Neuropeptide Y receptors: How to get subtype selectivity [PDF]
Frontiers in Endocrinology, 2013 The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia +2 more
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New antagonist agents of neuropeptide y receptors [PDF]
Química Nova, 2000 In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity.
Ignacio Aldana +8 more
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Neuropeptide Y receptors: a promising target for cancer imaging and therapy. [PDF]
Regen Biomater, 2015 Neuropeptide Y (NPY) was first identified from porcine brain in 1982, and plays its biological functions in humans through NPY receptors (Y1, Y2, Y4 and Y5).
Li J, Tian Y, Wu A.
europepmc +2 more sources
Neuropeptide Y receptor in the rat brain [PDF]
European Journal of Biochemistry, 1984 The specific binding of the chloramine-T iodinated neuropeptide Y (125I-NPY) to membranes from rat cerebral cortex was investigated using equilibrium binding and kinetic methods. The equilibrium binding of 125I-NPY at 37 degrees C was characterized by a Kd value of 0.38 nM. The receptor densities in the cerebral cortex, hypothalamus and cerebellum were
Anders Undén +3 more
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A Promising Therapeutic Target for Metabolic Diseases: Neuropeptide Y Receptors in Humans
Cellular Physiology and Biochemistry, 2017 Human neuropeptide Y (hNPY) is one of the most widely expressed neurotransmitters in the human central and peripheral nervous systems. It consists of 36 highly conserved amino acid residues, and was first isolated from the porcine hypothalamus in 1982 ...
Min Yi +6 more
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Characterization of vascular neuropeptide Y receptors [PDF]
British Journal of Pharmacology, 1992 In the present study we compared neuropeptide Y (NPY) and NPY‐related analogues for their ability to activate or bind to vascular NPY receptors in four experimental set‐ups. Previous results have suggested the existence of different receptor subtypes, Y1 receptors requiring full‐length NPY (1–36) or [Pro34]‐NPY, and Y2 receptors recognizing also N ...
L. Grundemar +5 more
semanticscholar +4 more sources
Targeting Neuropeptide Receptors for Cancer Imaging and Therapy: Perspectives with Bombesin, Neurotensin, and Neuropeptide-Y Receptors [PDF]
Journal of Nuclear Medicine, 2014 Receptors for some regulatory peptides are highly expressed in tumors. Selective radiolabeled peptides can bind with high affinity and specificity to these receptors and exhibit favorable pharmacologic and pharmacokinetic properties, making them suitable agents for imaging or targeted therapy.
C. Morgat +5 more
semanticscholar +4 more sources
Heterobivalent Dual-Target Peptide for Integrin-αvβ3 and Neuropeptide Y Receptors on Breast Tumor [PDF]
PharmaceuticalsBackground/Objectives: Heterodimer peptides targeting more than one receptor can be advantageous, as tumors can simultaneously express more than one receptor type.
Aryel H. Ferreira +2 more
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Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions [PDF]
ASN Neuro, 2015 Neuropeptide Y (NPY) is expressed in mammalian retina but the location and potential modulatory effects of NPY receptor activation remain largely unknown.
João Martins +12 more
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Neuropeptides as regulators of bone metabolism: from molecular mechanisms to traditional Chinese medicine intervention strategies [PDF]
Frontiers in PharmacologyOsteoporosis (OP) is a complex bone metabolism disorder disease that affects the skeleton, nervous system, muscles, and multiple tissues. Neuropeptides, which are endogenous substances derived from both bone and brain, play a critical role in maintaining
Qing Lin +16 more
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