Results 11 to 20 of about 184,954 (326)

Neuroprotection Targeting Protein Misfolding on Chronic Cerebral Hypoperfusion in the Context of Metabolic Syndrome [PDF]

, 2018
Metabolic syndrome (MetS) is a cluster of risk factors that lead to microvascular dysfunction and chronic cerebral hypoperfusion (CCH). Long-standing reduction in oxygen and energy supply leads to brain hypoxia and protein misfolding, thereby linking CCH
María Inés Herrera, Lucas Udovin, Nicolás Toro-Urrego, Carlos F. Kusnier, Juan Pablo Luaces, Matilde Otero‐Losada, Francisco Capani   +6 more
openalex   +4 more sources

Hypothermic neuroprotection [PDF]

Neurotherapeutics, 2006
The possibility that hypothermia during or after resuscitation from asphyxia at birth, or cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very long time. It is now known that severe hypoxia-ischemia may not necessarily cause immediate cell death, but can precipitate a complex biochemical cascade leading to the ...
Gunn, AJ, Thoresen, M
openaire   +2 more sources

Mitophagy and Neuroprotection [PDF]

Trends in Molecular Medicine, 2020
Neurodegenerative diseases are strongly age-related and currently cannot be cured, with a surge of patient numbers in the coming decades in view of the emerging worldwide ageing population, bringing healthcare and socioeconomic challenges. Effective therapies are urgently needed, and are dependent on new aetiological mechanisms.
Lou, Guofeng, Palikaras, Konstantinos, Lautrup, Sofie, Scheibye-Knudsen, Morten, Tavernarakis, Nektarios, Fang, Evandro F.   +5 more
openaire   +4 more sources

Neuroprotection [PDF]

Archives of Neurology, 2007
The ability of pharmacological agents to limit secondary biochemical damage and cell death has been well established in numerous animal models of stroke, head injury, and spinal cord injury, yet the results of such neuroprotective treatment strategies in human injury have been disappointing.
Alan I, Faden, Bogdan, Stoica
openaire   +4 more sources

Neuroprotection [PDF]

British Medical Bulletin, 2000
Thrombolysis improves stroke outcome, but is applicable to a limited number of patients. Neuroprotection has the prospect to be universally offered, either alone or in combination with thrombolysis. Potential drug targets include elements of the excitotoxic glutamate cascade, calcium entry, intracellular protease activation, free radical damage, the ...
openaire   +4 more sources

Perinatal neuroprotection [PDF]

F1000Prime Reports, 2014
Fetal or neonatal brain injury can result in lifelong neurologic disability. The most significant risk factor for perinatal brain injury is prematurity; however, in absolute numbers, full-term infants represent the majority of affected children.
Salmeen, Kirsten E., Jelin, Angie C., Thiet, Mari-Paule   +2 more
openaire   +2 more sources

rLOAD: does sex mediate the effect of acute antiplatelet loading on stroke outcome. [PDF]

, 2014
BackgroundBiologic sex can influence response to pharmacologic therapy. The purpose of this proof-of-concept study was to evaluate the medicating effects of estrogen in the efficacy of acute antiplatelet loading therapy on stroke outcome in the rabbit ...
Compton, M Peggy, Eastwood, Jo-Ann, Gylys, Karen, Meyer, Dawn M, Zivin, Justin A   +4 more
core   +6 more sources

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden [PDF]

, 2010
Background It has traditionally been thought that the pathological accumulation of tau in Alzheimer's disease and other tauopathies facilitates neurodegeneration, which in turn leads to cognitive impairment.
A de Calignon, AD Mosnaim, Amelia G Johnson, B Reisberg, B Zhang, CA Dickey, CA Dickey, Chad A Dickey, Clara Kraft, Edwin J Weeber, EM Sigurdsson, Erin E Congdon, F van Bebber, HM Hassan, I Walter-Sack, J Lewis, Jason E Gestwicki, Jeffrey R Jones, John C O'Leary, John Koren, Jose F Abisambra, K Santacruz, Karen E Duff, Laura J Blair, M Necula, M Oz, Melinda Peters, MJ West, ML Smith, MP Mazanetz, Paul Marinec, Qingyou Li, RS Doody, S Deiana, S Taniguchi, TL Spires-Jones, TM Visarius, UK Jinwal, Umesh K Jinwal   +38 more
core   +6 more sources

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]

, 2015
Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D, Bainbridge, A, Cady, E, Charles-Edwards, G, Deierl, A, Edwards, AD, Fagiolo, G, Franks, NP, Griffiths, J, Hajnal, J, Juszczak, E, Kapetanakis, B, Linsell, L, Maze, M, Omar, O, Robertson, NJ, Strohm, B, Tusor, N   +17 more
core   +2 more sources

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
The authors acknowledge the support of the Barts and the London Charity, the Multiple Sclerosis Society of Great Britain and Northern Ireland, the National Multiple Sclerosis Society, USA, notably the National Centre for the Replacement, Refinement ...
A Compston, AJ Coles, BB Thomas, C Bjartmar, CKS Leung, D Baker, DA Bechtold, David Baker, DB Fernandes, DW Hampton, E Bettelli, E Bettelli, F Hafezi, G Feng, G Pryce, Gavin Giovannoni, J Goverman, J Oh, JA Black, JA Cohen, JK O’Neill, JM Coquet, K Raju, Katie Lidster, KM Galetta, L Steinman, LS Talman, LS Talman, M Kleinewietfeld, Mark D. Baker, MM Morris-Downes, Pablo Villoslada, Pete Coffey, Peter Munro, R Dutta, R Kapoor, S Al-Izki, S Al-Izki, S Al-Izki, S Gnanapavan, S Mader, Samuel J. Jackson, SG Waxman, SJ Piddlesden, T Hayton, T Svingen, X Wang, Y Guan, Z Ahmed, Zubair Ahmed   +49 more
core   +14 more sources