Results 91 to 100 of about 53,418 (337)

The Anemonia viridis Venom: Coupling Biochemical Purification and RNA-Seq for Translational Research

Marine Drugs, 2018
Blue biotechnologies implement marine bio-resources for addressing practical concerns. The isolation of biologically active molecules from marine animals is one of the main ways this field develops.
Aldo Nicosia, Alexander Mikov, Matteo Cammarata, Paolo Colombo, Yaroslav Andreev, Sergey Kozlov, Angela Cuttitta   +6 more
doaj   +1 more source

Proximity to Industrial Releases of Toxins and Childhood Respiratory, Developmental, and Neurological Diseases: Environmental Ascription in East Baton Rouge Parish [PDF]

Recent research by Legot et al. (2010a, 2010b) has identified East Baton Rouge Parish (EBR) as a locus of particularly high volumes of emissions of developmental neurotoxins, i.e., those toxins that put children’s health and, especially, learning ...
Bruce London, Cristina Legot, John Shandra   +2 more
core  

RIG‐I Mediated Neuron‐Specific IFN Type 1 Signaling in FUS‐ALS Induces Neurodegeneration and Offers New Biomarker‐Driven Individualized Treatment Options for (FUS‐)ALS

Advanced Science, EarlyView.
Using iPSC‐derived motoneurons and postmortem tissue from FUS‐ALS patients, it is demonstrated that increased mitochondrial transcription leads to elevated cytosolic double‐stranded RNA (dsRNA) levels. This aberrant accumulation activates a RIG‐I–dependent innate immune response leading to neurodegeneration, which is amenable for FDA‐ and EMA‐approved ...
Marcel Naumann, Theresa M. Wierschin, Stefanie Kretschmer, Banaja P. Dash, Aaron Held, Andrea Salzinger, Kevin Peikert, Anže Karlek, Hannes Glaß, Dajana Großmann, René Günther, Susanne Petri, Annekathrin Rödiger, David Brenner, Francisco Pan‐Montojo, Eleonora Aronica, Markus Kipp, Vitaly Zimyanin, Jared Sterneckert, Torsten Grehl, Noah D. Seebacher, Tobias M. Böckers, Alberto Catanese, Brian J. Wainger, Patrick Oeckl, Min Ae Lee‐Kirsch, Andreas Hermann   +26 more
wiley   +1 more source

Haemorrhagic, proteolytic and neurotoxic activities produced by Duvernoy”™s gland secretion from the false coral snake (Erythrolamprus bizona Jan 1863) (Serpentes: Colubridae)

Revista Científica, 2010
Many colubrid snakes produce toxic oral secretions. Venom (Duvernoy´s gland secretion) collected from Venezuelan species of opisthoglyphous (rear-fanged) colubrid snakes has been studied.
Karel Lemoine, Alexis Rodríguez Acosta
doaj  

Properties and Pharmacology of Scorpion Toxins and Their Biotechnological Potential in Agriculture and Medicine

Toxins
Scorpion venoms contain a wide range of toxins that interact with a variety of target molecules (ion channels, receptors and enzymes) associated with synaptic transmission, action potential propagation, cardiac function, hemostasis and other ...
Cháriston André Dal Belo, Stephen Hyslop, Célia Regina Carlini   +2 more
doaj   +1 more source

The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study [PDF]

, 2010
The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat ...
Eweka, A, Eweka, AO
core   +1 more source

Genome‐Wide by Lifetime Environment Interaction Studies of Brain Imaging Phenotypes

Advanced Science, EarlyView.
This study explores genome‐wide by lifetime environment interactions on brain imaging phenotypes. Gene‐environment interactions explain more phenotypic variance than main effects, pinpoint regulatory variants, and reveal exposure‐specific biological pathways.
Sijia Wang, Meiyun Wang, Peng Zhang, Jingliang Cheng, Longjiang Zhang, Wenzhen Zhu, Shijun Qiu, Zuojun Geng, Guangbin Cui, Yongqiang Yu, Weihua Liao, Xi‐Nian Zuo, Hui Zhang, Bo Gao, Xiaojun Xu, Tong Han, Zhenwei Yao, Quan Zhang, Feng Liu, Qiang Xu, Jiayuan Xu, Jilian Fu, Nana Liu, Yuan Ji, Jie Tang, Lining Guo, Mengge Liu, Xiaoxiao Xiao, Xiaoxuan Liu, Wei Li, Caihong Wang, Wei Wei, Dapeng Shi, Su Lui, Zhihan Yan, Feng Chen, Jing Zhang, Wen Shen, Yanwei Miao, Dawei Wang, Jia‐Hong Gao, Yunjun Yang, Kai Xu, Junfang Xian, Bing Zhang, Xiaochu Zhang, Zhaoxiang Ye, Le Yu, Wen Qin, Meng Liang, Chunshui Yu, the CHIMGEN Consortium   +51 more
wiley   +1 more source

Outbreak of botulism in horses associated with toxin A and D in São Paulo state, Brazil

Pesquisa Veterinária Brasileira
: Botulism is a neuromuscular disorder caused by neurotoxins produced by Clostridium botulinum. Equine botulism has been frequently reported worldwide; however, descriptions of cases in South America remain uncommon.
Simone Miyashiro, Amanda C. Valim, Neimar N. Roncati, Nicole F. Paretsis, Alessandra C. Nassar, Fabrício M. Cerri, Danilo G.A. Andrade, José P. Oliveira-Filho, Rogério M. Amorim, Alexandre S. Borges   +9 more
doaj   +1 more source

Challenging the Clostridium botulinum toxin type A (BoNT/A) with a selection of microorganisms by culture methods and extended storage of used vials to assess the loss of sterility [PDF]

, 2015
In 2002, botulinum toxin type A (BoNT/A) was approved by the US Food and Drug Administration (FDA) for cosmetic use. However, there may be procedural differences between the ways in which a clinician handles, applies and stores the product compared to ...
Crean, Stjohn, Dennison, Sarah Rachel, Morton, Leslie Hugh Glyn, Singhrao, Simarjit Kaur, Turner, Martin   +4 more
core  

Clostridium botulinum Type E Toxins Bind to Caco-2 Cells by a Different Mechanism from That of Type A Toxins [PDF]

, 2012
Cultured Clostridium botulinum strains produce progenitor toxins designated as 12S, 16S, and 19S toxins. The 12S toxin consists of a neurotoxin (NTX, 7S) and a non-toxic non-hemagglutinin (NTNH).
Ma, Shaobo, Nengah Dwi Fatmawati, Ni, Oguma, Keiji, Suzuki, Tomonori, Yamamoto, Yumiko, Yokota, Kenji, Zhang, Kai   +6 more
core   +1 more source