Results 81 to 90 of about 91,612,173 (178)

Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase

Molecular Cancer, 2010
Background Ceramide is an important second messenger that has diverse cellular and biological effect. It is a specific and potent inducer of apoptosis and suppressor of cell growth.
Mondal Susmita, Mandal Chandan, Sangwan Rajender, Chandra Sarmila, Mandal Chitra   +4 more
doaj   +1 more source

Heparin Can Augment Extracellular Vesicle Yield by Inhibiting Reuptake in Donor Cells During Cell Propagation

Journal of Extracellular Vesicles, Volume 15, Issue 10, October 2026.
Heparin augments EV yield in culture by inhibiting EV binding to cell‐surface HSPG and masking EV surface. Preventing autocrine and homotypic paracrine EV uptake during cell culture results in EV accumulation and higher yield. Heparin improved EV recovery after storage in NaCl but not in complex media or protein‐rich buffer(Please see Figure 9 for ...
André Cronemberger Andrade, Rodolphe Poupardin, Martin Wolf, Liliia Paniushkina, Karim Selmi, Deepika Kundully Suresh, Nicole Maeding, Heide‐Marie Binder, Janine Zwicklhuber, Sarah Hochmann, André Görgens, Samir El Andaloussi, Katharina Schallmoser, Dirk Strunk   +13 more
wiley   +1 more source

Inhibition of neutral sphingomyelinase‐2 perturbs brain sphingolipid balance and spatial memory in mice [PDF]

Journal of Neuroscience Research, 2010
AbstractThe sphingolipid ceramide is a bioactive signaling lipid that is thought to play important roles in modulating synaptic activity, in part by regulating the function of excitatory postsynaptic receptors. However, the molecular mechanisms by which ceramide exerts its effects on synaptic activity remain largely unknown.
Nino, Tabatadze, Alena, Savonenko, Hongjun, Song, Veera Venkata Ratnam, Bandaru, Michael, Chu, Norman J, Haughey   +5 more
openaire   +2 more sources

Ursodeoxycholic acid differentially affects three types of sphingomyelinase in human colon cancer Caco 2 cells. [PDF]

, 2006
We investigated the effects of UDCA on sphingomyelinase (SMase) in Caco 2 cells cultured in monolayer and polarized conditions. Alkaline SMase activity was high in polarized cells whereas.
Wu, Jun, Duan, Rui-Dong, Tauschel, Horst-Dietmar, Liu, Fuli, Cheng, Yajun, Wu, Jun,, Liu, Fuli,, Duan, Rui-Dong,, Cheng, Yajun,, Lund University.   +9 more
core   +1 more source

Senescent Cell‐Derived Extracellular Vesicles in Therapy‐Induced Senescence: Immune Remodelling and Emerging Links to Mitochondrial Stress in Cancer

Journal of Extracellular Biology, Volume 5, Issue 10, October 2026.
ABSTRACT Cancer therapy can induce cellular senescence and remodel the tumour microenvironment through the senescence‐associated secretory phenotype (SASP), including its membrane‐enclosed component, senescent cell‐derived extracellular vesicles (senEVs). This review summarizes senEV biogenesis, cargo‐dependent functions, and immune‐remodelling effects
Yongrui Qian, Zirui Weng, Na Li, Yun Zhou, Hailong Pei   +4 more
wiley   +1 more source

Extracellular Vesicles: Classification, Biological Functions, Diseases, and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
• EV content maintains cellular homeostasis and is involved in several disease onset and progression. • miRNA export in EVs depends on: RNA‐binding proteins recognizing motif sequences and on epitranscriptomic modifications. • The disclosure of delivery mechanisms is crucial for developing personalized EV‐based therapeutic tools. ABSTRACT Extracellular
Sabrina Garbo, Francesco Marocco, Clemens Zwergel, Marco Tripodi, Cecilia Battistelli   +4 more
wiley   +1 more source

Inhibition of neutral sphingomyelinase-2 restrains enterovirus 71 infection by autophagy

Microbial Pathogenesis
Enterovirus 71 (EV-71) is a major pathogenic factor that causes hand, foot, and mouth disease in young children and infants. Given the limited treatments for EV-71 infection, discovering new host factors and understanding the mechanisms involved will aid in combating this viral infection.
Jing, Wu, Jian, Lu, Mingzhi, Pan, Xiaochu, Gu, Yun, Wang, Lu, Dai   +5 more
openaire   +2 more sources

Role for Mammalian Neutral Sphingomyelinase 2 in Confluence-induced Growth Arrest of MCF7 Cells [PDF]

Journal of Biological Chemistry, 2004
Recently, we reported that neutral sphingomyelinase 2 (nSMase2) functions as a bona fide neutral sphingomyelinase and that overexpression of nSMase2 in MCF7 breast cancer cells caused a decrease in cell growth (Marchesini, N., Luberto, C., and Hannun, Y. A. (2003) J. Biol. Chem. 278, 13775-13783).
Norma, Marchesini, Walid, Osta, Jacek, Bielawski, Chiara, Luberto, Lina M, Obeid, Yusuf A, Hannun   +5 more
openaire   +2 more sources

Sphingomyelinase Disables Inactivation in Endogenous PIEZO1 Channels [PDF]

, 2020
Endogenous PIEZO1 channels of native endothelium lack the hallmark inactivation often seen when these channels are overexpressed in cell lines. Because prior work showed that the force of shear stress activates sphingomyelinase in endothelium, we ...
Beech, David J., Lichtenstein, Laeticia, Futers, Simon T., Shi, Jian, Lichtenstein, L, Chong, Jiehan, Hyman, Adam J., Chong, J, Shi, J, Kalli, AC, Beech, DJ, Auge, Nathalie, Salvayre, AN, Kalli, Antreas, Rouahi, Myriam, Rouahi, M, Negre Salvayre, Anne, Hyman, AJ, De Vecchis, D, De Vecchis, Dario, Futers, TS, Auge, N   +21 more
core   +1 more source

Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation.

Am J Physiol Lung Cell Mol Physiol, 2015
Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood. It is known, however, that cytokines activate neutral sphingomyelinase (nSMase) and nSMase has downstream effects with the potential to increase calpain activity. We tested the hypothesis that infection-
Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA.   +4 more
europepmc   +4 more sources