Results 81 to 90 of about 17,667,571 (207)
The role of neuropilin 2 in physiological and pathological angiogenesis and lymphangiogenesis [PDF]
, 2016 The generation of new lymphatic vessels through lymphangiogenesis has been implicated in many disease states. This process has some overlap with the better studied angiogenesis pathway, but is under distinct molecular control.
Mucka, Patrick
core
, 1998 Neuropilins bind secreted members of the semaphorin family of proteins. Neuropilin-1 is a receptor for Sema III. Here, we show that neuropilin-2 is a receptor for the secreted semaphorin Sema IV and acts selectively to mediate repulsive guidance events ...
Ginty, David D +5 more
core +1 more source
Nature Communications, 2017 Neuropilin 2 (Nrp2) is expressed by a subset of mitral cells in the postero-ventral olfactory bulb in mice. Here the authors show that Nrp2 is sufficient to instruct mitral cell targeting to the anterior part of medial amygdala that modulates olfactory ...
Kasumi Inokuchi +8 more
doaj +1 more source
Semaphorin 3F and neuropilin-2 control the migration of human T-cell precursors. [PDF]
PLoS ONE, 2014 Neuropilins and semaphorins are known as modulators of axon guidance, angiogenesis, and organogenesis in the developing nervous system, but have been recently evidenced as also playing a role in the immune system. Here we describe the expression and role
Daniella Arêas Mendes-da-Cruz +20 more
doaj +1 more source
A noncanonical role for Jagged1 in endothelial mechanotransduction
The FEBS Journal, EarlyView.This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez +7 more
wiley +1 more source
, 2016 Comparison of neuropilin-1 (NRP-1) and neuropilin-2 (NRP-2) expression in alveolar macrophages and interstitial macrophages in lung tissue remote to the cancer nest (physiologically normal lung) (n = 5).
Hongxue Meng (2272915) +6 more
core +1 more source
VEGF family members : modulators of tumor angiogenesis and lymphangiogenesis [PDF]
, 2006 Members of the vascular endothelial growth factor (VEGF) family and their receptors (VEGFR) play an essential role in the development and maintenance of the blood and lymphatic vasculature.
Kopfstein, Lucie
core +1 more source
ADAM17 and its proteolytic targets in disease pathogenesis
The FEBS Journal, EarlyView.ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley +1 more source
Expression of placental growth factor, neuropilin-1, and neuropilin-2 in primary pterygium tissue
, 2023 Purpose The aim of this study was to evaluate the expression of placental growth factor (PLGF), neuropilin-1 (NP-1), and neuropilin-2 (NP-2) molecules in primary pterygium tissue compared with normal conjunctival tissue.Methods The records of 42 patients
Oltulu, Refik +3 more
core +1 more source
Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide. [PDF]
Am J Physiol Lung Cell Mol Physiol, 2018 Neuropilins are multifunctional receptors that play important roles in immune regulation. Neuropilin-2 (NRP2) is expressed in the lungs, but whether it regulates airway immune responses is unknown. Here, we report that Nrp2 is weakly expressed by alveolar macrophages (AMs) in the steady state but is dramatically upregulated following in vivo ...
Immormino RM +10 more
europepmc +3 more sources