Results 61 to 70 of about 91,612,173 (178)

Membrane lipid metabolism as a regulatory frontier in neural crest biology: Roles for sphingolipids, cholesterol, and lipid rafts

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are multipotent, migratory stem‐like cells essential for vertebrate development that contribute broadly to many tissues including the craniofacial skeleton, peripheral nervous system, and pigment‐producing cells. Their development progresses through phases of induction, specification, delamination, migration, and ...
Allison E. Mancini, Mallorie P. Jenne, Michael L. Piacentino   +2 more
wiley   +1 more source

A key role for matrix metalloproteinases and neutral sphingomyelinase-2 in transplant vasculopathy triggered by anti-HLA antibody.

, 2011
International audienceBACKGROUND: Outcomes for organ transplantation are constantly improving because of advances in organ preservation, surgical techniques, immune clinical monitoring, and immunosuppressive treatment preventing acute transplant ...
Nathalie Augé, Denis Calise, Jean-Claude Thiers, Hans-Willi Krell, Augé, Nathalie, Salvayre, Robert, Magali Trayssac, Rostaing, Lionel, Anne Nègre-Salvayre, Nassim Kamar, Sylvain Galvani, Federico Sallusto, Kamar, Nassim, Mogens Thomsen, Trayssac, Magali, Calise, Denis, Krell, Hans-Willi, Thomsen, Mogens, Robert Salvayre, Thiers, Jean-Claude, Galvani, Sylvain, Lionel Rostaing, Sallusto, Federico, Nègre-Salvayre, Anne   +23 more
core   +1 more source

Mycobacterial Infection is Promoted by Neutral Sphingomyelinase 2 Regulating a Signaling Cascade Leading to Activation of β1-Integrin

Cellular Physiology and Biochemistry, 2018
Background/Aims: Mycobacteria-induced diseases, especially tuberculosis, cause more than 1 million deaths each year, which is higher than any other single bacterial pathogen.
Yuqing Wu, Cao Li, Andrea Riehle, Barbara Pollmeier, Erich Gulbins, Heike Grassmé   +5 more
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Endothelin-1 stimulates small artery VCAM-1 expression through p38MAPK-dependent neutral sphingomyelinase

, 2012
Endothelin-1 (ET-1) stimulates vascular cell adhesion molecule (VCAM-1) expression, a process associated with arterial remodelling. However, the pathways activated by ET-1 that lead to VCAM-1 expression are not fully understood.
Katzenberg, Gideon, Ohanian, Jacqueline, Ohanian, Vasken, Forman, Simon P.   +3 more
core   +1 more source

Endothelial cell CD36 regulates membrane ceramide formation, exosome fatty acid transfer and circulating fatty acid levels

Nature Communications, 2023
Endothelial cell (EC) CD36 controls tissue fatty acid (FA) uptake. Here we examine how ECs transfer FAs. FA interaction with apical membrane CD36 induces Src phosphorylation of caveolin-1 tyrosine-14 (Cav-1Y14) and ceramide generation in caveolae ...
V. S. Peche, T. A. Pietka, M. Jacome-Sosa, D. Samovski, H. Palacios, G. Chatterjee-Basu, A. C. Dudley, W. Beatty, G. A. Meyer, I. J. Goldberg, N. A. Abumrad   +10 more
doaj   +1 more source

Mechanisms of Arachidonic Acid In Vitro Tumoricidal Impact

Molecules, 2023
To promote the potential of arachidonic acid (ARA) for cancer prevention and management, experiments were implemented to disclose the mechanisms of its tumoricidal action.
Hatem Tallima, Rashika El Ridi
doaj   +1 more source

Advances in Radiotherapy for Neoadjuvant Therapy of Stage III Non‐Small Cell Lung Cancer

Cancer Science, EarlyView.
This review summarizes three neoadjuvant radiotherapy techniques for stage III NSCLC, highlighting SFRT's low‐toxicity dual immune‐tumor control benefits and radioimmunotherapy's superior pathological response to guide precise multimodal treatment. ABSTRACT This review aims to systematically summarize the mechanisms of action, clinical evolution, and ...
Qinrong Mao, Yuanchun Yu, Yan Fang, Shaofeng Zhu, Chengjin Tang, Jing Cai   +5 more
wiley   +1 more source

Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease

JCI Insight, 2021
IL-33 is a key mediator of chronic airway disease driven by type 2 immune pathways, yet the nonclassical secretory mechanism for this cytokine remains undefined.
Ella Katz-Kiriakos, Deborah F. Steinberg, Colin E. Kluender, Omar A. Osorio, Catie Newsom-Stewart, Arjun Baronia, Derek E. Byers, Michael J. Holtzman, Dawn Katafiasz, Kristina L. Bailey, Steven L. Brody, Mark J. Miller, Jennifer Alexander-Brett   +12 more
doaj   +1 more source

Cytotoxicity Profiling of Tenacibaculum Extracellular Products on Chinook Salmon (Oncorhynchus tshawytscha) Gill Cell Line, OTgill1PFR

Journal of Fish Diseases, EarlyView.
ABSTRACT Tenacibaculosis is an important disease of marine fishes caused by bacteria of the genus Tenacibaculum. Pathogenic Tenacibaculum species or serotypes, including Tenacibaculum maritimum, T. dicentrarchi, T. finnmarkense and T. soleae, have been isolated from farmed Chinook salmon (Oncorhynchus tshawytscha) during disease outbreaks in Aotearoa ...
Bjorn Böhmert, Michael Algie, Karthiga Kumanan, Kate S. Hutson, Georgina C. Dowd   +4 more
wiley   +1 more source