Results 41 to 50 of about 8,475 (148)

Neutral sphingomyelinase 2 deficiency is associated with lung anomalies similar to emphysema [PDF]

Mammalian Genome, 2012
Neutral sphingomyelinase 2 (nSMase2) upregulation was recently demonstrated to serve as a molecular link between smoke inhalation and emphysematous changes in lungs. Here we report that nSMase2 deficit impairs lung development in mice. We have shown previously that fragilitas ossium (fro) mice carry a mutation in the Smpd3 gene, rendering nSMase2 ...
Christophe, Poirier, Evgeny V, Berdyshev, Christiana, Dimitropoulou, Natalia V, Bogatcheva, Paul W, Biddinger, Alexander D, Verin   +5 more
openaire   +2 more sources

Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. [PDF]

PLoS ONE, 2010
BACKGROUND:Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different ...
Raphael Devillard, Sylvain Galvani, Jean-Claude Thiers, Jean-Louis Guenet, Yusuf Hannun, Jacek Bielawski, Anne Nègre-Salvayre, Robert Salvayre, Nathalie Augé   +8 more
doaj   +1 more source

Microglial-Targeted nSMase2 Inhibitor Fails to Reduce Tau Propagation in PS19 Mice

Pharmaceutics, 2023
The progression of Alzheimer’s disease (AD) correlates with the propagation of hyperphosphorylated tau (pTau) from the entorhinal cortex to the hippocampus and neocortex.
Meixiang Huang, Carolyn Tallon, Xiaolei Zhu, Kaitlyn D. J. Huizar, Silvia Picciolini, Ajit G. Thomas, Lukas Tenora, Wathsala Liyanage, Francesca Rodà, Alice Gualerzi, Rangaramanujam M. Kannan, Marzia Bedoni, Rana Rais, Barbara S. Slusher   +13 more
doaj   +1 more source

Neutral sphingomyelinase 2 ( smpd3 ) in the control of postnatal growth and development [PDF]

Proceedings of the National Academy of Sciences, 2005
Neutral sphingomyelinases sphingomyelin phosphodiesterase (SMPD)2 and -3 hydrolyze sphingomyelin to phosphocholine and ceramide. smpd2 is expressed ubiquitously, and smpd3 is expressed predominantly in neurons of the CNS.
Wilhelm, Stoffel, Britta, Jenke, Barbara, Blöck, Markus, Zumbansen, Jürgen, Koebke   +4 more
openaire   +2 more sources

Very Long-Chain C24:1 Ceramide Is Increased in Serum Extracellular Vesicles with Aging and Can Induce Senescence in Bone-Derived Mesenchymal Stem Cells

Cells, 2019
Extracellular vesicles (EVs), including exosomes and microvesicles, function in cell-to-cell communication through delivery of proteins, lipids and microRNAs to target cells via endocytosis and membrane fusion.
Andrew Khayrullin, Priyanka Krishnan, Luis Martinez-Nater, Bharati Mendhe, Sadanand Fulzele, Yutao Liu, Julie A. Mattison, Mark W. Hamrick   +7 more
doaj   +1 more source

Identification of Heat Shock Protein 60 as a Regulator of Neutral Sphingomyelinase 2 and Its Role in Dopamine Uptake. [PDF]

PLoS ONE, 2013
Activation of sphingomyelinase (SMase) by extracellular stimuli is the major pathway for cellular production of ceramide, a bioactive lipid mediator acting through sphingomyelin (SM) hydrolysis.
Kyong-Hoon Ahn, Seok-Kyun Kim, Jong-Min Choi, Sung-Yun Jung, Jong-Hoon Won, Moon-Jung Back, Zhicheng Fu, Ji-Min Jang, Hae-Chan Ha, Dae-Kyong Kim   +9 more
doaj   +1 more source

Reduction of sphingomyelinase activity associated with progranulin deficiency and frontotemporal dementia

Neurobiology of Disease
Loss-of-function mutations affecting the lysosomal protein progranulin are a leading cause of frontotemporal dementia. Progranulin mutations cause abnormalities in lysosomal lipid processing, particularly of sphingolipids, major components of neural cell
Nicholas R. Boyle, Stephanie N. Fox, Aniketh S. Tadepalli, Nicholas T. Seyfried, Thomas Kukar, Eliana M. Ramos, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant, Erik D. Roberson   +12 more
doaj   +1 more source

Gene expression of ceramide metabolism enzymes in fat depots of different localization in cardiovascular diseases

Российский кардиологический журнал, 2023
Aim. To assess gene expression of enzymes of the sphingomyelinase pathway of ceramide biosynthesis and degradation in fat depots of various localization in patients with cardiovascular diseases.Material and methods.
O. V. Gruzdeva, E. V. Belik, Yu. A. Dyleva, E. G. Uchasova, A. V. Ponasenko, A. G. Kutikhin, V. E. Markova, E. E. Gorbatovskaya, E. V. Fanaskova, S. V. Ivanov, A. N. Stasev, M. G. Zinets, T. A. Slesareva, O. L. Barbarash   +13 more
doaj   +1 more source

Hyaluronan synthase-2 upregulation protects smpd3-deficient fibroblasts against cell death induced by nutrient deprivation, but not against apoptosis evoked by oxidized LDL

Redox Biology, 2015
The neutral type 2 sphingomyelinase (nSMase2) hydrolyzes sphingomyelin and generates ceramide, a major bioactive sphingolipid mediator, involved in growth arrest and apoptosis.
Sandra Garoby-Salom, Myriam Rouahi, Elodie Mucher, Nathalie Auge, Robert Salvayre, Anne Negre-Salvayre   +5 more
doaj   +1 more source

Anterograde and retrograde transport of neutral sphingomyelinase-2 between the Golgi and the plasma membrane [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2010
The activation of neutral sphingomyelinase-2 (nSMase2) and consequent ceramide production are implicated in many stress-induced signaling pathways. Trafficking of nSMase2 from the Golgi compartment to the plasma membrane (PM) in response to signaling stimuli has been described. However, the precise mechanisms of transport remain unknown.
Delphine, Milhas, Christopher J, Clarke, Jolanta, Idkowiak-Baldys, Daniel, Canals, Yusuf A, Hannun   +4 more
openaire   +2 more sources