Results 21 to 30 of about 12,815,513 (320)
Frontiers in Physiology, 2019 Astrocytes, oligodendrocytes, and microglia are abundant cell types found in the central nervous system and have been shown to play crucial roles in regulating both normal and disease states.
Suvi Pöyhönen +3 more
semanticscholar +1 more source
Brain-derived neurotrophic factor in Alzheimer’s disease and its pharmaceutical potential
Translational Neurodegeneration, 2022 Synaptic abnormalities are a cardinal feature of Alzheimer’s disease (AD) that are known to arise as the disease progresses. A growing body of evidence suggests that pathological alterations to neuronal circuits and synapses may provide a mechanistic ...
Li Gao +3 more
semanticscholar +1 more source
Materials & Design, 2022 The combination of biological scaffold and neural stem cells (NSCs) is a promising treatment strategy for spinal cord injury (SCI). But adverse niche at injures spinal cord severe hamper the transplanted NSCs to preferentially differentiate neurons.
Shuo Liu +5 more
doaj +1 more source
Neurotrophic factors and neuroplasticity pathways in the pathophysiology and treatment of depression
Psychopharmacology, 2018 Depression is a major health problem with a high prevalence and a heavy socioeconomic burden in western societies. It is associated with atrophy and impaired functioning of cortico-limbic regions involved in mood and emotion regulation.
M. Levy +5 more
semanticscholar +1 more source
Neurotrophins and Other Growth Factors in the Pathogenesis of Alzheimer’s Disease
Life, 2023 The involvement of the changed expression/function of neurotrophic factors in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), has been suggested.
Tadahiro Numakawa, Ryutaro Kajihara
doaj +1 more source
Neuronal plasticity and neurotrophic factors in drug responses
Molecular Psychiatry, 2017 Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other members of the neurotrophin family, are central mediators of the activity-dependent plasticity through which environmental experiences, such as sensory information are ...
E. Castrén, H. Antila
semanticscholar +1 more source
Scientific Reports, 2021 Increasing evidence suggests that abnormal regulation of neurotrophic factors is involved in the etiology and pathogenesis of Autism Spectrum Disorder (ASD).
Shu-Han Liu +3 more
doaj +1 more source
Neurotrophic factor-based pharmacological approaches in neurological disorders
Neural Regeneration Research, 2023 Aging is a physiological event dependent on multiple pathways that are linked to lifespan and processes leading to cognitive decline. This process represents the major risk factor for aging-related diseases such as Alzheimer’s disease, Parkinson’s ...
Margherita Alfonsetti +2 more
doaj +1 more source
Neurotrophic factors in tension-type headache
Arquivos de Neuro-Psiquiatria, 2015 Neurotrophic factors (NF) are involved in pain regulation and a few studies have suggested that they may play a pathophysiological role in primary headaches. The aim of this study was to investigate NF levels in patients with tension type headache (TTH).
Renan B. Domingues +3 more
doaj +1 more source
Neural Regeneration Research, 2022 [INLINE:1] The introduction of neurotrophic factors into injured peripheral nerve sites is beneficial to peripheral nerve regeneration. However, neurotrophic factors are rapidly degraded in vivo and obstruct axonal regeneration when used at a ...
Ci Li +7 more
doaj +1 more source