Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease [PDF]
, 2015 Date of Acceptance: 28/07/2015 The authors are grateful to the staff of the Medical Research Facility for their help with the animal care. This work was supported by the NHS Endowment fund 09/03 and the Wellcome Trust (WT080782MF).
Mounsey, Ross B +6 more
core +1 more source
Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
Translational Neurodegeneration, 2020 Mitochondrial dysfunction plays a central role in the formation of neuroinflammation and oxidative stress, which are important factors contributing to the development of brain disease.
Luodan Yang +3 more
semanticscholar +1 more source
Neuroprotection and antioxidants
Neural Regeneration Research, 2016 Ischemia as a serious neurodegenerative disorder causes together with reperfusion injury many changes in nervous tissue. Most of the neuronal damage is caused by complex of biochemical reactions and substantial processes, such as protein agregation, reactions of free radicals, insufficient blood supply, glutamate excitotoxicity, and oxidative stress ...
Viera Danielisová, Maria Lalkovicova
openaire +4 more sources
Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]
, 2015 Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D +17 more
core +2 more sources
Microglia and neuroprotection [PDF]
Journal of Neurochemistry, 2016 AbstractMicroglia were first identified over a century ago, but our knowledge about their ontogeny and functions has significantly expanded only recently. Microglia colonize the central nervous system (CNS) in utero and play essential roles in brain development.
Zhihong Chen, B. Trapp
semanticscholar +4 more sources
Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration [PDF]
, 2010 Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
A Berna-Erro +84 more
core +6 more sources
Influence of pathogenic stimuli on Müller cell transfection by lipoplexes [PDF]
, 2020 Neuroprotection is a mutation-independent therapeutic strategy that seeks to enhance the survival of neuronal cell types through delivery of neuroprotective factors.
De Smedt, Stefaan +5 more
core +1 more source
The APCs of neuroprotection [PDF]
Journal of Clinical Investigation, 2009 Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant activated protein C (APC) is able to cross the blood-spinal cord barrier in mice and signal to both neuronal and non-neuronal cells ...
Charles T. Esmon, Jonathan D. Glass
openaire +3 more sources
Role of estrogen and other sex hormones in brain aging: Neuroprotection and DNA repair [PDF]
, 2017 Aging is an inevitable biological process characterized by a progressive decline in physiological function and increased susceptibility to disease. The detrimental effects of aging are observed in all tissues, the brain being the most important one due ...
Gredilla, Ricardo +2 more
core +1 more source
Inflammation and neuroprotection in traumatic brain injury.
JAMA Neurology, 2015 IMPORTANCE Traumatic brain injury (TBI) is a significant public health concern that affects individuals in all demographics. With increasing interest in the medical and public communities, understanding the inflammatory mechanisms that drive the ...
Kara N. Corps +2 more
semanticscholar +1 more source