Results 21 to 30 of about 8,475 (148)

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease. [PDF]

J Med Chem, 2020
Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase of brain nSMase2 activity and related exosome release have been implicated in various pathological ...
Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R.   +16 more
europepmc   +5 more sources

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold. [PDF]

Eur J Med Chem, 2023
Neutral sphingomyelinase 2 (nSMase2) has gained increasing attention as a therapeutic target to regulate ceramide production in various disease conditions. Phenyl (R)-(1-(3-(3,4-dimethoxyphenyl)-2,6-dimethylimidazo[1,2-b]pyridazin-8-yl)-pyrrolidin-3-yl)carbamate (PDDC) is a submicromolar nSMase2 inhibitor and has been widely used to study the ...
Novotna K, Thomas AG, Stepanek O, Murphy B, Hin N, Skacel J, Mueller L, Tenora L, Pal A, Alt J, Wu Y, Paule J, Rais R, Slusher BS, Tsukamoto T.   +14 more
europepmc   +3 more sources

Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. [PDF]

Adv Biol Regul, 2015
Our understanding of the functions of ceramide signaling has advanced tremendously over the past decade. In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin.
Shamseddine AA, Airola MV, Hannun YA.
europepmc   +4 more sources

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis [PDF]

Frontiers in Cell and Developmental Biology, 2019
The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling.
Charlene Börtlein, Fabian Schumacher, Fabian Schumacher, Burkhard Kleuser, Lars Dölken, Elita Avota   +5 more
doaj   +2 more sources

Neutral sphingomyelinase 2 regulates inflammatory responses in monocytes/macrophages induced by TNF-α. [PDF]

Sci Rep, 2020
ABSTRACT Obesity is associated with elevated levels of TNF-α and proinflammatory CD11c monocytes /macrophages. TNF-α mediated dysregulation in the plasticity of monocytes/macrophages is concomitant with pathogenesis of several inflammatory diseases, including metabolic syndrome, but the underlying mechanisms are ...
Al-Rashed F, Ahmad Z, Thomas R, Melhem M, Snider AJ, Obeid LM, Al-Mulla F, Hannun YA, Ahmad R.   +8 more
europepmc   +5 more sources

Mechanism of Rapid Nuclear Factor-E2-Related Factor 2 (Nrf2) Activation via Membrane-Associated Estrogen Receptors: Roles of NADPH Oxidase 1, Neutral Sphingomyelinase 2 and Epidermal Growth Factor Receptor (EGFR) [PDF]

Antioxidants, 2019
Membrane-associated estrogen receptors (ER)-α36 and G protein-coupled estrogen receptor (GPER) play important roles in the estrogen’s rapid non-genomic actions including stimulation of cell proliferation.
Tetsuro Ishii, Eiji Warabi
doaj   +2 more sources

Staying sane in the membrane: Neutral sphingomyelinase 2 as a master regulator of plasma membrane ceramide [PDF]

Journal of Lipid Research
Zainuddin Quadri, Erhard Bieberich
doaj   +2 more sources

Neutral sphingomyelinase 2 is required for cytokine-induced skeletal muscle calpain activation.

Am J Physiol Lung Cell Mol Physiol, 2015
Calpain contributes to infection-induced diaphragm dysfunction but the upstream mechanism(s) responsible for calpain activation are poorly understood. It is known, however, that cytokines activate neutral sphingomyelinase (nSMase) and nSMase has downstream effects with the potential to increase calpain activity. We tested the hypothesis that infection-
Supinski GS, Alimov AP, Wang L, Song XH, Callahan LA.   +4 more
europepmc   +4 more sources

Regulation of brain aging by neutral sphingomyelinase 2 [PDF]

, 2021
Abstract We have shown that deficiency of neutral sphingomyelinase 2 (nSMase2), an enzyme generating the sphingolipid ceramide, improves memory in adult mice. Here, we performed sphingolipid and RNA-seq analyses on the cortex from 10 month-old nSMase2-deficient ( fro/fro ) and ...
Zhihui Zhu, Zainuddin Quadri, Simone M. Crivelli, Ahmed Elsherbini, Liping Zhang, Priyanka Tripathi, Haiyan Qin, Emily Roush, Stefka D. Spassieva, Mariana Nikolova-Karakashian, Timothy S. McClintock, Erhard Bieberich   +11 more
openaire   +1 more source

Analysis of membrane topology of neutral sphingomyelinase 2 [PDF]

FEBS Letters, 2007
Neutral sphingomyelinase 2 (nSMase2), which has two hydrophobic segments at its NH2‐terminus, plays an important role in ceramide‐mediated cell regulation. Here, we investigated the membrane topology of nSMase2. When a double‐tagged nSMase2 at both the NH2 and COOH termini, was overexpressed in MCF‐7 cells, the signals from both tags were detected in ...
Tani, Motohiro, Hannun, Yusuf A.
openaire   +2 more sources