Stress induces major depressive disorder by a neutral sphingomyelinase 2-mediated accumulation of ceramide-enriched exosomes in the blood plasma. [PDF]
J Mol Med (Berl), 2022 Major depressive disorder (MDD) is a very common, severe disease with a lifetime prevalence of ~ 10%. The pathogenesis of MDD is unknown and, unfortunately, therapy is often insufficient.
Schumacher F +11 more
europepmc +4 more sources
Inhibition of neutral sphingomyelinase 2 promotes remyelination. [PDF]
Sci Adv, 2020 Targeting a sphingomyelin hydrolase improves the structure of remyelinated fibers in a mouse model of multiple sclerosis.
Yoo SW +11 more
europepmc +4 more sources
Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR) [PDF]
Antioxidants, 2019 Membrane-associated estrogen receptors (ER)-α36 and G protein-coupled estrogen receptor (GPER) play important roles in the estrogen’s rapid non-genomic actions including stimulation of cell proliferation.
Tetsuro Ishii, Eiji Warabi
doaj +2 more sources
PLoS ONE, 2018 Expression of Concern: Stress-Induced Sphingolipid Signaling: Role of Type-2 Neutral Sphingomyelinase in Murine Cell Apoptosis and ...
PLOS ONE Editors
doaj +2 more sources
Vascular Smooth Muscle Cell Neutral Sphingomyelinase 2 in the Release of Exosomes and Vascular Calcification. [PDF]
Int J Mol Sci, 2022 Vascular calcification (VC) is the pathological precipitation of calcium salts in the walls of blood vessels. It is a risk factor for cardiovascular events and their associated mortality. VC can be observed in a variety of cardiovascular diseases and is most prominent in diseases that are associated with dysregulated mineral homeostasis such as in ...
Pavlic A +5 more
europepmc +4 more sources
J Cell Sci, 2022 During endosome maturation, neutral sphingomyelinase 2 (nSMase2) is involved in intraluminal vesicles (ILVs) budding into late endosomes or multivesicular bodies (MVBs).
Choezom D, Gross JC.
europepmc +2 more sources
Neutral sphingomyelinase 2: A promising drug target for CNS disease. [PDF]
Adv PharmacolNeutral sphingomyelinase 2 (nSMase2), encoded by the SMPD3 gene, is a pivotal enzyme in sphingolipid metabolism, hydrolyzing sphingomyelin to produce ceramide, a bioactive lipid involved in apoptosis, inflammation, membrane structure, and extracellular vesicle (EV) biogenesis.
Huang M +7 more
europepmc +3 more sources
The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. [PDF]
Int J Mol SciThe accumulation of lipid droplets (LDs) and ceramides (Cer) is linked to non-alcoholic fatty liver disease (NAFLD), regularly co-existing with type 2 diabetes and decreased immune function. Chronic inflammation and increased disease severity in viral infections are the hallmarks of the obesity-related immunopathology.
Schempp R +11 more
europepmc +3 more sources
Neutral Sphingomyelinase 2 [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2011 Abstract Chronic obstructive pulmonary disease (COPD) is caused by exposure to cigarette smoke (CS). One mechanism of CS-induced lung injury is aberrant generation of ceramide, which leads to elevated apoptosis of epithelial and endothelial cells in the alveolar spaces.
Simone Filosto +9 more
openaire +1 more source
Regulation of brain aging by neutral sphingomyelinase 2 [PDF]
, 2021 Abstract We have shown that deficiency of neutral sphingomyelinase 2 (nSMase2), an enzyme generating the sphingolipid ceramide, improves memory in adult mice. Here, we performed sphingolipid and RNA-seq analyses on the cortex from 10 month-old nSMase2-deficient ( fro/fro ) and ...
Zhihui Zhu +11 more
openaire +1 more source