Results 11 to 20 of about 12,451,033 (373)

Neurotrophic factors in Alzheimer's and Parkinson's diseases: implications for pathogenesis and therapy

open access: yesNeural Regeneration Research, 2017
Neurotrophic factors comprise essential secreted proteins that have several functions in neural and non-neural tissues, mediating the development, survival and maintenance of peripheral and central nervous system. Therefore, neurotrophic factor issue has
Tuane Bazanella Sampaio   +3 more
doaj   +2 more sources

Neurotrophic factors and corneal nerve regeneration

open access: yesNeural Regeneration Research, 2017
The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination.
Marta Sacchetti, Alessandro Lambiase
doaj   +2 more sources

Neurotrophic factors and their effects in the treatment of multiple sclerosis

open access: yesAdvanced Biomedical Research, 2015
Neurotrophins are small molecules of polypeptides, which include nerve growth factor (NGF) family, glial cell line-derived neurotrophic factor (GDNF) family ligands, and neuropoietic cytokines. These factors have an important role in neural regeneration,
Shahnaz Razavi   +5 more
doaj   +2 more sources

Brain-Derived Neurotrophic Factor and Nerve Growth Factor Therapeutics for Brain Injury: The Current Translational Challenges in Preclinical and Clinical Research

open access: yesNeural Plasticity, 2022
Ischemic stroke and traumatic brain injury (TBI) are among the leading causes of death and disability worldwide with impairments ranging from mild to severe.
Serena-Kaye Sims   +5 more
doaj   +2 more sources

Engineering Silk Fibroin‐Based Nerve Conduit with Neurotrophic Factors for Proximal Protection after Peripheral Nerve Injury

open access: yesAdvanced Healthcare Materials, 2020
Artificial nerve conduits capable of adequately releasing neurotrophic factors are extensively studied to bridge nerve defects. However, the lack of neurotrophic factors in the proximal area and their visible effects in axonal retrograde transport ...
Cristiana R. Carvalho   +5 more
semanticscholar   +1 more source

Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells. [PDF]

open access: yesPLoS ONE, 2011
Recent studies have indicated that the choice of lineage of neural progenitor cells is determined, at least in part, by environmental factors, such as neurotrophic factors.
Masaya Nakamura   +4 more
doaj   +1 more source

The Role of BDNF on Neural Plasticity in Depression

open access: yesFrontiers in Cellular Neuroscience, 2020
Using behavioral, pharmacological, and molecular methods, lots of studies reveal that depression is closely related to the abnormal neural plasticity processes occurring in the prefrontal cortex and limbic system such as the hippocampus and amygdala ...
Tao Yang   +7 more
doaj   +1 more source

MANF: A New Player in the Control of Energy Homeostasis, and Beyond

open access: yesFrontiers in Physiology, 2018
All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and ...
Su Yang, Shihua Li, Xiao-Jiang Li
doaj   +1 more source

Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease

open access: yesLife, 2023
The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested.
Tadahiro Numakawa, Ryutaro Kajihara
doaj   +1 more source

Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression

open access: yesPsychopharmacology, 2018
Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired functioning of cortico-limbic regions involved in mood and emotion regulation.
M. Levy   +5 more
semanticscholar   +1 more source

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