Results 101 to 110 of about 91,612,173 (178)
BMC Complementary and Alternative Medicine, 2013 Abstract Background Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated
Park, Bonggoo +6 more
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International Journal of Nanomedicine, 2021 Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, KoreaCorrespondence: Sangiliyandi Gurunathan; Jin-Hoi KimDepartment of Stem Cell and ...
Gurunathan S, Kang MH, Jeyaraj M, Kim JH
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Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis
Journal of Extracellular BiologyExtracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman +8 more
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Regulation of neutral ceramidase in glomerular messangial cells [PDF]
, 2009 During the past several years, ceramide has emerged as an important second messenger triggering cell responses including proliferation, differentiation, growth arrest and apoptosis.
Franzen, Rochus
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Journal of Lipid Research, 2010 Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity.
Marcin Baranowski +7 more
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Chromatin neutral sphingomyelinase and its role in hepatic regeneration
, 1997 Ceramide acts as a second messenger and modulates many cellular functions. This molecule can be produced by enzymatic digestion of sphingomyelin, a phospholipid which has been shown to be in high concentration in a chromatin phospholipidic fraction.
Viola Magni, M. P., ALBI, Elisabetta
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Biochemistry and Biophysics Reports, 2016 Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
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Lysosomal sphingomyelinase is not solicited for apoptosis signaling
, 2000 International audienceABSTRACT Stress‐induced activation of an acidic sphingomyelinase leading to generation of ceramide, an important lipid mediator, has been associated with apoptosis; however, the implication of this hydrolase has been questioned. The
Gouazé, Valérie +11 more
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Role and regulation of neutral sphingomyelinase-2 in response to DNA damage [PDF]
, 2015 Neutral sphingomylinase-2 (nSMase2) is a ceramide-generating enzyme that has been implicated in growth arrest, apoptosis and exosome secretion. In this thesis, we show that doxorubicin induces a dose-dependent induction of nSMase2 mRNA and protein levels
Shamseddine, Achraf
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