Results 11 to 20 of about 5,170 (138)

Chrysin attenuates diabetes-induced retinal injury by inhibiting microglial GBP3/NLRP3/GSDMD-mediated pyroptosis. [PDF]

Animal Model Exp Med
We investigated the therapeutic potential and mechanism of chrysin in experimental diabetic retinal disease. Using a streptozotocin (STZ)‐induced diabetic mouse model and high‐glucose‐stimulated BV2 microglia, we revealed chrysin‐responsive pyroptosis‐associated signatures and identified GBP3 as a regulated node.
Liu Q, Wang SM, Chen X, You YR, Guo CJ, Xie CQ, Wang LL, Liu Q, Zhang L, Yang JT.   +9 more
europepmc   +2 more sources

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Caspase-8, -12, and -3 Activation by 7-Ketocholesterol in Retinal Neurosensory Cells

Investigative Opthalmology & Visual Science, 2007
To determine the caspase pathways involved with 7-ketocholesterol (7kCh)-induced apoptosis in rat R28 cells.R28 cells were exposed to 7kCh with or without low-density lipoprotein (LDL) and z-VAD-fmk, a pan-caspase inhibitor. Cell viability was measured by a trypan blue dye exclusion assay.
Aneesh, Neekhra, Saurabh, Luthra, Marilyn, Chwa, Gail, Seigel, Ana L, Gramajo, Baruch D, Kuppermann, M Cristina, Kenney   +6 more
openaire   +2 more sources

NLRP3 and autophagy in retinal ganglion cell inflammation in age-related macular degeneration: potential therapeutic implications [PDF]

International Journal of Ophthalmology
Retinal degenerative diseases were a large group of diseases characterized by the primary death of retinal ganglion cells (RGCs). Recent studies had shown an interaction between autophagy and nucleotide-binding oligomerization domain-like receptor 3 ...
Xiao-Li Wang, Yun-Xia Gao, Qiong-Zhen Yuan, Ming Zhang   +3 more
doaj   +1 more source

Microfluidic and Microscale Assays to Examine Regenerative Strategies in the Neuro Retina

Micromachines, 2020
Bioengineering systems have transformed scientific knowledge of cellular behaviors in the nervous system (NS) and pioneered innovative, regenerative therapies to treat adult neural disorders.
Maribel Vazquez
doaj   +1 more source

Histopathological characterisation of retinal lesions associated to Diplostomum species (Platyhelminthes: Trematoda) infection in polymorphic Arctic charr Salvelinus alpinus

International Journal for Parasitology: Parasites and Wildlife, 2018
The eye represents an immune privileged organ where parasites can escape host reactions. This study provides the first systematic evidence of the pathology associated with Diplostomum sp. infection in the eye retina of fish (i.e.
F. Padrós, R. Knudsen, I. Blasco-Costa
doaj   +1 more source

Dynamics of change glioneyronal complex retinal photodamage, usingmathematical modeling methods

Бюллетень сибирской медицины, 2012
Using electron microscopy and morphometric analysis studied the structural changes of neurons and radial glia of the retina of white mongrel male rats when exposed to light (6000 lux) in the dynamics after 1, 7, 14 and 30 days.
Ye. Yu. Varakuta, A. V. Potapov, A. A. Zhdankina, M. V. Svetlik, Ye. P. Mikhulya, S. V. Logvinov, A. V. Gerasimov   +6 more
doaj   +1 more source

Molecular characterization of MAP9 in the photoreceptor sensory cilia as a modifier in canine RPGRIP1-associated cone-rod dystrophy

Frontiers in Cellular Neuroscience, 2023
Photoreceptors possess a highly specialized primary cilium containing expanded ciliary membrane discs called the outer segment. The photoreceptor cilium is essential for the maintenance of the outer segment, and pathogenic variants in more than 50 cilia ...
Kei Takahashi, Jennifer C. Kwok, Yu Sato, Gustavo D. Aguirre, Keiko Miyadera   +4 more
doaj   +1 more source

Zika Infection Disrupts Proteins Involved in the Neurosensory System

Frontiers in Cell and Developmental Biology, 2020
Newly re-emerging viruses are of great global concern, especially when there are no therapeutic interventions available during the time of an outbreak.
Kathleen K. M. Glover, Kathleen K. M. Glover, Ali Zahedi-Amiri, Ali Zahedi-Amiri, Ying Lao, Victor Spicer, Thomas Klonisch, Thomas Klonisch, Thomas Klonisch, Kevin M. Coombs, Kevin M. Coombs, Kevin M. Coombs   +11 more
doaj   +1 more source

Tracking the Transplanted Neurosphere in Retinal Pigment Epithelium Degeneration Model

Basic and Clinical Neuroscience, 2021
Introduction: Retinal Pigment Epithelium (RPE) layer deterioration is a leading cause of Age-Related Macular Degeneration (AMD), i.e., the most significant reason for irreversible blindness.
Hamid Aboutaleb Kadkhodaeian, Amir Salati, Mojtaba Ansari, Vajihe Taghdiri Nooshabadi   +3 more
doaj