Results 31 to 40 of about 91,612,173 (178)

Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3' kinase, and Akt

, 2003
Activation of endothelial nitric-oxide synthase (eNOS) has been shown to occur through various pathways involving increases in the cytosolic Ca(2+) concentration, activation of the phosphatidylinositol-3' kinase/Akt pathway, as well as regulation by ...
Clementi, E, Barsacchi, R, Moncada, S, Borgese, N, Perrotta, C, Bulotta, S   +5 more
core   +6 more sources

Novel Human Neutral Sphingomyelinase 2 Inhibitors as Potential Therapeutics for Alzheimer's Disease. [PDF]

J Med Chem, 2020
Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular communication. Chronic increase of brain nSMase2 activity and related exosome release have been implicated in various pathological ...
Šála M, Hollinger KR, Thomas AG, Dash RP, Tallon C, Veeravalli V, Lovell L, Kögler M, Hřebabecký H, Procházková E, Nešuta O, Donoghue A, Lam J, Rais R, Rojas C, Slusher BS, Nencka R.   +16 more
europepmc   +5 more sources

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Down-regulation of acid sphingomyelinase and neutral sphingomyelinase-2 inversely determines the cellular resistance to plasmalemmal injury by pore-forming toxins. [PDF]

, 2018
Bacterial pore-forming toxins compromise plasmalemmal integrity, leading to Ca2+ influx, leakage of the cytoplasm, and cell death. Such lesions can be repaired by microvesicular shedding or by the endocytic uptake of the injured membrane sites.
Roman Schoenauer, Patrick Drücker, Draeger, Annette, Yu Larpin, Eduard B. Babiychuk, Viktoriia S. Babiychuk, Schönauer, Roman, Elita Avota, Fabian Schumacher, Annette Draeger, Schneider-Schaulies, S, Schumacher, F, Avota, E, Drücker, Patrick, Burkhard Kleuser, Babiychuk, Eduard, Babiychuk, Victoria, Larpin, Yu-Noël, Sibylle Schneider-Schaulies, René Köffel, Köffel, René, Kleusner, B, Kleuser, Burkhard (Prof. Dr. rer. nat.), Babiychuk, Eduard B., Schoenauer R, Draeger A, Larpin Y, Drücker P, Schneider-Schaulies, Sibylle, Schumacher F, Babiychuk EB, Larpin, Yu, Schneider-Schaulies S, Babiychuk, Viktoriia S., Avota, Elita, Avota E, Köffel R, Kleuser B, Schoenauer, Roman, Babiychuk VS, Schumacher, Fabian (Dr.)   +40 more
core   +2 more sources

Zika virus propagation and release in human fetal astrocytes can be suppressed by neutral sphingomyelinase-2 inhibitor GW4869. [PDF]

Cell Discov, 2018
Zika virus (ZIKV) is a neurotrophic flavivirus that is capable of infecting humans, leading to brain abnormalities during fetal development. The ZIKV infectivity in neural target cells remains poorly understood.
Huang Y, Li Y, Zhang H, Zhao R, Jing R, Xu Y, He M, Peer J, Kim YC, Luo J, Tong Z, Zheng J.   +11 more
europepmc   +2 more sources

Roles and regulation of neutral sphingomyelinase-2 in cellular and pathological processes. [PDF]

Adv Biol Regul, 2015
Our understanding of the functions of ceramide signaling has advanced tremendously over the past decade. In this review, we focus on the roles and regulation of neutral sphingomyelinase 2 (nSMase2), an enzyme that generates the bioactive lipid ceramide through the hydrolysis of the membrane lipid sphingomyelin.
Shamseddine AA, Airola MV, Hannun YA.
europepmc   +4 more sources

Proinflammatory Stress Activates Neutral Sphingomyelinase 2-Based Generation of a Ceramide-Enriched β-Cell EV Subpopulation. [PDF]

Diabetes
β-Cell extracellular vesicles (EVs) play a role as paracrine effectors in islet health, yet mechanisms connecting β-cell stress to changes in EV cargo and potential impacts on diabetes remain poorly defined.
Xu J, Amalaraj I, De Oliveira A, Harris-Kawano A, Enriquez JR, Mirmira RG, Eder JG, Burnet MC, Díaz Ludovico I, Flores JE, Nakayasu ES, Sims EK.   +11 more
europepmc   +2 more sources

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Translational Neurodegeneration, 2023
Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered by ceramide
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher   +16 more
doaj   +1 more source

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Pharmaceutics, 2022
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs).
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher   +14 more
doaj   +1 more source

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization [PDF]

The Journal of Experimental Medicine, 2011
A deletion mutation called fro (fragilitas ossium) in the murine Smpd3 (sphingomyelin phosphodiesterase 3) gene leads to a severe skeletal dysplasia. Smpd3 encodes a neutral sphingomyelinase (nSMase2), which cleaves sphingomyelin to generate bioactive lipid metabolites.
Khavandgar, Zohreh, Poirier, Christophe, Clarke, Christopher J., Li, Jingjing, Wang, Nicholas, McKee, Marc D., Hannun, Yusuf A., Murshed, Monzur   +7 more
openaire   +2 more sources