Results 31 to 40 of about 184,954 (326)

Neuroprotection in glaucoma

Journal of Ophthalmic and Vision Research, 2016
Glaucoma is a degenerative optic neuropathy characterized by retinal ganglion cell (RGC) loss and visual field defects. It is known that in some glaucoma patients, death of RGCs continues despite intraocular pressure (IOP) reduction. Neuroprotection in the field of glaucoma is defined as any treatment, independent of IOP reduction, which prevents RGC ...
Azadeh Doozandeh, Shahin Yazdani
openaire   +3 more sources

Characteristics of primary rat microglia isolated from mixed cultures using two different methods

Journal of Neuroinflammation, 2017
Background Microglial cultures comprise a critically important model system for investigating inflammatory mechanisms in almost all CNS disorders. Mild trypsinization and shaking are the two most commonly used methods to isolate primary microglia from ...
Li Lin, Rakhi Desai, Xiaoying Wang, Eng H. Lo, Changhong Xing   +4 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source

Adrenomedullin promotes differentiation of oligodendrocyte precursor cells into myelin-basic-protein expressing oligodendrocytes under pathological conditions in vitro

Stem Cell Research, 2015
Oligodendrocytes, which are the main cell type in cerebral white matter, are generated from their precursor cells (oligodendrocyte precursor cells: OPCs).
Takakuni Maki, Yoko Takahashi, Nobukazu Miyamoto, Anna C. Liang, Masafumi Ihara, Eng H. Lo, Ken Arai   +6 more
doaj   +1 more source

Manganese Porphyrin Promotes Post Cardiac Arrest Recovery in Mice and Rats

Biology, 2022
Introduction Cardiac arrest (CA) and resuscitation induces global cerebral ischemia and reperfusion, causing neurologic deficits or death. Manganese porphyrins, superoxide dismutase mimics, are reportedly able to effectively reduce ischemic injury in ...
Peng Wang, Ying Li, Baihui Yan, Zhong Yang, Litao Li, Zhipeng Cao, Xuan Li, Ines Batinic-Haberle, Ivan Spasojevic, David S. Warner, Huaxin Sheng   +10 more
doaj   +1 more source

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]

, 2013
Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core   +1 more source

Disruption of Sema3A/Plexin‐A1 inhibitory signalling in oligodendrocytes as a therapeutic strategy to promote remyelination

EMBO Molecular Medicine, 2019
Current treatments in multiple sclerosis (MS) are modulating the inflammatory component of the disease, but no drugs are currently available to repair lesions.
Fabien Binamé, Lucas D Pham‐Van, Caroline Spenlé, Valérie Jolivel, Dafni Birmpili, Lionel A Meyer, Laurent Jacob, Laurence Meyer, Ayikoé G Mensah‐Nyagan, Chrystelle Po, Michaël Van der Heyden, Guy Roussel, Dominique Bagnard   +12 more
doaj   +1 more source

Neuroprotective mushrooms

NeuroImmune Pharmacology and Therapeutics
Abstract Objectives Alternative medicines commonly supplement or, at times, replace standard medical treatment. One area of increasing attention is disease-modifying medicines for neurodegenerative diseases.
Mai M. Abdelmoaty, Rana Kadry, R. Lee Mosley, Howard E. Gendelman   +3 more
openaire   +2 more sources

Electrosynthesis of Bioactive Chemicals, From Ions to Pharmaceuticals

Advanced Functional Materials, EarlyView.
This review discusses recent advances in electrosynthesis for biomedical and pharmaceutical applications. It covers key electrochemical materials enabling precise delivery of ions and small molecules for cellular modulation and disease treatment, alongside catalytic systems for pharmaceutical synthesis.
Gwangbin Lee, Sojin Kim, Myeongeun Lee, Kyoungsuk Jin, Jimin Park   +4 more
wiley   +1 more source

Role of Epigenetic Modulation in Neurodegenerative Diseases: Implications of Phytochemical Interventions

Antioxidants
Epigenetics defines changes in cell function without involving alterations in DNA sequence. Neuroepigenetics bridges neuroscience and epigenetics by regulating gene expression in the nervous system and its impact on brain function.
Mani Iyer Prasanth, Bhagavathi Sundaram Sivamaruthi, Clerance Su Yee Cheong, Kanika Verma, Tewin Tencomnao, James Michael Brimson, Anchalee Prasansuklab   +6 more
doaj   +1 more source