Results 121 to 130 of about 91,612,173 (178)

Neutral Sphingomyelinase 2 Mediates Oxidative Stress Effects on Astrocyte Senescence and Synaptic Plasticity Transcripts. [PDF]

Mol Neurobiol, 2022
Zhu Z, Quadri Z, Crivelli SM, Elsherbini A, Zhang L, Tripathi P, Qin H, Roush E, Spassieva SD, Nikolova-Karakashian M, McClintock TS, Bieberich E.   +11 more
europepmc   +1 more source

Mechanisms of apoptosis induced by etoposide (VP-16),a DNA-damaging agent, in glioma cells 1) Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells 2) Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in glioma cells 3) p53 regulates ceramide formation by neutral sphingomyelinase through reactive oxygen species in human glioma cells [PDF]

, 2001
博士論文 (Doctoral dissertation)1) Ordering of ceramide formation, caspase activation, and Bax/Bcl-2 expression during etoposide-induced apoptosis in C6 glioma cells2) Influence of Bax or Bcl-2 overexpression on the ceramide-dependent apoptotic pathway in ...
397133, 澤田, 元史
core  

SMPD3 suppresses oligodendroglioma growth via dual autocrine-paracrine roles

Communications Biology
Oligodendrogliomas (ODGs) are slow-growing tumors with poorly defined biology. Here, we identify SMPD3, encoding neutral sphingomyelinase 2 (nSMase2), as a negative regulator of ODG progression via extracellular vesicle (EV) biogenesis and autocrine ...
Fermisk Saleh, Anjali Balakrishnan, Lata Adnani, Shiekh Tanveer Ahmad, Vorapin Chinchalongporn, Ahmed El-Sehemy, Thomas Olender, Myra J. Chen, Aditya Kshirsagar, Andrew Kennedy, Nilakshi Kulathunga, Oleksandr Prokopchuk, Lakshmy Vasan, Yacine Touahri, Rehnuma Islam, Sajeevan Sujanthan, Dawn Zinyk, Lacrimioara C. Comanita, Boris Kan, Taylor Fleming, Iacovos P. Michael, Cindi M. Morshead, Hon S. Leong, Satoshi Okawa, Marjorie Brand, Valerie A. Wallace, Jennifer A. Chan, Carol Schuurmans   +27 more
doaj   +1 more source

Neutral Sphingomyelinase 2 Is Palmitoylated on Multiple Cysteine Residues [PDF]

Journal of Biological Chemistry, 2007
Motohiro Tani, Yusuf A. Hannun
openaire   +1 more source

Sindbis Virus Entry into Cells Triggers Apoptosis by Activating Sphingomyelinase, Leading to the Release of Ceramide

, 2000
Sindbis virus (SV) causes acute encephalomyelitis by infecting and inducing the death of neurons. Induction of apoptosis occurs during virus entry and involves acid-induced conformational changes in the viral surface glycoproteins and sphingomyelin (SM ...
Jia-Tsrong Jan, Subroto Chatterjee, Diane E. Griffin   +2 more
core   +1 more source

Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. [PDF]

Int J Mol Sci, 2023
Pavlic A, Poelman H, Wasilewski G, Wichapong K, Lux P, Maassen C, Lutgens E, Schurgers LJ, Reutelingsperger CP, Nicolaes GAF.   +9 more
europepmc   +1 more source

Unconventional Secretion of Angiogenic Sonic Hedgehog–Containing Extra‐Large Extracellular Vesicles is Driven by PI3K–Rab18‐GDP Signalling

Journal of Extracellular Biology
Extra‐large extracellular vesicles (XLEVs), with diameters > 600 nm, are increasingly recognised as mediators of specialized modes of intercellular communication; however, the molecular mechanisms governing their biogenesis and functional regulation ...
Shuo Wang, Rio Imai, Yuya Kaneko, Yosuke Tanaka   +3 more
doaj   +1 more source

Allosteric Inhibition of Neutral Sphingomyelinase 2 (nSMase2) by DPTIP: From Antiflaviviral Activity to Deciphering Its Binding Site through In Silico Studies and Experimental Validation. [PDF]

Int J Mol Sci, 2022
Álvarez-Fernández H, Mingo-Casas P, Blázquez AB, Caridi F, Saiz JC, Pérez-Pérez MJ, Martín-Acebes MA, Priego EM.   +7 more
europepmc   +1 more source

Secretion and transfer of adipose lipoprotein lipase utilizes neutral sphingomyelinase 2 generated exosomes

ABSTRACT Lipoprotein lipase (LPL) is critical for clearance of circulating triglycerides and for tissue fatty acid supply. LPL is primarily synthesized and secreted by adipocytes into the interstitium and must traffic from there to the abluminal/basolateral side of capillary endothelial cells.
Terri A. Pietka, Edward F. Morris, Megan Basco, Jennifer Shew, Ni-huiping Son, Zhenxiu Liu, Brandon A. Davies, Ira J. Goldberg, Clair Crewe, Nada A. Abumrad   +9 more
openaire   +2 more sources

Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides. [PDF]

Cell Mol Life Sci, 2021
Zietzer A, Jahnel AL, Bulic M, Gutbrod K, Düsing P, Hosen MR, Dörmann P, Werner N, Nickenig G, Jansen F.   +9 more
europepmc   +1 more source