeni, Tahani, Anderson, Jihan, McCaig, Colin, Miedzybrodzka, Zosia, Muller, Berndt, Sartor, Francesca   +5 more
core   +3 more sources

Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs [PDF]

Nature Communications, 2020
Human induced pluripotent stem cells (hiPSCs) are a powerful model of neural differentiation and maturation. We present a hiPSC transcriptomics resource on corticogenesis from 5 iPSC donor and 13 subclonal lines across 9 time points over 5 broad ...
Emily E. Burke, Joshua G. Chenoweth, Joo Heon Shin, Leonardo Collado‐Torres, Suel–Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R. Hamersky, Marcelo Diaz Bustamante, BaDoi N. Phan, William S. Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J. Price, Anandita Rajpurohit, Stephen A. Semick, Roland W. Bürli, James C. Barrow, Daniel J. Hiler, Stephanie C. Page, Keri Martinowich, Thomas M. Hyde, Joel E. Kleinman, Karen F. Berman, José Apud, A.J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Brady J. Maher, Ronald D.G. McKay, Andrew E. Jaffe   +36 more
openalex   +2 more sources

FOXP2 drives neuronal differentiation by interacting with retinoic acid signaling pathways

Frontiers in Cellular Neuroscience, 2014
FOXP2 was the first gene shown to cause a Mendelian form of speech and language disorder. Although developmentally expressed in many organs, loss of a single copy of FOXP2 leads to a phenotype that is largely restricted to orofacial impairment during ...
Paolo eDevanna, Jeroen eMiddelbeek, Sonja Catherine Vernes, Sonja Catherine Vernes   +3 more
doaj   +2 more sources

Carbon Nanotube–Hydrogel Composites Facilitate Neuronal Differentiation While Maintaining Homeostasis of Network Activity

Advances in Materials, 2021
It is often assumed that carbon nanotubes (CNTs) stimulate neuronal differentiation by transferring electrical signals and enhancing neuronal excitability.
Lijun Ye, Haichao Ji, Jie Liu, C. Tu, M. Kappl, K. Koynov, J. Vogt, H. Butt   +7 more
semanticscholar   +1 more source

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation

Frontiers in Pharmacology, 2020
Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
semanticscholar   +1 more source

Metabolic reprogramming during neuronal differentiation from aerobic glycolysis to neuronal oxidative phosphorylation

eLife, 2016
How metabolism is reprogrammed during neuronal differentiation is unknown. We found that the loss of hexokinase (HK2) and lactate dehydrogenase (LDHA) expression, together with a switch in pyruvate kinase gene splicing from PKM2 to PKM1, marks the ...
Xinde Zheng, Leah Boyer, Mingji Jin, Jérôme Mertens, Yongsung Kim, Li Ma, Li Ma, Michael Hamm, Fred H. Gage, Tony Hunter   +9 more
openalex   +2 more sources