Results 31 to 40 of about 65,558 (345)

Practice guideline update summary: Botulinum neurotoxin for the treatment of blepharospasm, cervical dystonia, adult spasticity, and headache

Neurology, 2016
Objective: To update the 2008 American Academy of Neurology (AAN) guidelines regarding botulinum neurotoxin for blepharospasm, cervical dystonia (CD), headache, and adult spasticity.
D. Simpson, M. Hallett, E. Ashman, C. Comella, Mark W. Green, G. Gronseth, M. Armstrong, D. Gloss, S. Potrebic, J. Jankovic, B. Karp, M. Naumann, Y. So, S. Yablon   +13 more
semanticscholar   +1 more source

Neuroprotective effects of Neurotrophin-3 in MPTP-induced zebrafish Parkinson’s disease model

Frontiers in Pharmacology, 2023
Introduction: Neurotrophin-3 (NT3) is a neuroprotective growth factor that induces the development, maintenance and survival of neurons. This study aims to localize NT3-expressing cells in the adult zebrafish brain and examine the role of NT3 in a ...
Noor Azzizah Omar, Noor Azzizah Omar, Jaya Kumar, Seong Lin Teoh   +3 more
doaj   +1 more source

Neuromuscular Weakness and Paralysis Produced by Snakebite Envenoming: Mechanisms and Proposed Standards for Clinical Assessment

Toxins, 2023
Respiratory and airway-protective muscle weakness caused by the blockade of neuromuscular transmission is a major cause of early mortality from snakebite envenoming (SBE).
Philip E. Bickler, Michael Abouyannis, Ashish Bhalla, Matthew R. Lewin   +3 more
doaj   +1 more source

BoNT/A in the Urinary Bladder—More to the Story than Silencing of Cholinergic Nerves

Toxins, 2022
Botulinum neurotoxin (BoNT/A) is an FDA and NICE approved second-line treatment for overactive bladder (OAB) in patients either not responsive or intolerant to anti-cholinergic drugs.
Hodan Ibrahim, Jacquie Maignel, Fraser Hornby, Donna Daly, Matthew Beard   +4 more
doaj   +1 more source

Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature

Toxins, 2017
Botulinum neurotoxins are diverse proteins. They are currently represented by at least seven serotypes and more than 40 subtypes. New clostridial strains that produce novel neurotoxin variants are being identified with increasing frequency, which ...
M. Peck, Theresa J. Smith, F. Anniballi, J. Austin, L. Bano, M. Bradshaw, Paula Cuervo, Luisa W Cheng, Y. Derman, B. Dorner, Audrey Fisher, K. Hill, Suzanne R. Kalb, H. Korkeala, M. Lindström, F. Lista, C. Lúquez, C. Mazuet, M. Pirazzini, M. Popoff, O. Rossetto, A. Rummel, D. Sesardic, Bal R Singh, S. Stringer   +24 more
semanticscholar   +1 more source

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

ASN Neuro, 2018
Parkinson disease (PD) is the second most common neurodegenerative movement disorder. Pharmacological animal models are invaluable tools to study the pathological mechanisms of PD.
Xiansi Zeng, Wenshuo Geng, Jinjing Jia
semanticscholar   +1 more source

Botulinum and Tetanus Neurotoxins [PDF]

Annual Review of Biochemistry, 2019
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic ...
Min Dong, Min Dong, Geoffrey Masuyer, Pål Stenmark   +3 more
openaire   +4 more sources

Distribution of Tetrodotoxin in the New Zealand Clam, Paphies australis, Established Using Immunohistochemistry and Liquid Chromatography-Tandem Quadrupole Mass Spectrometry

Toxins, 2018
Tetrodotoxin (TTX) is one of the most potent neurotoxins known. It was originally thought to only occur in puffer fish but has now been identified in twelve different classes of freshwater and marine organisms, including bivalves.
Laura Biessy, Kirsty F. Smith, Michael J. Boundy, Stephen C. Webb, Ian Hawes, Susanna A. Wood   +5 more
doaj   +1 more source

AbobotulinumtoxinA (Dysport®), OnabotulinumtoxinA (Botox®), and IncobotulinumtoxinA (Xeomin®) Neurotoxin Content and Potential Implications for Duration of Response in Patients

Toxins, 2018
Botulinum neurotoxin type-A (BoNT-A) blocks the release of acetylcholine from peripheral cholinergic nerve terminals and is an important option for the treatment of disorders characterised by excessive cholinergic neuronal activity.
Malgorzata Field, A. Splevins, P. Picaut, M. van der Schans, J. Langenberg, D. Noort, K. Foster   +6 more
semanticscholar   +1 more source

An Updated Review of Ciguatera Fish Poisoning: Clinical, Epidemiological, Environmental, and Public Health Management

Marine Drugs, 2017
Ciguatera Fish Poisoning (CFP) is the most frequently reported seafood-toxin illness in the world. It causes substantial human health, social, and economic impacts.
Melissa A. Friedman, Mercedes Fernandez, Lorraine C. Backer, Robert W. Dickey, Jeffrey Bernstein, Kathleen Schrank, Steven Kibler, Wendy Stephan, Matthew O. Gribble, Paul Bienfang, Robert E. Bowen, Stacey Degrasse, Harold A. Flores Quintana, Christopher R. Loeffler, Richard Weisman, Donna Blythe, Elisa Berdalet, Ram Ayyar, Danielle Clarkson-Townsend, Karen Swajian, Ronald Benner, Tom Brewer, Lora E. Fleming   +22 more
doaj   +1 more source