Results 11 to 20 of about 183,131 (255)
Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring [PDF]
Journal of Neuroscience Methods 140, 1-2 (2004) 23-8, 2007 This report describes technical adaptations of a traumatic brain injury (TBI) model-largely inspired by Marmarou-in order to monitor microdialysis data and PtiO2 (brain tissue oxygen) before, during and after injury. We particularly focalize on our model
Bruno Palmier +16 more
core +2 more sources
Role of estrogen and other sex hormones in brain aging: Neuroprotection and DNA repair [PDF]
Frontiers in Aging Neuroscience, 2017 Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due ...
Gredilla, Ricardo +2 more
core +2 more sources
Microglia and neuroprotection [PDF]
Journal of Neurochemistry, 2015 AbstractMicroglia were first identified over a century ago, but our knowledge about their ontogeny and functions has significantly expanded only recently. Microglia colonize the central nervous system (CNS) in utero and play essential roles in brain development.
Zhihong Chen, Bruce D. Trapp
openaire +4 more sources
Basic Research in Cardiology, 2021 Stroke remains one of the most common causes of death and disability worldwide. Several preclinical studies demonstrated that the brain can be effectively protected against ischaemic stroke by two seemingly distinct treatments: remote ischaemic ...
S. Nizari +11 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2020 Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
semanticscholar +1 more source
A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants.
New England Journal of Medicine, 2020 BACKGROUND High-dose erythropoietin has been shown to have a neuroprotective effect in preclinical models of neonatal brain injury, and phase 2 trials have suggested possible efficacy; however, the benefits and safety of this therapy in extremely preterm
Sandra E. Juul +27 more
semanticscholar +1 more source
Polyphenols from Food and Natural Products: Neuroprotection and Safety
Antioxidants, 2020 Polyphenols are naturally occurring micronutrients that are present in many food sources. Besides being potent antioxidants, these molecules may also possess anti-inflammatory properties.
Rui F. M. Silva, L. Pogačnik
semanticscholar +1 more source
Modeling Microglia Activation and Inflammation-Based Neuroprotectant Strategies During Ischemic Stroke [PDF]
Bulletin of Mathematical Biology 83 (2021) 72, 2020 Neural inflammation immediately follows the onset of ischemic stroke. During this process, microglial cells can be activated into two different phenotypes: the M1 phenotype, which can worsen brain injury by producing pro-inflammatory cytokines; or the M2 phenotype, which can aid in long term recovery by producing anti-inflammatory cytokines.
arxiv +1 more source
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
Translational Neurodegeneration, 2020 Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease.
Luodan Yang +3 more
semanticscholar +1 more source
Influence of pathogenic stimuli on Müller cell transfection by lipoplexes [PDF]
, 2020 Neuroprotection is a mutation-independent therapeutic strategy that seeks to enhance the survival of neuronal cell types through delivery of neuroprotective factors.
De Smedt, Stefaan +5 more
core +1 more source