Results 21 to 30 of about 65,558 (345)

A summary index derived from Kinect to evaluate postural abnormalities severity in Parkinson’s Disease patients

npj Parkinson's Disease, 2022
Postural abnormalities are common disabling motor complications affecting patients with Parkinson’s disease (PD). We proposed a summary index for postural abnormalities (IPA) based on Kinect depth camera and explored the clinical value of this indicator.
Ronghua Hong, Tianyu Zhang, Zhuoyu Zhang, Zhuang Wu, Ao Lin, Xiaoyun Su, Yue Jin, Yichen Gao, Kangwen Peng, Lixi Li, Lizhen Pan, Hongping Zhi, Qiang Guan, Lingjing Jin   +13 more
doaj   +1 more source

Evaluation and Optimization of Microdrop Digital PCR for Detection of Serotype A and B Clostridium botulinum

Frontiers in Microbiology, 2022
Clostridium botulinum is the causative pathogen of botulism. Laboratory detection of C. botulinum is essential for clinical therapy treatment of botulism due to the difficulty in diagnosis, especially in infant botulism. The extreme toxicity of botulinum
Pengya Gao, Pengya Gao, Changde Wu, Jin Zhang, Shuping Wang, Ying Huang, Yinping Dong, Tingting Liu, Changyun Ye, Xuefang Xu, Wenwen Xin   +10 more
doaj   +1 more source

Two-component signal transduction system CBO0787/CBO0786 represses transcription from botulinum neurotoxin promoters in Clostridium botulinum ATCC 3502. [PDF]

PLoS Pathogens, 2013
Blocking neurotransmission, botulinum neurotoxin is the most poisonous biological substance known to mankind. Despite its infamy as the scourge of the food industry, the neurotoxin is increasingly used as a pharmaceutical to treat an expanding range of ...
Zhen Zhang, Hannu Korkeala, Elias Dahlsten, Elina Sahala, John T Heap, Nigel P Minton, Miia Lindström   +6 more
doaj   +1 more source

Behavioral Tests in Neurotoxin-Induced Animal Models of Parkinson’s Disease

Antioxidants, 2020
Currently, neurodegenerative diseases are a major cause of disability around the world. Parkinson’s disease (PD) is the second-leading cause of neurodegenerative disorder after Alzheimer’s disease.
Maruthi Prasad E, Shih-Ya Hung
semanticscholar   +1 more source

Resistance to cosmetic botulinum toxin A: A 15-patient case series across 12 sites [PDF]

JAAD International
Carlos G. Wambier, MD, PhD, Fatima N. Mirza, MD, MPH, Sarah P.F. Wambier, MD, PhD, Vince Bertucci, MD, Jean Carruthers, MD, Joely Kaufman, MD, John Martin, MD, J. Barton Sterling, MD, Flávia Brasileiro, MD, Carolina Marçon, MD, MSc, Allison J. Brown, MD, Miranda Rosenberg, MD, Lilia R.S. Guadanhim, MD, PhD, Doris Hexsel, MD   +13 more
doaj   +2 more sources

The Distinctive Evolution of orfX Clostridium parabotulinum Strains and Their Botulinum Neurotoxin Type A and F Gene Clusters Is Influenced by Environmental Factors and Gene Interactions via Mobile Genetic Elements

Frontiers in Microbiology, 2021
Of the seven currently known botulinum neurotoxin-producing species of Clostridium, C. parabotulinum, or C. botulinum Group I, is the species associated with the majority of human botulism cases worldwide.
Theresa J. Smith, Charles H. D. Williamson, Karen K. Hill, Shannon L. Johnson, Gary Xie, Fabrizio Anniballi, Bruna Auricchio, Rafael A. Fernández, Patricia A. Caballero, Paul Keim, Jason W. Sahl   +10 more
doaj   +1 more source

Botulinum Neurotoxin for the Treatment of Neuropathic Pain

Frontiers in Neurology, 2020
Botulinum neurotoxin is widely used for the treatment of central and peripherical neurological conditions. Initially used to treat strabismus, over the years its use has been expanded also to spasticity and other neurological disorders.
G. Egeo, L. Fofi, P. Barbanti
semanticscholar   +1 more source

Evolution of Three-Finger Toxin Genes in Neotropical Colubrine Snakes (Colubridae)

Toxins, 2023
Snake venom research has historically focused on front-fanged species (Viperidae and Elapidae), limiting our knowledge of venom evolution in rear-fanged snakes across their ecologically diverse phylogeny.
Kristy Srodawa, Peter A. Cerda, Alison R. Davis Rabosky, Jenna M. Crowe-Riddell   +3 more
doaj   +1 more source

Loss of AP-3 function affects spontaneous and evoked release at hippocampal mossy fiber synapses [PDF]

Proc Natl Acad Sci U S A (20/10/2006) sous presse, 2006
Synaptic vesicle (SV) exocytosis mediating neurotransmitter release occurs spontaneously at low intraterminal calcium concentrations and is stimulated by a rise in intracellular calcium. Exocytosis is compensated for by the reformation of vesicles at plasma membrane and endosomes.
arxiv   +1 more source

Exploring the genetic background of the botulism neurotoxin BoNT/B2 in Spain

Microbiology Spectrum, 2023
To determine whether the neurotoxin BoNT/B2 causing botulism in Spain is clonal, the genetic diversity and phylogenetic relationships of Clostridium botulinum from food-borne episodes and infant cases of the condition were explored.
Sylvia Valdezate, Gema Carrasco, María J. Medina, Noelia Garrido, Silvia del Pino, Monica Valiente, María P. Pallarés, Pilar Villalon   +7 more
doaj   +1 more source