Results 41 to 50 of about 177,448 (197)

Impaired synaptic incorporation of AMPA receptors in a mouse model of fragile X syndrome

Frontiers in Molecular Neuroscience, 2023
Fragile X syndrome (FXS) is the most common monogenetic cause of inherited intellectual disability and autism in humans. One of the well-characterized molecular phenotypes of Fmr1 KO mice, a model of FXS, is increased translation of synaptic proteins ...
Magdalena Chojnacka, Anna Beroun, Marta Magnowska, Aleksandra Stawikowska, Dominik Cysewski, Jacek Milek, Magdalena Dziembowska, Bozena Kuzniewska   +7 more
doaj   +1 more source

Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels

Neural Plasticity, 2021
Hippocampal cell death and cognitive dysfunction are common following global cerebral ischemia across all ages, including children. Most research has focused on preventing neuronal death.
Robert M. Dietz, James E. Orfila, Nicholas Chalmers, Crystal Minjarez, Jose Vigil, Guying Deng, Nidia Quillinan, Paco S. Herson   +7 more
doaj   +1 more source

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

eLife, 2017
The amyloid precursor protein (APP) harbors physiological roles at synapses and is central to Alzheimer’s disease (AD) pathogenesis. Evidence suggests that APP intracellular domain (AICD) could regulate synapse function, but the underlying molecular ...
Paula A Pousinha, Xavier Mouska, Elisabeth F Raymond, Carole Gwizdek, Gihen Dhib, Gwenola Poupon, Laure-Emmanuelle Zaragosi, Camilla Giudici, Ingrid Bethus, Emilie Pacary, Michael Willem, Hélène Marie   +11 more
doaj   +1 more source

Astrocyte and Neuronal Plasticity in the Somatosensory System [PDF]

Neural Plasticity, 2015
Changing the whisker complement on a rodent’s snout can lead to two forms of experience-dependent plasticity (EDP) in the neurons of the barrel cortex, where whiskers are somatotopically represented. One form, termed coding plasticity, concerns changes in synaptic transmission and connectivity between neurons.
Sims, Robert, Butcher, John B, Parri, H Rheinallt, Glazewski, Stanislaw   +3 more
openaire   +5 more sources

Cell Type-specific Metabolic Labeling of Proteins with Azidonorleucine in Drosophila

Bio-Protocol, 2017
Advanced mass spectrometry technology has pushed proteomic analyses to the forefront of biological and biomedical research. Limitations of proteomic approaches now often remain with sample preparations rather than with the sensitivity of protein ...
Ines Erdmann, Kathrin Marter, Oliver Kobler, Sven Niehues, Julia Bussmann, Anke Müller, Julia Abele, Erik Storkebaum, Ulrich Thomas, Daniela Dieterich   +9 more
doaj   +1 more source

Strategies for the Identification of Bioactive Neuropeptides in Vertebrates

Frontiers in Neuroscience, 2019
Neuropeptides exert essential functions in animal physiology by controlling e.g., reproduction, development, growth, energy homeostasis, cardiovascular activity and stress response.
Auriane Corbière, Hubert Vaudry, Hubert Vaudry, Philippe Chan, Marie-Laure Walet-Balieu, Thierry Lecroq, Arnaud Lefebvre, Charles Pineau, David Vaudry, David Vaudry, David Vaudry   +10 more
doaj   +1 more source

The Cannabinoid CB1 Antagonist TM38837 With Limited Penetrance to the Brain Shows Reduced Fear-Promoting Effects in Mice

Frontiers in Pharmacology, 2019
Rimonabant was the first selective CB1 antagonist/inverse agonist introduced into clinical practice to treat obesity and metabolic-related disorders. It was withdrawn from market due to the notably increased rates of psychiatric side effects.
Vincenzo Micale, Vincenzo Micale, Vincenzo Micale, Filippo Drago, Pia K. Noerregaard, Christian E. Elling, Carsten T. Wotjak   +6 more
doaj   +1 more source

SYNAPTIC IMBALANCE AND THE NITRIC OXIDE PATHWAY IN THE VPA MOUSE MODEL OF AUTISM

IBRO Neuroscience Reports, 2023
Valeria Lorena Cabedo Navarro, David Pérez-Boyero, Laura Pérez-Revuelta, Eduardo Weruaga Prieto, David Díaz López, José Ramón Alonso Peña   +5 more
doaj   +1 more source

CELL FUSION EVENTS IN THE CEREBELLUM OF A MULTIPLE SCLEROSIS MOUSE MODEL

IBRO Neuroscience Reports, 2023
Pablo González Téllez De Meneses, Valeria Lorena Cabedo Navarro, David Díaz López, José Ramón Alonso Peña, Jorge Valero, Eduardo Weruaga Prieto   +5 more
doaj   +1 more source

Differential inhibition onto developing and mature granule cells generates high-frequency filters with variable gain

eLife, 2015
Adult hippocampal neurogenesis provides the dentate gyrus with heterogeneous populations of granule cells (GC) originated at different times. The contribution of these cells to information encoding is under current investigation.
María Belén Pardi, Mora Belén Ogando, Alejandro F Schinder, Antonia Marin-Burgin   +3 more
doaj   +1 more source