Preclinical Evaluation of Botulinum Toxin Type E (TrenibotulinumtoxinE) Using the Mouse Digit Abduction Score (DAS) Assay [PDF]
ToxinsTrenibotulinumtoxinE (trenibotE), a botulinum neurotoxin serotype E (BoNT/E), is being developed for clinical use, and can fill a unique treatment gap for patients who are seeking neurotoxin treatment with a rapid onset and short duration of effect. This
Gregory S. Nicholson +5 more
doaj +2 more sources
Development of a Recombinant Fusion Vaccine Candidate Against Lethal Clostridium botulinum Neurotoxin Types A and B [PDF]
VaccinesBackground: Botulinum neurotoxins (BoNTs), produced by Clostridium botulinum, are potent protein toxins that can cause botulism, which leads to death or neuroparalysis in humans by targeting the nervous system.
Eun-Sun Choi +7 more
doaj +2 more sources
Current status and future directions of botulinum neurotoxins for targeting pain processing. [PDF]
, 2015 Current evidence suggests that botulinum neurotoxins (BoNTs) A1 and B1, given locally into peripheral tissues such as skin, muscles, and joints, alter nociceptive processing otherwise initiated by inflammation or nerve injury in animal models and humans.
Pellett, Sabine +2 more
core +11 more sources
Retroform Cervical Dystonia: Target Muscle Selection and Efficacy of Botulinum Toxin Injection
Frontiers in Neurology, 2022 IntroductionRetroform cervical dystonia (RCD), which includes retrocaput and retrocollis, is a rare form of cervical dystonia. Few reports have been published on RCD.
Yaowen Hu +8 more
doaj +1 more source
Botulinum Neurotoxin Type A Directly Affects Sebocytes and Modulates Oleic Acid-Induced Lipogenesis
Toxins, 2022 Excess sebum (seborrhea) results in oily skin and is associated with large pore size and acne. Studies in healthy, seborrheic volunteers have reported that intradermal injection of commercial preparations of botulinum neurotoxin type A (BoNT/A ...
Karen Brami-Cherrier +5 more
doaj +1 more source
Correction: Steele et al. Misincorporation Proteomics Technologies: A Review. Proteomes 2021, 9, 2
Proteomes, 2022 In the original publication, there was a mistake in Table 2 as published [...]
Joel R. Steele +6 more
doaj +1 more source
Scientific Reports, 2021 Clostridium botulinum neurotoxin serotype A (BoNT/A) is a potent neurotoxin that serves as an effective therapeutic for several neuromuscular disorders via induction of temporary muscular paralysis.
Nicholas G. James +7 more
doaj +1 more source
Virtual prediction of potential immunogenic epitope of candoxin protein from Malayan krait (Bungarus candidus) venom [PDF]
Journal of Pharmacy & Pharmacognosy Research, 2022 Context: Malayan krait (Bungarus candidus) is a snake that is considered highly venomous snake and widely distributed across Southeast Asia. Envenomation by this snake is characterized by facial weakness, paralysis, respiratory muscle weakness, and in ...
Rahmat Grahadi +2 more
doaj +1 more source
Kinect-based objective evaluation of bradykinesia in patients with Parkinson's disease
Digital Health, 2023 Objective To quantify bradykinesia in Parkinson's disease (PD) with a Kinect depth camera-based motion analysis system and to compare PD and healthy control (HC) subjects. Methods Fifty PD patients and twenty-five HCs were recruited.
Zhuang Wu +15 more
doaj +1 more source
Misincorporation Proteomics Technologies: A Review
Proteomes, 2021 Proteinopathies are diseases caused by factors that affect proteoform conformation. As such, a prevalent hypothesis is that the misincorporation of noncanonical amino acids into a proteoform results in detrimental structures.
Joel R. Steele +6 more
doaj +1 more source