Results 1 to 10 of about 184,124 (288)
Cathepsins in neuronal plasticity.
Neural Regen Res, 2021 Proteases comprise a variety of enzymes defined by their ability to catalytically hydrolyze the peptide bonds of other proteins, resulting in protein lysis. Cathepsins, specifically, encompass a class of at least twenty proteases with potent endopeptidase activity.
Tran AP, Silver J.
europepmc +5 more sources
The Histone Modifications of Neuronal Plasticity. [PDF]
Neural Plast, 2021 Nucleosomes composed of histone octamer and DNA are the basic structural unit in the eukaryote chromosome. Under the stimulation of various factors, histones will undergo posttranslational modifications such as methylation, phosphorylation, acetylation, and ubiquitination, which change the three-dimensional structure of chromosomes and affect gene ...
Geng H, Chen H, Wang H, Wang L.
europepmc +5 more sources
Neuronal Plasticity in the Entorhinal Cortex
Neural Plasticity, 2008 The entorhinal cortex (EC) is a unique and fascinating structure, constituting a highly parallel interface between phylogenetically old cortex (hippocampus) and higher neocortical areas. The literature related to the EC has increased dramatically in the past 30 years. A simple PubMed search for EC lists around 20–40 articles per year in the early 1980s.
C. Andrew Chapman +2 more
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S‐nitrosation and neuronal plasticity [PDF]
British Journal of Pharmacology, 2014 Nitric oxide (NO) has long been recognized as a multifaceted participant in brain physiology. Despite the knowledge that was gathered over many years regarding the contribution of NO to neuronal plasticity, for example the ability of the brain to change in response to new stimuli, only in recent years have we begun to understand how NO acts on the ...
Inês M. Araújo +3 more
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Autophagy in Neuronal Development and Plasticity [PDF]
Trends in Neurosciences, 2020 Autophagy is a highly conserved intracellular clearance pathway in which cytoplasmic contents are trafficked to the lysosome for degradation. Within neurons, it helps to remove damaged organelles and misfolded or aggregated proteins and has therefore been the subject of intense research in relation to neurodegenerative disease.
Fleming, Angeleen, Rubinsztein, David C
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Vascular endothelial‐cadherin as a marker of endothelial injury in preclinical Alzheimer disease
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1926-1940, December 2022., 2022 Abstract Objective Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial‐cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.
Rawan Tarawneh +5 more
wiley +1 more source
A transient inflammatory response contributes to oxaliplatin neurotoxicity in mice
Annals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1985-1998, December 2022., 2022 Abstract Objectives Peripheral neuropathy is a relevant dose‐limiting adverse event that can affect up to 90% of oncologic patients with colorectal cancer receiving oxaliplatin treatment. The severity of neurotoxicity often leads to dose reduction or even premature cessation of chemotherapy.
Aina Calls +9 more
wiley +1 more source
Plastic neural network with transmission delays promotes equivalence between function and structure [PDF]
, 2022 The brain is formed by cortical regions that are associated with different cognitive functions. Neurons within the same region are more likely to connect than neurons in distinct regions, making the brain network to have characteristics of a network of subnetworks.
arxiv +1 more source
Plasticity of intrinsic neuronal excitability [PDF]
Current Opinion in Neurobiology, 2019 Long-term synaptic modification is not the exclusive mode of memory storage, and persistent regulation of voltage-gated ion channels also participates in memory formation. Intrinsic plasticity is expressed in virtually all neuronal types including principal cells and interneurons.
Debanne, Dominique +2 more
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Error correction and fast detectors implemented by ultra-fast neuronal plasticity [PDF]
Phys. Rev. E 89, 042712 (2014), 2014 We experimentally show that the neuron functions as a precise time-integrator, where the accumulated changes in neuronal response latencies, under complex and random stimulation patterns, are solely a function of a global quantity, the average time-lag between stimulations.
arxiv +1 more source