Results 41 to 50 of about 183,131 (255)

The APCs of neuroprotection [PDF]

Journal of Clinical Investigation, 2009
Mutations in the enzyme superoxide dismutase 1 (SOD1) have been linked to the neurodegenerative disease amyotrophic lateral sclerosis (ALS). In this issue of the JCI, Zhong et al. report that the endogenous anticoagulant activated protein C (APC) is able to cross the blood-spinal cord barrier in mice and signal to both neuronal and non-neuronal cells ...
Charles T. Esmon, Jonathan D. Glass
openaire   +3 more sources

Neurogenetics of the Human Adenosine Receptor Genes: Genetic Structures and Involvement in Brain Diseases [PDF]

Journal of Caffeine and Adenosine Research, New Rochelle, N.Y. : Mary Ann Liebert, Inc., [2018]-, 2019, 9 (3), pp.73-88, 2020
Adenosine receptors are G-protein-coupled receptors involved in a wide range of physiological and pathological phenomena in most mammalian systems. All four receptors are widely expressed in the central nervous system, where they modulate neurotransmitter release and neuronal plasticity. A large number of gene association studies have shown that common
arxiv   +1 more source

Curcumin, Gut Microbiota, and Neuroprotection

Nutrients, 2019
Curcumin, a nontoxic, naturally occurring polyphenol, has been recently proposed for the management of neurodegenerative and neurological diseases. However, a discrepancy exists between the well-documented pharmacological activities that curcumin seems ...
Francesco Di Meo, S. Margarucci, U. Galderisi, S. Crispi, G. Peluso   +4 more
semanticscholar   +1 more source

Moderate hypothermia within 6 h of birth plus inhaled xenon versus moderate hypothermia alone after birth asphyxia (TOBY-Xe): a proof-of-concept, open-label, randomised controlled trial [PDF]

, 2015
Background Moderate cooling after birth asphyxia is associated with substantial reductions in death and disability, but additional therapies might provide further benefit.
Azzopardi, D, Bainbridge, A, Cady, E, Charles-Edwards, G, Deierl, A, Edwards, AD, Fagiolo, G, Franks, NP, Griffiths, J, Hajnal, J, Juszczak, E, Kapetanakis, B, Linsell, L, Maze, M, Omar, O, Robertson, NJ, Strohm, B, Tusor, N   +17 more
core   +2 more sources

Detection of preventable fetal distress during labor from scanned cardiotocogram tracings using deep learning [PDF]

, 2021
Despite broad application during labor and delivery, there remains considerable debate about the value of electronic fetal monitoring (EFM). EFM includes the surveillance of the fetal heart rate (FHR) patterns in conjunction with the maternal uterine contractions providing a wealth of data about fetal behavior and the threat of diminished oxygenation ...
arxiv   +1 more source

Bench-to-bedside review: Erythropoietin and its derivatives as therapies in critical care [PDF]

, 2012
Author can archive publisher's pdf. Free via Creative Commons: CC-BENCHTOBEDSIDE-2.0.
Nandra, KK, Patel, NSA, Thiemermann, C
core   +1 more source

Targeting NMDA receptors in stroke: new hope in neuroprotection

Molecular Brain, 2018
NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments.
Qiu Jing Wu, M. Tymianski
semanticscholar   +1 more source

Post-stroke inhibition of induced NADPH oxidase type 4 prevents oxidative stress and neurodegeneration [PDF]

, 2010
Ischemic stroke is the second leading cause of death worldwide. Only one moderately effective therapy exists, albeit with contraindications that exclude 90% of the patients.
A Berna-Erro, A Bobba, A. A Miller, Ajay M. Shah, Alexander M. Herrmann, Anja Schrewe, B. D Watson, C Kleinschnitz, C Kleinschnitz, C Kleinschnitz, C Kleinschnitz, C Kleinschnitz, C Stielow, C. E Walder, Christian Geis, Christoph Kleinschnitz, David Barit, E. S Flamm, E. S Sena, Emma Jones, G Gavazzi, G. S Omenn, Guido Stoll, H Chen, H ten Freyhaus, H. B van der Worp, H. B van der Worp, Harald H. H. W. Schmidt, Helmut Fuchs, Henrike Grund, J. S Elkins, K Block, K Matsuno, K Murakami, K Whalley, K. A Jackman, K. E Sandoval, K. K Griendling, K. P Loh, Karin Jandeleit-Dahm, Kirstin Wingler, Konstanze Barthel, Lore Becker, M Austinat, M Elvers, M Fisher, M Geiszt, M Mittal, M Pham, M Schroeter, M. D Ginsberg, M. J Eliasson, M. R Macleod, Malcolm McLeod, Manish Mittal, Martin Hrabé de Angelis, Melanie E. Armitage, Michael K. Schuhmann, N Anilkumar, N Opitz, N. A Crossley, Norbert Weissmann, P Niethammer, P Vallet, Peter Kraft, R. M Touyz, S Heumuller, S Lange, S. G Meuth, S. G Meuth, S. K McCann, S. R Steinhubl, Sabine Meurer, Sven G. Meuth, T Schluter, Thomas Klopstock, Tobias Schwarz, U Dirnagl, U Dirnagl, U Landmesser, V. E O'Collins, Valérie Gailus-Durner, W. P Wu, Y Dotan, Z Veresh   +84 more
core   +6 more sources

Effects of anesthesia on cerebral blood flow, metabolism, and neuroprotection

Journal of Cerebral Blood Flow and Metabolism, 2018
Administration of anesthetic agents fundamentally shifts the responsibility for maintenance of homeostasis from the patient and their intrinsic physiological regulatory mechanisms to the anesthesiologist.
Andrew M. Slupe, J. Kirsch
semanticscholar   +1 more source

Neuroprotection in glaucoma [PDF]

Cell and Tissue Research, 2013
Glaucoma is a frequent eye disease in the elderly and the second leading cause of irreversible blindness both in developed and developing countries (Resnikoff et al. 2004). Presently, about 50 million people are blind from glaucoma worldwide, a number that has not significantly changed over the last decade (Resnikoff et al. 2004; Thylefors et al. 1995).
Franz Grehn, Norbert Pfeiffer, Ernst R. Tamm   +2 more
openaire   +3 more sources