Results 171 to 180 of about 65,558 (345)

NEUROTOXINS FROM INVERTEBRATES AS ALTERNATIVE THERAPEUTIC AGENTS AND TOOLS IN BASIC RESEARCH

open access: yesVitae, 2009
Animal venoms are a complex mixture of proteins, peptides, enzymes and trace elements such as carbohydrates and salts, which aim to immobilize the prey and begin digestion.
Jaime A. PEREAÑEZ, Leidy J. VARGAS
doaj  

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

open access: yesCancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan   +13 more
wiley   +1 more source

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

open access: yesChemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb   +5 more
wiley   +1 more source

Macrocycles of Saxitoxin: Insights into the Structure of Zetekitoxin AB

open access: yesChemBioChem, EarlyView.
Synthetic macrocycles of (+)‐saxitoxin, the causative agent of paralytic shellfish poisoning, have been prepared. These are designed to mimic the macrocyclic core of the proposed structure for zetekitoxin AB. Interestingly, these synthetic macrocycles do not form the C12 hydrate as commonly observed in this family of toxins, casting doubt on the ...
Wenyuan Li   +7 more
wiley   +1 more source

Insulin and Metformin are Associated With Reduced Risk of Amyotrophic Lateral Sclerosis

open access: yesChronic Diseases and Translational Medicine, EarlyView.
Human insulin heterodimer (A). Human insulin heterodimer (dark blue) docked within center of Cx43 channel (B) Abstract Background Type 2 diabetes (T2D), but not type 1, protected against amyotrophic lateral sclerosis (ALS). In T2D serum insulin is normal or elevated in the early stages.
Steven Lehrer, Peter H. Rheinstein
wiley   +1 more source

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