Results 11 to 20 of about 91,612,173 (178)

The Neutral Sphingomyelinase 2 Is Required to Polarize and Sustain T Cell Receptor Signaling [PDF]

Frontiers in Immunology, 2018
By promoting ceramide release at the cytosolic membrane leaflet, the neutral sphingomyelinase 2 (NSM) is capable of organizing receptor and signalosome segregation. Its role in T cell receptor (TCR) signaling remained so far unknown. We now show that TCR-
Charlene Börtlein, Annette Draeger, Roman Schoenauer, Alexander Kuhlemann, Markus Sauer, Sibylle Schneider-Schaulies, Elita Avota   +6 more
doaj   +10 more sources

Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls [PDF]

International Journal of COPD, 2016
Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre,
Lea SR, Metcalfe HJ, Plumb J, Beerli C, Poll C, Singh D, Abbott-Banner KH   +6 more
doaj   +10 more sources

Staying sane in the membrane: Neutral sphingomyelinase 2 as a master regulator of plasma membrane ceramide [PDF]

Journal of Lipid Research
Ceramide, a key signaling sphingolipid in the plasma membrane, plays a pivotal role in fundamental cellular processes such as adhesion, polarity, and programmed cell death.
Zainuddin Quadri, Erhard Bieberich
doaj   +6 more sources

Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. [PDF]

ACS Chem Biol, 2020
We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propagation of tau pathology in the treatment of Alzheimer's disease (AD).
Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V.   +15 more
europepmc   +8 more sources

Role of Neutral Sphingomyelinase-2 (NSM 2) in the Control of T Cell Plasma Membrane Lipid Composition and Cholesterol Homeostasis [PDF]

Frontiers in Cell and Developmental Biology, 2019
The activity of neutral sphingomyelinase-2 (NSM2) to catalyze the conversion of sphingomyelin (SM) to ceramide and phosphocholine at the cytosolic leaflet of plasma membrane (PM) is important in T cell receptor (TCR) signaling.
Charlene Börtlein, Fabian Schumacher, Fabian Schumacher, Burkhard Kleuser, Lars Dölken, Elita Avota   +5 more
doaj   +2 more sources

Stress-induced sphingolipid signaling: role of type-2 neutral sphingomyelinase in murine cell apoptosis and proliferation. [PDF]

PLoS ONE, 2010
BACKGROUND:Sphingomyelin hydrolysis in response to stress-inducing agents, and subsequent ceramide generation, are implicated in various cellular responses, including apoptosis, inflammation and proliferation, depending on the nature of the different ...
Raphael Devillard, Sylvain Galvani, Jean-Claude Thiers, Jean-Louis Guenet, Yusuf Hannun, Jacek Bielawski, Anne Nègre-Salvayre, Robert Salvayre, Nathalie Augé   +8 more
doaj   +2 more sources

Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2 [PDF]

Journal of Lipid Research, 2012
Hyperosmolarity (HO) imposes a remarkable stress on membranes, especially in tissues in direct contact with the external environment. Our efforts were focused on revealing stress-induced lipid changes that precede the inflammatory cytokine response in ...
Alexandra Robciuc, Tuulia Hyötyläinen, Matti Jauhiainen, Juha M. Holopainen   +3 more
doaj   +6 more sources

Neutral sphingomyelinase-2 and cardiometabolic diseases. [PDF]

Obes Rev, 2021
SummarySphingolipids, in particular ceramides, play vital role in pathophysiological processes linked to metabolic syndrome, with implications in the development of insulin resistance, pancreatic ß‐cell dysfunction, type 2 diabetes, atherosclerosis, inflammation, nonalcoholic steatohepatitis, and cancer.
Sindhu S, Leung YH, Arefanian H, Madiraju SRM, Al-Mulla F, Ahmad R, Prentki M.   +6 more
europepmc   +4 more sources

Neutral sphingomyelinase 2 is required for HIV-1 maturation. [PDF]

Proc Natl Acad Sci U S A, 2023
HIV-1 assembly occurs at the inner leaflet of the plasma membrane (PM) in highly ordered membrane microdomains. The size and stability of membrane microdomains is regulated by activity of the sphingomyelin hydrolase neutral sphingomyelinase 2 (nSMase2) that is localized primarily to the inner leaflet of the PM.
Waheed AA, Zhu Y, Agostino E, Naing L, Hikichi Y, Soheilian F, Yoo SW, Song Y, Zhang P, Slusher BS, Haughey NJ, Freed EO.   +11 more
europepmc   +3 more sources

The neutral sphingomyelinase 2 in T cell receptor signaling and polarity

Biological Chemistry, 2018
Abstract By hydrolyzing its substrate sphingomyelin at the cytosolic leaflet of cellular membranes, the neutral sphingomyelinase 2 (NSM2) generates microdomains which serve as docking sites for signaling proteins and thereby, functions to regulate signal relay.
Lena, Collenburg, Sibylle, Schneider-Schaulies, Elita, Avota   +2 more
openaire   +3 more sources