Results 41 to 50 of about 65,558 (345)

Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom

Science, 2018
How algae turn tides toxic Algal blooms can devastate marine mammal communities through the production of neurotoxins that accumulate within the food web. Brunson et al.
J. K. Brunson, J. K. Brunson, Shaun M. K. McKinnie, J. R. Chekan, J. McCrow, Z. Miles, Erin M. Bertrand, Erin M. Bertrand, Vincent A. Bielinski, H. Luhavaya, M. Oborník, G. Smith, D. Hutchins, A. Allen, A. Allen, B. Moore, B. Moore   +16 more
semanticscholar   +1 more source

Centrally mediated late motor recovery after botulinum toxin injection: Case reports and a review of current evidence

Journal of Rehabilitation Medicine, 2017
Objective: Botulinum neurotoxin is commonly utilized in neurorehabilitation as a treatment for focal spasticity. Clinical experience has yielded observations of late motor recovery after intramuscular injection of botulinum neurotoxin, that are not ...
Manuel F. Mas, Sheng Li, Gerard E. Francisco   +2 more
doaj   +1 more source

Overlooked Short Toxin-Like Proteins: A Shortcut to Drug Design

Toxins, 2017
Short stable peptides have huge potential for novel therapies and biosimilars. Cysteine-rich short proteins are characterized by multiple disulfide bridges in a compact structure.
Michal Linial, Nadav Rappoport, Dan Ofer
doaj   +1 more source

A neurotoxin that specifically targets Anopheles mosquitoes

Nature Communications, 2019
Clostridial neurotoxins, including tetanus and botulinum neurotoxins, generally target vertebrates. We show here that this family of toxins has a much broader host spectrum, by identifying PMP1, a clostridial-like neurotoxin that selectively targets ...
Estefanía Contreras, G. Masuyer, N. Qureshi, Swati Chawla, H. Dhillon, H. Lee, Jian-wu Chen, P. Stenmark, S. Gill   +8 more
semanticscholar   +1 more source

Critical appraisal on mitochondrial dysfunction in Alzheimer’s disease

AGING MEDICINE, Volume 5, Issue 4, Page 272-280, December 2022., 2022
Amyloid plaques deposit on neurons in case of Alzheimer's Disease. Mitochondria play a vital role in pathogenesis of Alzheimer's Disease. Mitochondrial dysfunction can lead to formation of mPTP, alteration of complexes 1,3 and 4, deficits in bioenergetics with impaired mitochondrial biogenesis. Abstract It is widely recognized that Alzheimer's disease (
Faizan Ahmad, Punya Sachdeva
wiley   +1 more source

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

Toxins, 2016
To date, several families of peptide toxins specifically interacting with ion channels in scorpion venom have been described. One of these families comprise peptide toxins (called KTxs), known to modulate potassium channels.
Caroline M. Cremonez, Mohitosh Maiti, Steve Peigneur, Juliana Silva Cassoli, Alexandre A. A. Dutra, Etienne Waelkens, Eveline Lescrinier, Piet Herdewijn, Maria Elena de Lima, Adriano M. C. Pimenta, Eliane C. Arantes, Jan Tytgat   +11 more
doaj   +1 more source

Horse immunization with short-chain consensus α-neurotoxin generates antibodies against broad spectrum of elapid venomous species

Nature Communications, 2019
Antivenoms are fundamental in the therapy for snakebites. In elapid venoms, there are toxins, e.g. short-chain α-neurotoxins, which are quite abundant, highly toxic, and consequently play a major role in envenomation processes.
Guillermo de la Rosa, F. Olvera, Irving G. Archundia, B. Lomonte, A. Alagón, G. Corzo   +5 more
semanticscholar   +1 more source

More than a Toxin: Protein Inventory of Clostridium tetani Toxoid Vaccines

Proteomes, 2019
Clostridium tetani is the etiological agent of tetanus, a life-threatening bacterial infection. The most efficient protection strategy against tetanus is a vaccination with the C.
Jens Möller, Max Edmund Kraner, Andreas Burkovski   +2 more
doaj   +1 more source

Current Perspectives on Reducing the β-ODAP Content and Improving Potential Agronomic Traits in Grass Pea (Lathyrus sativus L.)

Frontiers in Plant Science, 2021
Grass pea is well-established as one of the most resilient and versatile crops that can thrive under extreme climatic circumstances such as cold, heat, drought, salt-affected soils, submergence, and excessive rainfall along with resistance to several ...
Arpita Das, Ashok K. Parihar, Surendra Barpete, Shiv Kumar, Sanjeev Gupta   +4 more
doaj   +1 more source

Neurotoxin and Alpha-Neurotoxin Time-Resolved Absorption and Resonance FT-IR and Raman Bio spectroscopy and Density Functional Theory (DFT) Investigation of Vibrionic-Mode Coupling Structure in Vibrational Spectra Analysis

American Journal of Biomedical Science & Research, 2019
α-Neurotoxins are a group of neurotoxic peptides found in the venom of snakes in the families Elapidae and Hydrophiidae. They can cause paralysis, respiratory failure, and death.
A. Heidari, J. Esposito, Angela Caissutti   +2 more
semanticscholar   +1 more source