Results 31 to 40 of about 8,475 (148)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Src Regulates Cigarette Smoke–Induced Ceramide Generation via Neutral Sphingomyelinase 2 in the Airway Epithelium [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2015
Simon Vu, Samuel Chung, Simone Filosto   +2 more
exaly   +2 more sources

Dendrimer-Conjugated nSMase2 Inhibitor Reduces Tau Propagation in Mice

Pharmaceutics, 2022
Alzheimer’s disease (AD) is characterized by the progressive accumulation of amyloid-β and hyperphosphorylated tau (pTau), which can spread throughout the brain via extracellular vesicles (EVs).
Carolyn Tallon, Benjamin J. Bell, Anjali Sharma, Arindom Pal, Medhinee M. Malvankar, Ajit G. Thomas, Seung-Wan Yoo, Kristen R. Hollinger, Kaleem Coleman, Elizabeth L. Wilkinson, Sujatha Kannan, Norman J. Haughey, Rangaramanujam M. Kannan, Rana Rais, Barbara S. Slusher   +14 more
doaj   +1 more source

Inhibiting tau-induced elevated nSMase2 activity and ceramides is therapeutic in an Alzheimer’s disease mouse model

Translational Neurodegeneration, 2023
Background Cognitive decline in Alzheimer’s disease (AD) is associated with hyperphosphorylated tau (pTau) propagation between neurons along synaptically connected networks, in part via extracellular vesicles (EVs). EV biogenesis is triggered by ceramide
Carolyn Tallon, Benjamin J. Bell, Medhinee M. Malvankar, Pragney Deme, Carlos Nogueras-Ortiz, Erden Eren, Ajit G. Thomas, Kristen R. Hollinger, Arindom Pal, Maja Mustapic, Meixiang Huang, Kaleem Coleman, Tawnjerae R. Joe, Rana Rais, Norman J. Haughey, Dimitrios Kapogiannis, Barbara S. Slusher   +16 more
doaj   +1 more source

A cell-autonomous requirement for neutral sphingomyelinase 2 in bone mineralization [PDF]

The Journal of Experimental Medicine, 2011
A deletion mutation called fro (fragilitas ossium) in the murine Smpd3 (sphingomyelin phosphodiesterase 3) gene leads to a severe skeletal dysplasia. Smpd3 encodes a neutral sphingomyelinase (nSMase2), which cleaves sphingomyelin to generate bioactive lipid metabolites.
Khavandgar, Zohreh, Poirier, Christophe, Clarke, Christopher J., Li, Jingjing, Wang, Nicholas, McKee, Marc D., Hannun, Yusuf A., Murshed, Monzur   +7 more
openaire   +2 more sources

Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson’s disease model

Molecular Brain, 2021
Aim We have previously reported that cambinol (DDL-112), a known inhibitor of neutral sphingomyelinase-2 (nSMase2), suppressed extracellular vesicle (EV)/exosome production in vitro in a cell model and reduced tau seed propagation.
Chunni Zhu, Tina Bilousova, Samantha Focht, Michael Jun, Chris Jean Elias, Mikhail Melnik, Sujyoti Chandra, Jesus Campagna, Whitaker Cohn, Asa Hatami, Patricia Spilman, Karen Hoppens Gylys, Varghese John   +12 more
doaj   +1 more source

Neutral Sphingomyelinase 2 (nSMase2) Is a Phosphoprotein Regulated by Calcineurin (PP2B) [PDF]

Journal of Biological Chemistry, 2010
We previously reported that exposure of human airway epithelial cells to oxidative stress increased ceramide generation via specific activation of neutral sphingomyelinase2 (nSMase2). Here we show that nSMase2 is a phosphoprotein exclusively phosphorylated at serine residues.
Simone, Filosto, William, Fry, Anne A, Knowlton, Tzipora, Goldkorn   +3 more
openaire   +2 more sources

Impact of HepG2 Cells Glutathione Depletion on Neutral Sphingomyelinases mRNA Levels and Activity

Current Issues in Molecular Biology, 2023
Liver cancer is a prevalent form of cancer worldwide. While research has shown that increasing sphingomyelin (SM) hydrolysis by activating the cell surface membrane-associated neutral sphingomyelinase 2 (nSMase2) can control cell proliferation and ...
Marie Gamal, Hatem Tallima, Hassan M. E. Azzazy, Anwar Abdelnaser   +3 more
doaj   +1 more source

A role for neutral sphingomyelinase activation in the inhibition of LPS action by phospholipid oxidation products

Journal of Lipid Research, 2006
Previous studies from our laboratory and others presented evidence that oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylcholine (OxPAPC) and oxidized 1-palmitoyl-2-arachidonyl-sn-glycero-3-phosphatidylethanolamine can inhibit ...
Kimberly A. Walton, Bogdan G. Gugiu, Miracle Thomas, Robert J. Basseri, Daniel R. Eliav, Robert G. Salomon, Judith A. Berliner   +6 more
doaj   +1 more source

Inhibition of neutral sphingomyelinase-2 facilitates remyelination [PDF]

, 2019
Abstract For reasons that are not completely understood, remyelination is often incomplete, producing thin myelin sheaths with disorganized structure. We investigated the cellular basis for this altered myelin structure, and found that the response of oligodendrocyte progenitor cells (OPCs), and mature ...
Yoo, Seung-Wan, Agarwal, Amit, Smith, Matthew D., Khuder, Saja S., Baxi, Emily G., Thomas, Ajit G., Rojas, Camilo, Moniruzzman, Mohammed, Slusher, Barbara S., Bergles, Dwight E., Calabresi, Peter A., Haughey, Norman J.   +11 more
openaire   +1 more source