Results 61 to 70 of about 65,558 (345)

Comparative activity of dimethyl fumarate derivative IDMF in three models relevant to multiple sclerosis and psoriasis

FEBS Open Bio, EarlyView.
IDMF is a derivative of dimethyl fumarate (DMF) with a unique therapeutic potential at the intersection of psoriasis and multiple sclerosis. Here, we demonstrate that it compares favorably with DMF and its other derivatives, such as Diroximel, in the zebrafish, microglia, and lymphocyte models.
Yulin He, Guiyi Gong, Geovani Quijas, Simon Ming‐Yuen Lee, Ratan K. Chaudhuri, Krzysztof Bojanowski   +5 more
wiley   +1 more source

Climatic regulation of the neurotoxin domoic acid

Proceedings of the National Academy of Sciences of the United States of America, 2017
Significance We investigate regulation of domoic acid, a potent marine phycotoxin, at the climate scale. Due to the threat domoic acid can pose to public health, marine wildlife, and coastal economies, decades of laboratory experiments have examined ...
S. M. Mckibben, W. Peterson, A. Wood, V. Trainer, M. Hunter, Angelicque E. White   +5 more
semanticscholar   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Biodistribution and Lymphatic Tracking of the Main Neurotoxin of Micrurus fulvius Venom by Molecular Imaging

Toxins, 2016
The venom of the Eastern coral snake Micrurus fulvius can cause respiratory paralysis in the bitten patient, which is attributable to β-neurotoxins (β-NTx). The aim of this work was to study the biodistribution and lymphatic tracking by molecular imaging
Irene Vergara, Erick Y. Castillo, Mario E. Romero-Piña, Itzel Torres-Viquez, Dayanira Paniagua, Leslie V. Boyer, Alejandro Alagón, Luis Alberto Medina   +7 more
doaj   +1 more source

Eosinophil-derived neurotoxin enhances airway remodeling in eosinophilic chronic rhinosinusitis and correlates with disease severity

International Immunology, 2018
The role of eosinophil-derived neurotoxin in chronic ...
T. Tsuda, Yohei Maeda, Masayuki Nishide, S. Koyama, Yoshitomo Hayama, S. Nojima, H. Takamatsu, D. Okuzaki, Yuhei Kinehara, Y. Kato, T. Nakatani, S. Obata, H. Akazawa, Takashi Shikina, K. Takeda, M. Hayama, H. Inohara, A. Kumanogoh   +17 more
semanticscholar   +1 more source

Guanidinium Toxins and Their Interactions with Voltage-Gated Sodium Ion Channels

Marine Drugs, 2017
Guanidinium toxins, such as saxitoxin (STX), tetrodotoxin (TTX) and their analogs, are naturally occurring alkaloids with divergent evolutionary origins and biogeographical distribution, but which share the common chemical feature of guanidinium moieties.
Lorena M. Durán-Riveroll, Allan D. Cembella   +1 more
doaj   +1 more source

Recombinant botulinum neurotoxin serotype A1 in vivo characterization

Pharmacology Research & Perspectives, 2021
Clinically used botulinum neurotoxins (BoNTs) are natural products of Clostridium botulinum. A novel, recombinant BoNT type A1 (rBoNT/A1; IPN10260) has been synthesized using the native amino acid sequence expressed in Escherichia coli and has previously
Cindy Périer, Vincent Martin, Sylvie Cornet, Christine Favre‐Guilmard, Marie‐Noelle Rocher, Julien Bindler, Stéphanie Wagner, Emile Andriambeloson, Brian B. Rudkin, Rudy Marty, Alban Vignaud, Matthew Beard, Stephane Lezmi, Mikhail Kalinichev   +13 more
doaj   +1 more source

Botulinum neurotoxin formulations: overcoming the confusion

Clinical, Cosmetic and Investigational Dermatology, 2018
Botulinum toxin A is produced by anaerobic spore-forming bacteria and is used for various therapeutic and cosmetic purposes. Botulinum toxin A injections are the most popular nonsurgical procedure worldwide.
Souphiyeh Samizadeh, K. De Boulle
semanticscholar   +1 more source

An investigation into the feasibility and efficacy of stereotactic radiosurgery for 1–3 cm single brain lesions on the ring‐mounted Halcyon LINAC

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose An evaluation of the accuracy, safety, and efficiency of the Halcyon ring delivery system (RDS) for stereotactic radiosurgery (SRS) treatment to relatively small (1–3 cm) brain lesions. Methods After completing the extensive in‐house quality assurance checks including Winston–Lutz test and independent dose verification via MD Anderson ...
Kate Hazelwood, Shane McCarthy, Josh Misa, David Castelvetere, William St. Clair, Damodar Pokhrel   +5 more
wiley   +1 more source

Systemic adverse events after botulinum neurotoxin A injections in children with cerebral palsy

Developmental Medicine & Child Neurology, 2018
To identify factors that increase the likelihood of systemic adverse events after botulinum neurotoxin A (BoNT‐A) injections in children with cerebral palsy (CP).
S. Paget, Caitlyn M Swinney, Karen L. O. Burton, Karen Bau, S. O'Flaherty   +4 more
semanticscholar   +1 more source