Results 1 to 10 of about 75,376 (234)

Neuropeptide Y receptors: How to get subtype selectivity [PDF]

Frontiers in Endocrinology, 2013
The neuropeptide Y system is a multireceptor/multiligand system consisting of four receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate these receptors with different potency.
Xavier ePedragosa Badia, Jan eStichel, Annette G Beck-Sickinger   +2 more
doaj   +5 more sources

Structural basis of neuropeptide Y signaling through Y1 receptor [PDF]

Nature Communications, 2022
The human neuropeptide Y (NPY) acts through G-protein coupled receptors and is involved in food intake, stress response, anxiety, and memory retention.
Chaehee Park, Jinuk Kim, Seung-Bum Ko, Yeol Kyo Choi, Hyeongseop Jeong, Hyeonuk Woo, Hyunook Kang, Injin Bang, Sang Ah Kim, Tae-Young Yoon, Chaok Seok, Wonpil Im, Hee-Jung Choi   +12 more
doaj   +2 more sources

New antagonist agents of neuropeptide y receptors [PDF]

Química Nova, 2000
In the CNS, NPY has been implicated in obesity and feeding, endocrine function and metabolism. Potent and selective rNPY antagonists will be able to probe the merits of this approach for the treatment of obesity.
Ignacio Aldana, Isabel Rivero, Argimiro Rivero, Patricio Huenchuñir, Carmen Frigola, Maria Luisa Alonso, Antonio Monge, D. H. Caignard, P. Renard   +8 more
doaj   +5 more sources

Empowering exhausted T cells of Glioblastoma patients by Neurotransmitters and Neuropeptides: decreasing immune checkpoint inhibitors, and increasing CD3zeta, proliferation and Glioblastoma arrest [PDF]

Cancer Immunology, Immunotherapy
Background Glioblastoma is the most common malignant brain tumor, with extremely poor prognosis, and patient’s T cells are exhausted, dysfunctional, and unable to eliminate Glioblastoma.
Mia Levite, Nili Ilouz, Eithan Galun, Yigal Shoshan   +3 more
doaj   +2 more sources

Heterobivalent Dual-Target Peptide for Integrin-α_vβ₃ and Neuropeptide Y Receptors on Breast Tumor [PDF]

Pharmaceuticals
Background/Objectives: Heterodimer peptides targeting more than one receptor can be advantageous, as tumors can simultaneously express more than one receptor type.
Aryel H. Ferreira, Caroline C. Real, Osvaldo Malafaia   +2 more
doaj   +2 more sources

Functional deletion of neuropeptide Y receptors type 2 in local synaptic networks of anteroventral BNST facilitates recall and increases return of fear. [PDF]

Mol Psychiatry, 2021
Bartsch JC, Jamil S, Remmes J, Verma D, Pape HC.   +4 more
europepmc   +3 more sources

Ligands of the neuropeptide Y Y2 receptor [PDF]

Bioorganic & Medicinal Chemistry Letters, 2013
Neuropeptide Y (NPY) is one of the most abundant neuropeptides in the mammalian brain and exerts a variety of physiological processes in humans via four different receptor subtypes Y1, Y2, Y4 and Y5. Y2 receptor is the most abundant Y subtype receptor in the central nervous system and implicated with food intake, bone formation, affective disorders ...
Gopi Kumar Mittapalli, Edward Roberts
openalex   +4 more sources

Activation of Neuropeptide Y Receptors Modulates Retinal Ganglion Cell Physiology and Exerts Neuroprotective Actions [PDF]

ASN Neuro, 2015
Neuropeptide Y (NPY) is expressed in mammalian retina but the location and potential modulatory effects of NPY receptor activation remain largely unknown.
João Martins, Filipe Elvas, Dan Brudzewsky, Tânia Martins, Bogdan Kolomiets, Pedro Tralhão, Casper R. Gøtzsche, Cláudia Cavadas, Miguel Castelo-Branco, David P. D. Woldbye, Serge Picaud, Ana R. Santiago, António F. Ambrósio   +12 more
doaj   +2 more sources

Unusually persistent Gαi-signaling of the neuropeptide Y2 receptor depletes cellular Gi/o pools and leads to a Gi-refractory state

Cell Communication and Signaling, 2020
Background A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and internalization into ...
Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl, Annette G. Beck-Sickinger   +4 more
doaj   +1 more source

PET Imaging of the Neuropeptide Y System: A Systematic Review

Molecules, 2022
Neuropeptide Y (NPY) is a vastly studied biological peptide with numerous physiological functions that activate the NPY receptor family (Y1, Y2, Y4 and Y5).
Inês C. F. Fonseca, Miguel Castelo-Branco, Cláudia Cavadas, Antero J. Abrunhosa   +3 more
doaj   +1 more source