Results 141 to 150 of about 91,612,173 (178)

Activation of neutral sphingomyelinase 2 by starvation induces cell-protective autophagy via an increase in Golgi-localized ceramide. [PDF]

Cell Death Dis, 2018
Back MJ, Ha HC, Fu Z, Choi JM, Piao Y, Won JH, Jang JM, Shin IC, Kim DK.   +8 more
europepmc   +1 more source

Enriched Expression of Neutral Sphingomyelinase 2 in the Striatum is Essential for Regulation of Lipid Raft Content and Motor Coordination. [PDF]

Mol Neurobiol, 2018
Tan LH, Tan AJ, Ng YY, Chua JJ, Chew WS, Muralidharan S, Torta F, Dutta B, Sze SK, Herr DR, Ong WY.   +10 more
europepmc   +1 more source

DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation. [PDF]

Sci Rep, 2018
Rojas C, Barnaeva E, Thomas AG, Hu X, Southall N, Marugan J, Chaudhuri AD, Yoo SW, Hin N, Stepanek O, Wu Y, Zimmermann SC, Gadiano AG, Tsukamoto T, Rais R, Haughey N, Ferrer M, Slusher BS.   +17 more
europepmc   +1 more source

Neutral Sphingomyelinase-2 Deficiency Ameliorates Alzheimer's Disease Pathology and Improves Cognition in the 5XFAD Mouse. [PDF]

J Neurosci, 2016
Dinkins MB, Enasko J, Hernandez C, Wang G, Kong J, Helwa I, Liu Y, Terry AV, Bieberich E.   +8 more
europepmc   +1 more source

P53-dependent upregulation of neutral sphingomyelinase-2: role in doxorubicin-induced growth arrest. [PDF]

Cell Death Dis, 2015
Shamseddine AA, Clarke CJ, Carroll B, Airola MV, Mohammed S, Rella A, Obeid LM, Hannun YA.   +7 more
europepmc   +1 more source

Sphingolipid Metabolism Links Morphological Signatures to Immunomodulatory Potency in Human Mesenchymal Stromal Cells. [PDF]

Cell Mol Bioeng
Shah DC, Leitmann BW, Priyadarshani P, DeVeaux SA, Munoz C, Zhang Y, Rui K, Chiappa NF, Hymel LA, York W, Ogle ME, Botchwey EA, Mortensen LJ.   +12 more
europepmc   +1 more source

Analysis of membrane topology of neutral sphingomyelinase 2 [PDF]

FEBS Letters, 2007
Neutral sphingomyelinase 2 (nSMase2), which has two hydrophobic segments at its NH2‐terminus, plays an important role in ceramide‐mediated cell regulation. Here, we investigated the membrane topology of nSMase2. When a double‐tagged nSMase2 at both the NH2 and COOH termini, was overexpressed in MCF‐7 cells, the signals from both tags were detected in ...
Yusuf A. Hannun, Motohiro Tani
exaly   +3 more sources

Stimulation of neutral, magnesium-stimulated sphingomyelinase activity in the neurohypophysis of the rat by hypertonic saline ingestion

Brain Research Bulletin, 1983
Neutral, magnesium-stimulated sphingomyelinase and acid sphingomyelinase activities in the neurohypophysis, adenohypophysis and cerebrum of rats given 2.25% NaCl drinking water for 7 or 14 days were compared with the same enzyme activities in the tissues
H W Cook, M W Spence, M W Spence
exaly   +1 more source

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Identification and evaluation of neutral sphingomyelinase 2 inhibitors

Archives of Pharmacal Research, 2011
Sphingomyelinase catalyzes the hydrolysis of sphingomyelin to generate ceramide, an important molecule involved in the regulation of various cellular responses. In this study, we partially purified the neutral sphingomyelinase2 (nSMase2) and identified the inhibitors, D-lyxophytosphingosine and D-arabino-phytosphingosine, which have an inhibitory ...
Dong Hun, Lee, Sung Hyun, Kim, Kyong Hoon, Ahn, Seok Kyun, Kim, Jong Min, Choi, Jung Eun, Ji, Jong Hoon, Won, Yang Hui, Park, Chaemin, Lim, Sanghee, Kim, Dae Kyong, Kim   +10 more
openaire   +2 more sources

Niemann-Pick Type A Disease: Behavior of Neutral Sphingomyelinase and Vitamin D Receptor

International Journal of Molecular Sciences, 2019
Sphingomyelinase (SMase) is responsible for the breakdown of sphingomyelin (SM) with production of ceramide. The absence of acid sphingomyelinase (aSMase) causes abnormal synapse formation in Niemann-Pick type A (NPA) disease.
Carmela Conte, Federica Filomena Patria, Tommaso Beccari   +2 more
exaly   +2 more sources