Results 71 to 80 of about 91,612,173 (178)
ASN Neuro, 2022 Psychosine exerts most of its toxic effects by altering membrane dynamics with increased shedding of extracellular vesicles (EVs). In this study, we discovered that a fraction of psychosine produced in the brain of the Twitcher mouse, a model for Krabbe ...
Cory R. Reiter +14 more
doaj +1 more source
Periodontology 2000, EarlyView.Abstract Background Extracellular vesicles (EVs), especially exosomes, are nanoparticles increasingly recognized as key regulators of intercellular communication in both physiological and pathological aspects. Despite rapid progress, inconsistencies in nomenclature, isolation, and characterization continue to restrict translational advancement.
Paras Ahmad +6 more
wiley +1 more source
, 2008 Supplementary Tables S1-S4 from Neutral Sphingomyelinase-3 Is a DNA Damage and Nongenotoxic Stress-Regulated Gene That Is Deregulated in Human ...
Chad A. Corcoran (15088119) +5 more
core +1 more source
Molecules, 2021 Type 1 diabetes (T1D) development, in part, is due to ER stress-induced β-cell apoptosis. Activation of the Ca2+-independent phospholipase A2 beta (iPLA2β) leads to the generation of pro-inflammatory eicosanoids, which contribute to β-cell death and T1D.
Tomader Ali +5 more
doaj +1 more source
Biotechnology and Bioengineering, Volume 123, Issue 11, Page 3079-3105, November 2026.ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu +23 more
wiley +1 more source
Exosomes in Cancer: The Biology, Function, Diagnosis, and Therapy
MedComm, Volume 7, Issue 11, November 2026.Tumor‐derived exosomes and nonmembranous extracellular nanoparticles (exomeres/supermeres) constitute a heterogeneous communication network that drives cancer progression. By shuttling functional biomolecules across tissue‐specific barriers, these nanoparticles orchestrate local microenvironmental remodeling, immune suppression, premetastatic niche ...
Jun Wu +8 more
wiley +1 more source
Apoptosis and signalling in acid sphingomyelinase deficient cells [PDF]
, 2000 Background Recent evidence suggests that the activation of a non-specific lipid scramblase during apoptosis induces the flipping of sphingomyelin from the cell surface to the cytoplasmic leaftet of the plasma membrane. Inner leaflet sphingomyelin is then
Sillence Dan J +3 more
core +1 more source
Loss of Acid Ceramidase in Myeloid Cells Protects From Chronic Colitis in IL10‐Deficient Mice
The FASEB Journal, Volume 40, Issue 20, 31 October 2026.Acid ceramidase converts ceramide to sphingosine which can then be converted to sphingosine‐1‐phosphate, a bioactive lipid involved in inflammation. Loss of acid ceramidase in myeloid cells protects from chronic colitis by reducing pro‐inflammatory markers, increasing ceramides, and reducing effector immune cells in the colon.
Keila S. Espinoza +13 more
wiley +1 more source
Src regulates cigarette smoke-induced ceramide generation via neutral sphingomyelinase 2 in the airway epithelium. [PDF]
Am J Respir Cell Mol Biol, 2015 We previously demonstrated that the neutral sphingomyelinase (nSMase) 2 is the sole sphingomyelinase activated during cigarette smoke (CS)-induced oxidative stress of human airway epithelial cells, leading to ceramide generation and subsequent apoptosis ...
Chung S, Vu S, Filosto S, Goldkorn T.
europepmc +2 more sources
Comprehensive Physiology, Volume 16, Issue 5, October 2026.High fat, high fructose, high cholesterol “GAN” diet feeding in mice induces MASLD, cardiac dysfunction, loss of lean mass, and hyperinsulinaemia. Hepatocyte‐specific deletion of HIF2α also causes cardiac dysfunction and loss of lean mass but prevents GAN induced hyperinsulinaemia and cardiac sympathetic dominance without preventing MASLD.
Lorenz M. W. Holzner +15 more
wiley +1 more source