Results 1 to 10 of about 76,968 (134)

Neuroprotection [PDF]

British Medical Bulletin, 2000
Thrombolysis improves stroke outcome, but is applicable to a limited number of patients. Neuroprotection has the prospect to be universally offered, either alone or in combination with thrombolysis. Potential drug targets include elements of the excitotoxic glutamate cascade, calcium entry, intracellular protease activation, free radical damage, the ...
Kennedy R. Lees
openalex   +3 more sources

Neuroprotection by estradiol [PDF]

Progress in Neurobiology, 2001
This review highlights recent evidence from clinical and basic science studies supporting a role for estrogen in neuroprotection. Accumulated clinical evidence suggests that estrogen exposure decreases the risk and delays the onset and progression of Alzheimer's disease and schizophrenia, and may also enhance recovery from traumatic neurological injury
Luis Miguel García‐Segura, Íñigo Azcoitia, Lydia L. DonCarlos   +2 more
openalex   +4 more sources

Hibernation, a Model of Neuroprotection [PDF]

TheScientificWorldJOURNAL, 2001
Hibernation, a natural model of tolerance to cerebral ischemia, represents a state of pronounced fluctuation in cerebral blood flow where no brain damage occurs. Numerous neuroprotective aspects may contribute in concert to such tolerance. The purpose of this study was to determine whether hibernating brain tissue is tolerant to penetrating brain ...
Fang Zhou, Mark A. Smith, Rudy J. Castellani, Raphaela Stimmelmayr, George Perry, Kelly L. Drew, Xiongwei Zhu   +6 more
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Mitophagy and Neuroprotection [PDF]

Trends in Molecular Medicine, 2020
Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms.
Konstantinos Palikaras, Guofeng Lou, Nektarios Tavernarakis, Nektarios Tavernarakis, Evandro Fei Fang, Morten Scheibye-Knudsen, Sofie Lautrup   +6 more
openaire   +5 more sources

Neuroprotection by flavonoids [PDF]

Brazilian Journal of Medical and Biological Research, 2003
The high morbidity, high socioeconomic costs and lack of specific treatments are key factors that define the relevance of brain pathology for human health and the importance of research on neuronal protective agents. Epidemiological studies have shown beneficial effects of flavonoids on arteriosclerosis-related pathology in general and ...
Dajas, F., Rivera-Megret, F., Blasina, F., Arredondo, F., Abin-Carriquiry, J.A., Costa, G., Echeverry, C., Lafon, L., Heizen, H., Ferreira, M., Morquio, A.   +10 more
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Hypothermic neuroprotection [PDF]

Neurotherapeutics, 2006
The possibility that hypothermia during or after resuscitation from asphyxia at birth, or cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very long time. It is now known that severe hypoxia-ischemia may not necessarily cause immediate cell death, but can precipitate a complex biochemical cascade leading to the ...
Gunn, AJ, Thoresen, M
openaire   +3 more sources

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]

, 2010
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon, AD Mosnaim, Amelia G Johnson, B Reisberg, B Zhang, CA Dickey, CA Dickey, Chad A Dickey, Clara Kraft, Edwin J Weeber, EM Sigurdsson, Erin E Congdon, F van Bebber, HM Hassan, I Walter-Sack, J Lewis, Jason E Gestwicki, Jeffrey R Jones, John C O'Leary, John Koren, Jose F Abisambra, K Santacruz, Karen E Duff, Laura J Blair, M Necula, M Oz, Melinda Peters, MJ West, ML Smith, MP Mazanetz, Paul Marinec, Qingyou Li, RS Doody, S Deiana, S Taniguchi, TL Spires-Jones, TM Visarius, UK Jinwal, Umesh K Jinwal   +38 more
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The future of ischemic stroke: flow from prehospital neuroprotection to definitive reperfusion. [PDF]

, 2014
Recent advances in ischemic stroke enable a seamless transition of the patient flow from the prehospital setting to definitive reperfusion, without the arbitrary separation of therapeutic phases of ischemia based on time alone.
Ip, Hing Lung, Liebeskind, David S
core   +1 more source

Argon protects against hypoxic-ischemic brain injury in neonatal rats through activation of Nuclear factor (erythroid-derived 2)-like 2 [PDF]

, 2016
Perinatal hypoxic ischaemic encephalopathy (HIE) has a high mortality rate with neuropsychological impairment. This study investigated the neuroprotective effects of argon against neonatal hypoxic-ischaemic brain injury.
Ciechanowicz, S, Ji, X, Ma, D, Mitchell, S, Savage, S, Wang, T, Zhao, H   +6 more
core   +1 more source

Neuroprotective efficacy of nimesulide against hippocampal neuronal damage following transient forebrain ischemia [PDF]

, 2002
Cyclooxygenase-2 is involved in the inflammatory component of the ischemic cascade, playing an important role in the delayed progression of the brain damage.
Alvarez, Dalia, Candelario-Jalil, Eduardo, Garcia-Cabrera, Michel, Giuliani, Attilia, Gonzalez-Falcon, Armando, Leon, Olga S., Martinez-Sanchez, Gregorio, Merino, Nelson   +7 more
core   +1 more source