Olfactory bulb plasticity ensures proper olfaction after severe impairment in postnatal neurogenesis
Scientific Reports, 2017 The olfactory bulb (OB) neurons establish a complex network that ensures the correct processing of the olfactory inputs. Moreover, the OB presents a lifelong addition of new neurons into its existing circuitry.
D. Díaz +5 more
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The Autism Related Protein Contactin-Associated Protein-Like 2 (CNTNAP2) Stabilizes New Spines: An In Vivo Mouse Study. [PDF]
, 2015 The establishment and maintenance of neuronal circuits depends on tight regulation of synaptic contacts. We hypothesized that CNTNAP2, a protein associated with autism, would play a key role in this process.
Gdalyahu, Amos +5 more
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Syncrip/hnRNP Q is required for activity-induced Msp300/Nesprin-1 expression and new synapse formation. [PDF]
, 2019 Memory and learning involve activity-driven expression of proteins and cytoskeletal reorganization at new synapses, requiring posttranscriptional regulation of localized mRNA a long distance from corresponding nuclei.
Davis, Ilan +6 more
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Reduced neurosteroid potentiation of GABAA receptors in epilepsy and depolarized hippocampal neurons [PDF]
, 2020 OBJECTIVE: Neurosteroids regulate neuronal excitability by potentiating γ-aminobutyric acid type-A receptors (GABARs). In animal models of temporal lobe epilepsy, the neurosteroid sensitivity of GABARs is diminished and GABAR subunit composition is ...
Jansen, Laura A +3 more
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Birdsongs alleviate anxiety and paranoia in healthy participants
Scientific Reports, 2022 The present study investigated the effect of urban (traffic noise) vs. natural (birdsongs) soundscapes on mood, state paranoia, and cognitive performance, hypothesizing that birdsongs lead to significant improvements in these outcomes. An additional goal
E. Stobbe +3 more
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Alterations in brain connectivity due to plasticity and synaptic delay
, 2017 Brain plasticity refers to brain's ability to change neuronal connections, as a result of environmental stimuli, new experiences, or damage. In this work, we study the effects of the synaptic delay on both the coupling strengths and synchronisation in a ...
Batista, A. M. +8 more
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Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]
, 2010 Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P. +9 more
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Frontiers in Molecular Neuroscience, 2017 Synaptic cell adhesion molecules represent important targets for neuronal activity-dependent proteolysis. Postsynaptic neuroligins (NLs) form trans-synaptic complexes with presynaptic neurexins (NXs). Both NXs and NLs are cleaved from the cell surface by
Michelle D. Gjørlund +9 more
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Critical neural networks with short and long term plasticity
, 2017 In recent years self organised critical neuronal models have provided insights regarding the origin of the experimentally observed avalanching behaviour of neuronal systems.
de Arcangelis, L. +3 more
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Calcium in the initiation, progression and as an effector of Alzheimer's disease pathology. [PDF]
, 2009 The cause(s) of sporadic Alzheimer's disease (sAD) are complex and currently poorly understood. They likely result from a combination of genetic, environmental, proteomic and lipidomic factors that crucially occur only in the aged brain.
Green, Kim N
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