Results 1 to 10 of about 184,954 (326)
Pharmaceuticals, 2022 Nogo-A protein is a key myelin-associated inhibitor of axonal growth, regeneration, and plasticity in the central nervous system (CNS). Regulation of the Nogo-A/NgR1 pathway facilitates functional recovery and neural repair after spinal cord trauma and ...
Altea Soto +5 more
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Biomedicines, 2022 The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes,
Rodrigo M. Maza +7 more
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Nature Communications, 2022 Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural ...
Wenlu Li +20 more
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O-GlcNAcylation is essential for therapeutic mitochondrial transplantation
Communications Medicine, 2023 Background Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations in safety and efficacy because mitochondria are vulnerable in extracellular ...
Ji Hyun Park +11 more
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Data in Brief, 2020 This article provides information regarding the effect of four common high abundant protein (albumin and immunoglobulins (Ig)) depletion strategies upon serum proteomics datasets derived from normal, non-diseased rat or human serum. After tryptic digest,
Bharani Thangavelu +4 more
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Mitochondrial surface coating with artificial lipid membrane improves the transfer efficacy
Communications Biology, 2022 A new approach is developed to promote mitochondria transfer and the efficacy by surface decoration of cationic and fusogenic lipids, DOTAP and DOPE, showing improved neuroprotection in vitro and in vivo.
Takafumi Nakano +4 more
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Liquid–liquid phase separation in synaptopathies
Neuroprotection, 2023 Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
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Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury
Frontiers in Cellular Neuroscience, 2018 Autophagy is an essential process of cellular waist clearance that becomes altered following spinal cord injury (SCI). Details on these changes, including timing after injury, underlying mechanisms, and affected cells, remain controversial.
Teresa Muñoz-Galdeano +7 more
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Journal of Neuroinflammation, 2019 Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are ...
Laurent Kremer +6 more
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Brain-to-cervical lymph node signaling after stroke
Nature Communications, 2019 Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate ...
Elga Esposito +12 more
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