Results 1 to 10 of about 208,629 (380)
NeuroprotectionRecent advances in neuroscience have illuminated the central role of glutamate dysregulation in various neurological disorders. The glutamatergic system has emerged as a central player in the pathophysiology of various neurological disorders.
Jorge Y. Magdaleno Roman +1 more
doaj +2 more sources
Pharmaceuticals, 2022 Nogo-A protein is a key myelin-associated inhibitor of axonal growth, regeneration, and plasticity in the central nervous system (CNS). Regulation of the Nogo-A/NgR1 pathway facilitates functional recovery and neural repair after spinal cord trauma and ...
Altea Soto +5 more
doaj +1 more source
Liquid–liquid phase separation in synaptopathies
Neuroprotection, 2023 Liquid–liquid phase separation has emerged as an important mechanism for regulating cell activity by promoting the formation of membrane‐less condensates.
Huihui Jiang, Haitao Wu
doaj +1 more source
Basic Research in Cardiology, 2021 Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments: remote ischaemic ...
S. Nizari +11 more
semanticscholar +1 more source
Biomedicines, 2022 The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes,
Rodrigo M. Maza +7 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
semanticscholar +1 more source
Nature Communications, 2022 Damaged brains try to repair themselves by producing neurons in areas where neurogenesis does not normally occur. Here, the authors show that brain endothelial cells provide microvesicle-encased signals that convert parenchymal astrocytes into neural ...
Wenlu Li +20 more
doaj +1 more source
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.
New England Journal of Medicine, 2020 BACKGROUND High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm
Sandra E. Juul +27 more
semanticscholar +1 more source
Polyphenols from Food and Natural Products: Neuroprotection and Safety
Antioxidants, 2020 Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties.
Rui F. M. Silva, L. Pogačnik
semanticscholar +1 more source
Neuroprotection by the Ketogenic Diet: Evidence and Controversies
Frontiers in Nutrition, 2021 The ketogenic diet (KD) is a high-fat low-carbohydrate diet that has been used for decades as a non-pharmacologic approach to treat metabolic disorders and refractory pediatric epilepsy.
S. Gough +3 more
semanticscholar +1 more source