Results 11 to 20 of about 12,820,523 (360)

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

Neural Regeneration Research, 2017
Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has
Tuane Bazanella Sampaio, Anne Suely Savall, Maria Eduarda Ziani Gutierrez, Simone Pinton   +3 more
doaj   +2 more sources

Neurotrophic factors and their effects in the treatment of multiple sclerosis

Advanced Biomedical Research, 2015
Neurotrophins are small molecules of polypeptides, which include nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor (GDNF) family ligands, and neuropoietic cytokines. These factors have an important role in neural regeneration,
Shahnaz Razavi, Ghasemi Nazem, Mohammad Mardani, Ebrahim Esfandiari, Hossein Salehi, Sayyed Hamid Zarkesh Esfahani   +5 more
doaj   +2 more sources

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research

Neural Plasticity, 2022
Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe.
Serena-Kaye Sims, Brynna Wilken-Resman, Crystal J. Smith, Ashley Mitchell, Lilly McGonegal, Catrina Sims-Robinson   +5 more
doaj   +2 more sources

Peripheral blood neurotrophic factor levels in children with autism spectrum disorder: a meta-analysis

Scientific Reports, 2021
Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD).
Shu-Han Liu, Xiao-Jie Shi, Fang-Cheng Fan, Yong Cheng   +3 more
doaj   +2 more sources

Sustained delivery of neurotrophic factors to treat spinal cord injury

Translational Neuroscience, 2021
Acute spinal cord injury (SCI) is a devastating condition that results in tremendous physical and psychological harm and a series of socioeconomic problems.
Aikeremujiang Muheremu, Li Shu, Jing Liang, Abudunaibi Aili, Kan Jiang   +4 more
semanticscholar   +1 more source

Engineering Silk Fibroin‐Based Nerve Conduit with Neurotrophic Factors for Proximal Protection after Peripheral Nerve Injury

Advanced Healthcare Materials, 2020
Artificial nerve conduits capable of adequately releasing neurotrophic factors are extensively studied to bridge nerve defects. However, the lack of neurotrophic factors in the proximal area and their visible effects in axonal retrograde transport ...
Cristiana R. Carvalho, Wei Chang, J. Silva-Correia, R. Reis, J. Oliveira, J. Kohn   +5 more
semanticscholar   +1 more source

Advances in treatment of neurodegenerative diseases: Perspectives for combination of stem cells with neurotrophic factors.

World Journal of Stem Cells, 2020
Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease and amyotrophic lateral sclerosis, are a group of incurable neurological disorders, characterized by the chronic progressive loss of different neuronal ...
Jie Wang, Weiwei Hu, Zhi Jiang, Meijiang Feng   +3 more
semanticscholar   +1 more source

Antidepressant-like effects of trophic factor receptor signaling

Frontiers in Molecular Neuroscience, 2022
A significant body of research has demonstrated that antidepressants regulate neurotrophic factors and that neurotrophins themselves are capable of independently producing antidepressant-like effects.
Monica Sathyanesan, Monica Sathyanesan, Samuel S. Newton, Samuel S. Newton   +3 more
doaj   +1 more source

Gene expression profiles of reactive astrocytes cultured from dopamine-depleted striatum

Neurobiology of Disease, 2005
We have carried out cDNA array analysis in order to characterize the gene expression profiles of reactive astrocytes from dopamine-depleted striatum.
Takao Nakagawa, Takeshi Yabe, Joan P. Schwartz   +2 more
doaj   +1 more source

Modulation of neurotrophic signaling pathways by polyphenols [PDF]

, 2015
Polyphenols are an important class of phytochemicals, and several lines of evidence have demonstrated their beneficial effects in the context of a number of pathologies including neurodegenerative disorders such as Alzheimer's and Parkinson's disease. In
Firuzi, Omidreza, Hosseini, Razieh, Moosavi, Fatemeh, Saso, Luciano   +3 more
core   +1 more source