Results 31 to 40 of about 134,809 (339)
Stroke, 2020 Supplemental Digital Content is available in the text. Background and Purpose— Small extracellular vesicles (sEVs) obtained from mesenchymal stromal cells (MSCs) were shown to induce neurological recovery after focal cerebral ischemia in rodents and to ...
Chen Wang +16 more
semanticscholar +1 more source
Indian Journal of Ophthalmology, 2011 Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells and their axons. Recent evidence suggests that intraocular pressure (IOP) is only one of the many risk factors for this disease. Current treatment options for this disease have been limited to the reduction of IOP; however, it is clear now that the disease ...
Jonathan G Crowston +2 more
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Mitochondrial surface coating with artificial lipid membrane improves the transfer efficacy
Communications Biology, 2022 A new approach is developed to promote mitochondria transfer and the efficacy by surface decoration of cationic and fusogenic lipids, DOTAP and DOPE, showing improved neuroprotection in vitro and in vivo.
Takafumi Nakano +4 more
doaj +1 more source
Neuroprotection and antioxidants
Neural Regeneration Research, 2016 Ischemia as a serious neurodegenerative disorder causes together with reperfusion injury many changes in nervous tissue. Most of the neuronal damage is caused by complex of biochemical reactions and substantial processes, such as protein agregation, reactions of free radicals, insufficient blood supply, glutamate excitotoxicity, and oxidative stress ...
Viera Danielisová, Maria Lalkovicova
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Journal of Neuroinflammation, 2019 Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are ...
Laurent Kremer +6 more
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Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats
Biology, 2022 Introduction Cardiac arrest (CA) and resuscitation induces global cerebral ischemia and reperfusion, causing neurologic deficits or death. Manganese porphyrins, superoxide dismutase mimics, are reportedly able to effectively reduce ischemic injury in ...
Peng Wang +10 more
doaj +1 more source
Brain-to-cervical lymph node signaling after stroke
Nature Communications, 2019 Brain damage induces systemic inflammation, but insights and implication of this induction is still unclear. Here the authors show, using rat and mouse focal cerebral ischemia models, that the damaged brain signals via the VEGF-C/VEFGR3 axis to activate ...
Elga Esposito +12 more
doaj +1 more source
Microglia and neuroprotection [PDF]
Journal of Neurochemistry, 2016 AbstractMicroglia were first identified over a century ago, but our knowledge about their ontogeny and functions has significantly expanded only recently. Microglia colonize the central nervous system (CNS) in utero and play essential roles in brain development.
Zhihong Chen, B. Trapp
semanticscholar +4 more sources
Progesterone and neuroprotection [PDF]
Hormones and Behavior, 2013 Numerous studies aimed at identifying the role of estrogen on the brain have used the ovariectomized rodent as the experimental model. And while estrogen intervention in these animals has, at least partially, restored cholinergic, neurotrophin and cognitive deficits seen in the ovariectomized animal, it is worth considering that the removal of the ...
Meharvan Singh, Chang Su
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The APCs of neuroprotection [PDF]
Journal of Clinical Investigation, 2009 Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant activated protein C (APC) is able to cross the blood-spinal cord barrier in mice and signal to both neuronal and non-neuronal cells ...
Charles T. Esmon, Jonathan D. Glass
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