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Mechanisms of Neurotransmitter Release
International Review of Neurobiology, 1999Publisher Summary This chapter focuses on the mechanism of neurotransmitter release. The primary form of intercellular communication within the nervous system is mediated by chemical transmission at synapses. Upon propagation of an action potential into the nerve terminal, there is an influx of Ca2+ through voltage-activated Ca2+ channels, which ...
J T, Littleton, L, Pallanck, B, Ganetzky
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2008
Neurons send out a multitude of chemical signals, called neurotransmitters, to communicate between neurons in brain, and between neurons and target cells in the periphery. The most important of these communication processes is synaptic transmission, which accounts for the ability of the brain to rapidly process information, and which is characterized ...
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Neurons send out a multitude of chemical signals, called neurotransmitters, to communicate between neurons in brain, and between neurons and target cells in the periphery. The most important of these communication processes is synaptic transmission, which accounts for the ability of the brain to rapidly process information, and which is characterized ...
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UNC-13 and neurotransmitter release
Nature Neuroscience, 1999Genetic studies in mice, worms and flies indicate that the synaptic protein UNC-13 plays a central role in the regulation of vesicle fusion.
H, Tokumaru, G J, Augustine
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Uptake and Release of Neurotransmitters
Current Protocols in Neuroscience, 1998AbstractThe availability of clonal cell lines for norepinephrine, dopamine, and serotonin transporters allows the characterization of drug interactions with transporter recognition sites using radioligands, as well as the characterization of drug effects on selective transporter‐mediated uptake and release of substrate. In addition to clonal cell lines,
A, Janowsky, K, Neve, A J, Eshleman
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Cytoskeleton dynamics during neurotransmitter release
Trends in Neurosciences, 1993It has become apparent in recent years that the cytoskeleton and its associated proteins play a major role in secretion. This review summarizes recent findings on the cytoskeleton organization and the molecular topology of its regulatory proteins, as well as the dynamic changes that occur in this organelle during secretion from neurons and secretory ...
J M, Trifaró, M L, Vitale
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Synaptotagmins: Beyond Presynaptic Neurotransmitter Release
The Neuroscientist, 2019Synaptotagmins (Syts) are well-established primary Ca2+ sensors to initiate presynaptic neurotransmitter release. They also play critical roles in the docking, priming, and fusion steps of exocytosis, as well as the tightly coupled exo-endocytosis, in presynapses.
Xuanang Wu +3 more
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Airway nerves: neurotransmitter release
Current Opinion in Pharmacology, 2002A number of methods exist that allow one to study the pharmacology of neuropeptide release in the airways. Methods include in vitro organ bath techniques to measure neuropeptide release functionally as changes in smooth-muscle tone and direct measurement of neuropeptide release from airway tissue or cultured sensory neurones. The measurement of sensory
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Neurotransmitter release at rapid synapses
Biochimie, 2000The classical concept of the vesicular hypothesis for acetylcholine (ACh) release, one quantum resulting from exocytosis of one vesicle, is becoming more complicated than initially thought. 1) synaptic vesicles do contain ACh, but the cytoplasmic pool of ACh is the first to be used and renewed on stimulation.
Y, Dunant, M, Israël
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1999
Abstract Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons that communicate with each other and their ...
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Abstract Understanding the mechanisms that underlie brain activity and function remains one of the major frontiers of biology. All the processes of how we co-ordinate our movements, sense our surroundings, react to stimuli and learn and retain information rely on complicated networks of neurons that communicate with each other and their ...
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Talking back: dendritic neurotransmitter release
Trends in Neurosciences, 2003Classical transmitters and neuropeptides can be released from the dendrites of many neuronal populations, to act as retrograde signals that modulate synaptic transmission, electrical activity and, in some cases, morphology of the cell of origin. For the hypothalamic neuroendocrine cells that release vasopressin and oxytocin, the stimuli, mechanisms and
Mike, Ludwig, Quentin J, Pittman
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