Results 101 to 110 of about 17,667,571 (207)

From Theory to Practice: Which Biomarkers Are Ready for Predicting Response in Advanced HCC?

Liver International, Volume 46, Issue 6, June 2026.
ABSTRACT Systemic therapies for advanced hepatocellular carcinoma (HCC) have expanded considerably with the advent of tyrosine kinase inhibitors, immune checkpoint inhibitors and immunotherapy–anti‐angiogenic combinations. However, despite this therapeutic diversification, first‐line treatment selection remains largely empirical, as few biomarkers are ...
Marie Decraecker, Jean‐Frédéric Blanc, Samuel Amintas, Grégoire Manaud   +3 more
wiley   +1 more source

Enhancement of Circulating and Intestinal T Regulatory Cells and Their Expression of Helios and Neuropilin-1 in Children with Inflammatory Bowel Disease

Journal of Inflammation Research, 2020
Katarzyna Sznurkowska,1 Justyna Luty,2 Ewa Bryl,2 Jacek M Witkowski,3 Blanka Hermann-Okoniewska,4 Piotr Landowski,1 Marta Kosek,1 Agnieszka Szlagatys-Sidorkiewicz1 1Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical ...
Sznurkowska K, Luty J, Bryl E, Witkowski JM, Hermann-Okoniewska B, Landowski P, Kosek M, Szlagatys-Sidorkiewicz A   +7 more
doaj  

Floor plate-derived neuropilin-2 functions as a secreted semaphorin sink to facilitate commissural axon midline crossing

, 2015
Commissural axon guidance depends on a myriad of cues expressed by intermediate targets. Secreted semaphorins signal through neuropilin-2/plexin-A1 receptor complexes on post-crossing commissural axons to mediate floor plate repulsion in the mouse spinal
Tessier-Lavigne, Marc, Yoshida, Yutaka, Wu, Zhuhao, Tran, Tracy, Olsen, Olav, Maness, Patricia, Hernandez-Enriquez, Berenice, Kaprielian, Zaven, Martinez, Edward   +8 more
core   +1 more source

Cellular toxicity following application of adeno-associated viral vector-mediated RNA interference in the nervous system

BMC Neuroscience, 2010
Background After a spinal cord lesion, axon regeneration is inhibited by the presence of a diversity of inhibitory molecules in the lesion environment. At and around the lesion site myelin-associated inhibitors, chondroitin sulfate proteoglycans (CSPGs ...
Verhaagen Joost, Niclou Simone P, Eggers Ruben, Ehlert Erich M   +3 more
doaj   +1 more source

The impact of immunohistochemical staining with ezrin-carbonic anhydrase IX and neuropilin-2 on prognosis in patients with metastatic renal cell cancer receiving tyrosine kinase inhibitors

, 2015
The identification of prognostic factors in patients with renal cell carcinoma (RCC) represents an area of increasing interest. In this retrospective study, we evaluated the prognostic role of carbonic anhydrase-IX, ezrin, and neuropilin in metastatic ...
Gonu, Ipek Isik, Turan, Nedim, Afsar, Bans, Gumusay, Ozge, Coskun, Ugur, Cetin, Bulent, Algm, Efnan, Ozet, Ahmet, Buyukberber, Suleyman, Benekli, Mustafa   +9 more
core   +1 more source

Basic implications on three pathways associated with SARS-CoV-2

Biomedical Journal
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) interacts between the host and virus and govern induction, resulting in multiorgan impacts.
Jong hoon Lee, Consolato Sergi, Richard E. Kast, Badar A. Kanwar, Jean Bourbeau, Sangsuk Oh, Mun-Gi Sohn, Chul Joong Lee, Michael D. Coleman   +8 more
doaj   +1 more source

GLI1 regulates a novel neuropilin‐2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation

EMBO Molecular Medicine, 2013
The characterization of cells with tumour initiating potential is significant for advancing our understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers (TNBCs) are enriched for tumour‐initiating cells (TICs).
Hira Lal Goel, Bryan Pursell, Cheng Chang, Leslie M. Shaw, Junhao Mao, Karl Simin, Prashant Kumar, Craig W. Vander Kooi, Leonard D. Shultz, Dale L. Greiner, Jens Henrik Norum, Rune Toftgard, Charlotte Kuperwasser, Arthur M. Mercurio   +13 more
doaj   +1 more source

Abstract 3950: Neuropilin-2, a transmembrane glycoprotein receptor, protects prostate cancer cells from stress

, 2010
Prostate cancer is the most common cancer and the second leading cause of cancer death in men in the United States. Definitive treatment consists of either radical prostatectomy or radiotherapy followed by androgen deprivation.
Kaustubh Datta, Donald J. Tindall, Enfeng Wang, Heyu Zhang   +3 more
core   +1 more source

Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non–small cell lung cancer

, 2020
OBJECTIVE: Innate and acquired resistance is the principle factor limiting the efficacy of tyrosine kinase inhibitors in lung cancer. We have observed a dramatic upregulation of the cell surface co-receptor neuropilin-2b in lung cancers clinically ...
Kent E. Armeson, Cecile Nasarre, Yuri K. Peterson, Nasarre, Patrick, Gooz, Monika, Monika Gooz, Drabkin, Harry A., Barry C. Gibney, Chadrick E. Denlinger, Peterson, Yuri K., Harry A. Drabkin, Robert M. Gemmill, Patrick Nasarre, Nasarre, Cecile, Armeson, Kent E., Anastasios Dimou, Gibney, Barry C., Gemmill, Robert M., Pagano, Rose, Denlinger, Chadrick E., Rose Pagano, Dimou, Anastasios   +21 more
core   +1 more source

Prognostic value and in vitro biological relevance of Neuropilin 1 and Neuropilin 2 in osteosarcoma [PDF]

, 2015
Neoadjuvant chemotherapy in osteosarcoma increased the long-term survival of patients with localized disease considerably but metastasizing osteosarcoma remained largely treatment resistant.
Born, Walter, Bertz, Josefine, Lengnick, Harald, Boro, Aleksandar, Robl, Bernhard, Fuchs, Bruno, Husmann, Maren, Arlt, Matthias Je   +7 more
core   +1 more source