Results 1 to 10 of about 123,067 (366)
Pharmaceuticals, 2022 Nogo-A protein is a key myelin-associated inhibitor of axonal growth, regeneration, and plasticity in the central nervous system (CNS). Regulation of the Nogo-A/NgR1 pathway facilitates functional recovery and neural repair after spinal cord trauma and ...
Altea Soto +5 more
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Nature Communications, 2022 Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural ...
Wenlu Li +20 more
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Biomedicines, 2022 The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes,
Rodrigo M. Maza +7 more
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O-GlcNAcylation is essential for therapeutic mitochondrial transplantation
Communications Medicine, 2023 Background Transplantation of mitochondria is increasingly explored as a novel therapy in central nervous system (CNS) injury and disease. However, there are limitations in safety and efficacy because mitochondria are vulnerable in extracellular ...
Ji Hyun Park +11 more
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A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.
New England Journal of Medicine, 2020 BACKGROUND High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm
Sandra E. Juul +27 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2020 Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
semanticscholar +1 more source
Mitochondrial surface coating with artificial lipid membrane improves the transfer efficacy
Communications Biology, 2022 A new approach is developed to promote mitochondria transfer and the efficacy by surface decoration of cationic and fusogenic lipids, DOTAP and DOPE, showing improved neuroprotection in vitro and in vivo.
Takafumi Nakano +4 more
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Polyphenols from Food and Natural Products: Neuroprotection and Safety
Antioxidants, 2020 Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties.
Rui F. M. Silva, L. Pogačnik
semanticscholar +1 more source
Modeling Microglia Activation and Inflammation-Based Neuroprotectant Strategies During Ischemic Stroke [PDF]
Bulletin of Mathematical Biology 83 (2021) 72, 2020 Neural inflammation immediately follows the onset of ischemic stroke. During this process, microglial cells can be activated into two different phenotypes: the M1 phenotype, which can worsen brain injury by producing pro-inflammatory cytokines; or the M2 phenotype, which can aid in long term recovery by producing anti-inflammatory cytokines.
arxiv +1 more source
Stroke, 2020 Supplemental Digital Content is available in the text. Background and Purpose— Small extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral ischemia in rodents and to ...
Chen Wang +16 more
semanticscholar +1 more source