Results 151 to 160 of about 91,612,173 (178)

Dopamine transporter trafficking is regulated by neutral sphingomyelinase 2/ceramide kinase

Cellular Signalling, 2018
Dopamine (DA) reuptake is the primary mechanism to terminate dopaminergic transmission in the synaptic cleft. The dopamine transporter (DAT) has an important role in the regulation of DA reuptake. This study provides anatomical and physiological evidence that DAT recycling is regulated by ceramide kinase via the sphingomyelin pathway.
Jong Hoon, Won, Seok Kyun, Kim, In Chul, Shin, Hae Chan, Ha, Ji Min, Jang, Moon Jung, Back, Dae Kyong, Kim   +6 more
openaire   +2 more sources

The neutral sphingomyelinase-2 is involved in angiogenic signaling triggered by oxidized LDL

Free Radical Biology and Medicine, 2016
Capillaries of the external part of the normal arterial wall constitute the vasa vasorum network. In atherosclerotic lesions, neovascularization occurs in areas of intimal hyperplasia where it may promote plaque expansion, and intraplaque hemorrhage. Oxidized LDL that are present in atherosclerotic areas activate various angiogenic signaling pathways ...
Camare, Caroline, Augé, Nathalie, Pucelle, Mélanie, Saint-Lebes, Bertrand, Grazide, Marie-Hélène, Nègre-Salvayre, Anne, Salvayre, Robert   +6 more
openaire   +2 more sources

Crystal structure and activation mechanism of human neutral sphingomyelinase 2

The FASEB Journal, 2017
Neutral sphingomyelinase 2 (nSMase2) is a magnesium‐dependent phophodiesterase that generates the bioactive sphingolipid ceramide. Ceramide is a critically important secondary messenger that acts in a variety of cellular pathways such as apoptosis, inflammation, cell growth and differentiation.
Prajna Shanbhogue, Michael Airola, Achraf Shamseddine, Kip Guja, Rohan Maini, Nana Bartke, Bill Wu, Lina Obeid, Miguel Garcia‐Diaz, Yusuf Hannun   +9 more
openaire   +1 more source

Neutral sphingomyelinase 2 induces dopamine uptake through regulation of intracellular calcium

Cellular Signalling, 2010
Ceramide serves as a second messenger produced from sphingomyelin by the activation of sphingomyelinase (SMase). Here, we suggest that neutral SMase 2 (nSMase2) may regulate dopamine (DA) uptake. nSMase2 siRNA-transfected PC12 cells showed lower levels of nSMase activity and ceramide than scramble siRNA-transfected and control cells.
Seok Kyun, Kim, Kyong Hoon, Ahn, Jung Eun, Ji, Jong Min, Choi, Hyung Jun, Jeon, Sung Yun, Jung, Kwang Mook, Jung, Dae Kyong, Kim   +7 more
openaire   +2 more sources

A CRITICAL ROLE FOR NEUTRAL SPHINGOMYELINASE-2 IN DOXORUBICIN-INDUCED CARDIOTOXICITY

ABSTRACT Cardiotoxicity is a major side effect of Doxorubicin (Dox) that has hampered its clinical utility, and strategies to mitigate this cardiotoxicity are limited. Sphingolipids (SL) are central to the chemotherapy response in cancer but their role in normal tissue is less clear.
Samia Mohammed, Victoria Franzi, Ya-Ping Jiang, Fabiola N. Velazquez, Monica E. Alexander, Folnetti A. Alvarez, Danielle Lambadis, Sam B. Chiappone, Anne G. Ostermeyer-Fay, Leiqing Zhang, Achraf A. Shamseddine, Daniel Canals, Ashley J. Snider, Richard Z. Lin, Yusuf A. Hannun, Christopher J. Clarke   +15 more
openaire   +2 more sources

Regulation and function of neutral sphingomyelinase 2

2023
Samia Mohammed, Jihui Ren, Botheina Ghandour, Christopher J. Clarke, Yusuf A. Hannun   +4 more
openaire   +1 more source

Neutral Sphingomyelinase-2 Restrains TAZ to Suppress Breast Tumor Growth

ABSTRACT Loss of tumor suppressor gene (TSG) activity is pervasive across cancers and linked to worse clinical outcomes, yet therapeutic efforts aimed at restoring TSGs have remained elusive. One underexplored avenue to address this problem is the targeting of metabolic signaling pathways that actively enforce tumor suppressive programs.
Andrew E. Resnick, Victoria Franzi, Botheina K. Ghandour, Sam B. Chiappone, Sebastien Lalanne, Monica E. Alexander, Deanna M. Peperno, Jowana Obeid, Ishmam Pritam, Ian D. Miranda, Nicolas Coant, Michael V. Airola, Mehdi Damaghi, Fabiola N. Velazquez, Yusuf A. Hannun, Christopher J. Clarke   +15 more
openaire   +1 more source

Neutral Magnesium-Dependent Sphingomyelinase from Liver Plasma Membrane: Purification and Inhibition by Ubiquinol

Journal of Bioenergetics and Biomembranes, 2001
José Manuel Villalba, Placido Navas
exaly  

SMALL MOLECULE NEUTRAL SPHINGOMYELINASE 2 (nSMase2) INHIBITORS

2020
TSUKAMOTO TAKASHI, HIN NIYADA, STEPANEK ONDREJ, SLUSHER BARABRA, ROJAS CAMILO, THOMAS AJIT G   +5 more
openaire   +3 more sources

American Journal of Respiratory Cell and Molecular Biology

American Journal of Respiratory Cell and Molecular Biology, 2015
Simon Vu, Samuel Chung, Simone Filosto
exaly