Results 131 to 140 of about 91,612,173 (178)

Neutral Sphingomyelinase 2 Heightens Anti-Melanoma Immune Responses and Anti-PD-1 Therapy Efficacy. [PDF]

Cancer Immunol Res, 2021
Montfort A, Bertrand F, Rochotte J, Gilhodes J, Filleron T, Milhès J, Dufau C, Imbert C, Riond J, Tosolini M, Clarke CJ, Dufour F, Constantinescu AA, Junior NF, Garcia V, Record M, Cordelier P, Brousset P, Rochaix P, Silvente-Poirot S, Therville N, Andrieu-Abadie N, Levade T, Hannun YA, Benoist H, Meyer N, Micheau O, Colacios C, Ségui B.   +28 more
europepmc   +1 more source

Glycolytic Enzyme HK2 Phosphorylates nSMase1 to Promote Astrocytic Exosomes Biogenesis Contributing to Acute Ischemic Stroke Injury

Advanced Science
Stroke represents a significant threat to public health, with insufficient understanding of its pathological mechanisms hindering therapeutic advancements. Exosomes are implicated in both the injury and recovery processes of ischemic stroke.
Chen Chen, YuWei Zhou, LongXiang Sheng, FangYing Mai, YuXuan Ding, ShiRan Hong, JiaXin Wu, JiaKai Pi, GuangMei Yan, YiJun Huang, JingJing Duan, Xuefeng Hua, Wei Yin   +12 more
doaj   +1 more source

Inhibition of neutral sphingomyelinase 2 reduces extracellular vesicle release from neurons, oligodendrocytes, and activated microglial cells following acute brain injury. [PDF]

Biochem Pharmacol, 2021
Tallon C, Picciolini S, Yoo SW, Thomas AG, Pal A, Alt J, Carlomagno C, Gualerzi A, Rais R, Haughey NJ, Bedoni M, Slusher BS.   +11 more
europepmc   +1 more source

Development of a FRET-Based Assay for Human Neutral Sphingomyelinase 2. [PDF]

Biochemistry
Aywa KM, Kappe C, Ghandour B, Gao S, Arenz C, Hannun YA, Airola MV.   +6 more
europepmc   +1 more source

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α. [PDF]

Sci Rep, 2020
Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R.   +8 more
europepmc   +1 more source

The regulation of lipid metabolism in T cells by neutral sphingomyelinase-2 (NSM2)

Accumulation of lipid droplets (LD) and ceramides (Cer) is associated with the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD) a condition frequently co-occurring with type 2 diabetes and diminished immune functionality.
openaire   +2 more sources

Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide. [PDF]

Am J Cancer Res
Shams SG, Dawud D, Michalak K, Makhlouf MM, Moustafa A, Jazwinski SM, Kang L, Zerfaoui M, El Sayed KA, Abd Elmageed ZY.   +9 more
europepmc   +1 more source

Mechanisms of apoptosis induced by etoposide (VP-16),a DNA-damaging agent, in glioma cells 1) Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells 2) Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells 3) p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells

博士論文 (Doctoral dissertation)1) Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells2) Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in ...
澤田, 元史
core  

The juxtamembrane linker in neutral sphingomyelinase-2 functions as an intramolecular allosteric switch that activates the enzyme. [PDF]

J Biol Chem, 2019
Shanbhogue P, Hoffmann RM, Airola MV, Maini R, Hamelin DJ, Garcia-Diaz M, Burke JE, Hannun YA.   +7 more
europepmc   +1 more source

Neutral sphingomyelinase 2 inhibitors based on the 4-(1H-imidazol-2-yl)-2,6-dialkoxyphenol scaffold. [PDF]

Eur J Med Chem, 2019
Stepanek O, Hin N, Thomas AG, Dash RP, Alt J, Rais R, Rojas C, Slusher BS, Tsukamoto T.   +8 more
europepmc   +1 more source