Results 1 to 10 of about 172,128 (178)
Pharmaceuticals, 2022 Nogo-A protein is a key myelin-associated inhibitor of axonal growth, regeneration, and plasticity in the central nervous system (CNS). Regulation of the Nogo-A/NgR1 pathway facilitates functional recovery and neural repair after spinal cord trauma and ...
Altea Soto +5 more
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Biomedicines, 2022 The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes,
Rodrigo M. Maza +7 more
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Nature Communications, 2022 Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural ...
Wenlu Li +20 more
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Hypothermic neuroprotection [PDF]
Neurotherapeutics, 2006 The possibility that hypothermia during or after resuscitation from asphyxia at birth, or cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very long time. It is now known that severe hypoxia-ischemia may not necessarily cause immediate cell death, but can precipitate a complex biochemical cascade leading to the ...
Gunn, AJ, Thoresen, M
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Mitophagy and Neuroprotection [PDF]
Trends in Molecular Medicine, 2020 Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms.
Lou, Guofeng +5 more
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Archives of Neurology, 2007 The ability of pharmacological agents to limit secondary biochemical damage and cell death has been well established in numerous animal models of stroke, head injury, and spinal cord injury, yet the results of such neuroprotective treatment strategies in human injury have been disappointing.
Alan I, Faden, Bogdan, Stoica
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O-GlcNAcylation is essential for therapeutic mitochondrial transplantation
Communications Medicine, 2023 Background Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations in safety and efficacy because mitochondria are vulnerable in extracellular ...
Ji Hyun Park +11 more
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British Medical Bulletin, 2000 Thrombolysis improves stroke outcome, but is applicable to a limited number of patients. Neuroprotection has the prospect to be universally offered, either alone or in combination with thrombolysis. Potential drug targets include elements of the excitotoxic glutamate cascade, calcium entry, intracellular protease activation, free radical damage, the ...
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Data in Brief, 2020 This article provides information regarding the effect of four common high abundant protein (albumin and immunoglobulins (Ig)) depletion strategies upon serum proteomics datasets derived from normal, non-diseased rat or human serum. After tryptic digest,
Bharani Thangavelu +4 more
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Perinatal neuroprotection [PDF]
F1000Prime Reports, 2014 Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children.
Salmeen, Kirsten E. +2 more
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