Results 31 to 40 of about 5,017 (139)

Moutan Cortex Extract Mediates Diabetic Retinopathy by Blocking the ROS‑Triggered HIF‐1α/VEGF Axis in Retinal Pigment Epithelial Cells

open access: yeseFood, Volume 7, Issue 4, August 2026.
Schematic diagram of the mechanism by which Moutan Cortex extract (MCE) ameliorates DR. MCE alleviates retinal structural damage and reduces neovascular lesions by downregulating the ROS/HIF‐1α/VEGF signaling axis. ABSTRACT Moutan Cortex is a functional food ingredient with multiple health benefits, but its effects on diabetic retinopathy (DR) remain ...
Mei‐rong Li   +13 more
wiley   +1 more source

Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis

open access: yesOilseeds and fats, crops and lipids, 2015
The retina is responsible for coding the light stimulus into a nervous signal that is transferred to the brain via the optic nerve. The retina is formed by the association of the neurosensory retina and the retinal pigment epithelium that is supported by
Fourgeux Cynthia   +5 more
doaj   +1 more source

A new surgical technique using steel suture for trans-scleral fixation of posterior chamber intraocular lenses

open access: yesIndian Journal of Ophthalmology, 2013
Background: A new emerging complication of trans-scleral fixation of posterior chamber (PC) intraocular lens (IOL) with polypropylene suture is high rates of spontaneous dislocation of the IOL due to disintegration or breakage of suture.
Jagat Ram   +3 more
doaj   +1 more source

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

open access: yesJournal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva   +5 more
wiley   +1 more source

L-DOPA is an endogenous ligand for OA1.

open access: yesPLoS Biology, 2008
Albinism is a genetic defect characterized by a loss of pigmentation. The neurosensory retina, which is not pigmented, exhibits pathologic changes secondary to the loss of pigmentation in the retina pigment epithelium (RPE).
Vanessa M Lopez   +4 more
doaj   +1 more source

Dietary and lifestyle risk factors associated with age-related macular degeneration: A hospital based study

open access: yesIndian Journal of Ophthalmology, 2013
Aim : To establish the frequency, associations and risk factors for age-related macular degeneration (AMD) in hospital population of South India. Materials and Methods : In this cross-sectional hospital based study, 3549 subjects (2090 men and 1459 women)
Bhatiwada Nidhi   +4 more
doaj   +1 more source

Unveiling a New Link: Cholesterol Deficiency in Smith–Lemli–Opitz and Niemann–Pick C as a Driver of Ciliopathies

open access: yesAmerican Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1179-1191, June 2026.
ABSTRACT The ciliopathies are a group of genetic disorders caused by defective function of either the primary cilia (a large number) or the motile cilia (a much smaller number). These have been defined as diseases with mutations in genes encoding individual ciliary or cilia‐associated proteins.
Robert P. Erickson   +1 more
wiley   +1 more source

A supramolecular assembly of cone‐specific G‐protein and cryptochrome 4a on lipid bilayer

open access: yesThe FEBS Journal, Volume 293, Issue 11, Page 3362-3375, June 2026.
Immobilized phospholipid bilayers on a sensor chip surface serve as membrane platform to investigate critical protein–lipid and protein–protein interaction processes by surface plasmon resonance. The putative magnetoreceptor cryptochrome 4a and the myristoylated cone‐specific G‐protein α‐subunit (Gtα) bind with high affinity to immobilized lipid ...
Ümmügülsüm Güzelsoy‐Flügge   +3 more
wiley   +1 more source

Design, fabrication and evaluation of the cell micro-injector for improvement of the quality of subretinal space injection with minimum damage

open access: yesمجله علمی دانشگاه علوم پزشکی کردستان, 2021
Background and Aim: An accurate cell injection in therapeutic methods is one of the most important and challenging stages in animal and human cell therapy.
Hamid Aboutaleb Kadkhodaeian   +3 more
doaj  

Ophthalmic Vascular Occlusion and Blindness After Platelet‐Rich Plasma Injections: A Systematic Review

open access: yesJournal of Cosmetic Dermatology, Volume 25, Issue 6, June 2026.
ABSTRACT Background Platelet‐rich plasma (PRP) is widely used in aesthetic and regenerative medicine; however, rare vision‐threatening complications such as blindness have been reported following facial injections. Aims This systematic review aimed to identify and analyze all published cases of visual impairment following PRP injections.
Mandana Ebrahimzade   +6 more
wiley   +1 more source

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