Results 81 to 90 of about 8,475 (148)

Regulation of neutral sphingomyelinase-2 by GSH: a new insight to the role of oxidative stress in aging-associated inflammation

Journal of Lipid Research, 2007
Oxidative stress and inflammation are fundamental for the onset of aging and appear to be causatively linked. Previously, we reported that hepatocytes from aged rats, compared with young rats, are hyperresponsive to interleukin-1β (IL-1β) stimulation and
Kristina Rutkute, Reto H. Asmis, Mariana N. Nikolova-Karakashian   +2 more
doaj   +1 more source

The regulation of T cell metabolism by neutral sphingomyelinase 2

, 2020
T cells play an essential role in the immune system. Engaging the T cell receptor (TCR) initiates a cascade of signaling events that activates the T cells. Neutral sphingomyelinase (NSM) is a member of a superfamily of enzymes responsible for the hydrolysis of sphingomyelin into phosphocholine and ceramide.
openaire   +2 more sources

Metal‐dependent regulated cell death: Molecular architecture and translational frontiers

iMeta, Volume 5, Issue 3, June 2026.
Intracellular metal dyshomeostasis orchestrates distinct regulated cell death programs, including iron‐driven ferroptosis, copper‐mediated cuproptosis, calcicoptosis, newly designated zincoptosis, mnoptosis, and coptosis. This review systematically delineates their molecular architectures—spanning from Sorafenib‐induced lipid peroxidation and ...
Haoliang Hu, Zhe Chen, Yaqi Li, Jiayi Peng, Jiangang Cao, Hong Zhou, Mengqi Wang, Yuejia Du, Hailin Wu, Huiqin Zhao, Shifang Huang, Dianmei Yu, Meiqing Liu, Olga V. Shevchenko, Natalia Yu. Matveeva, Yiyuan Yang, Kerui Huang, Deguan Lv, Junxia Min, Linxi Chen, Fudi Wang   +20 more
wiley   +1 more source

Platinum Nanoparticles Enhance Exosome Release in Human Lung Epithelial Adenocarcinoma Cancer Cells (A549): Oxidative Stress and the Ceramide Pathway are Key Players

International Journal of Nanomedicine, 2021
Sangiliyandi Gurunathan, Min-Hee Kang, Muniyandi Jeyaraj, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, KoreaCorrespondence: Sangiliyandi Gurunathan; Jin-Hoi KimDepartment of Stem Cell and ...
Gurunathan S, Kang MH, Jeyaraj M, Kim JH
doaj  

Heparanase‐Loaded CAR T Extracellular Vesicles Remodel the Colorectal Tumour Microenvironment and Boost T Cell Antitumor Immunity

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Dense ECM restricts CAR T efficacy in solid tumours. Zhu et al. design mesothelin‐targeted CAR T cells that secrete heparanase‐rich extracellular vesicles via a truncated hepatitis A virus pX domain (pX‐Δ1‐30), promoting ECM degradation, durable memory, and less exhausted phenotypes, leading to strong antitumor responses in colorectal cancer spheroids ...
Songshan Zhu, Jun Yin, Weiqiang Yang, Xin Fu, Yiwei Zeng, Na Huang, Ling Zhang, Cong Yu, Ping Ouyang, Kaisong Huang, Rui Chen, Xiaolei Zhao, Dan Jiang, Guangxian Xu   +13 more
wiley   +1 more source

Myocardium of type 2 diabetic and obese patients is characterized by alterations in sphingolipid metabolic enzymes but not by accumulation of ceramide[S]

Journal of Lipid Research, 2010
Data from animal experiments strongly suggest that ceramide is an important mediator of lipotoxicity in the heart and that accumulation of ceramide contributes to cardiomyocyte apoptosis associated with type 2 diabetes and obesity.
Marcin Baranowski, Agnieszka Blachnio-Zabielska, Tomasz Hirnle, Dorota Harasiuk, Krzysztof Matlak, Malgorzata Knapp, Piotr Zabielski, Jan Gorski   +7 more
doaj   +1 more source

Neutral sphingomyelinase 2 modulates cytotoxic effects of protopanaxadiol on different human cancer cells

BMC Complementary and Alternative Medicine, 2013
Abstract Background Some of ginsenosides, root extracts from Panax ginseng, exert cytotoxicity against cancer cells through disruption of membrane subdomains called lipid rafts. Protopanaxadiol (PPD) exhibits the highest cytotoxic effect among 8 ginsenosides which we evaluated for anti-cancer activity. We investigated
Park, Bonggoo, Lee, Yong-Moon, Kim, Jae-Sung, Her, Youl, Kang, Ju Hee, Oh, Seung-Hyun, Kim, Hwan-Mook   +6 more
openaire   +3 more sources

Challenging the conventional wisdom: Re‐evaluating Smpd3's role in extracellular vesicle biogenesis

Journal of Extracellular Biology
Extracellular vesicles (EVs) are pivotal in intercellular communication, impacting diverse physiological and pathological processes. Current in vitro EV biogenesis studies often utilize pharmacological inhibitors, inducing off‐target effects and ...
Marlies Burgelman, Pieter Dujardin, Anthony Willems, Tino Hochepied, Griet Van Imschoot, Elien Van Wonterghem, Lien Van Hoecke, Charysse Vandendriessche, Roosmarijn E. Vandenbroucke   +8 more
doaj   +1 more source

Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells

Biochemistry and Biophysics Reports, 2016
Statins have pleiotropic properties which are involved in inhibiting the thrombogenic response. In this study, the effects of lovastatin on two phospholipids, phosphatidylcholine and sphingomyelin, were studied in cultured endothelial cells in the ...
Qi Zhou, Allan Luo, Fred A Kummerow
doaj   +1 more source

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S]

Journal of Lipid Research, 2016
Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional ...
Christopher J. Clarke, Achraf A. Shamseddine, Joseph J. Jacob, Gabrielle Khalife, Tara A. Burns, Yusuf A. Hannun   +5 more
doaj   +1 more source