Results 11 to 20 of about 8,475 (148)

Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes [PDF]

Journal of Lipid Research, 2023
Obesity-associated diabetes is linked to the accumulation of ceramide in various organs, including the liver. The exact mechanisms by which ceramide contributes to diabetic pathology are unclear, but one proposed scenario is that ceramide accumulation ...
S. El-Amouri, A. Karakashian, E. Bieberich, M. Nikolova-Karakashian   +3 more
doaj   +2 more sources

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV [PDF]

Neurobiology of Disease, 2022
People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population.
Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher   +13 more
doaj   +2 more sources

Inhibition of neutral sphingomyelinase 2 promotes remyelination. [PDF]

Sci Adv, 2020
Targeting a sphingomyelin hydrolase improves the structure of remyelinated fibers in a mouse model of multiple sclerosis.
Yoo SW, Agarwal A, Smith MD, Khuder SS, Baxi EG, Thomas AG, Rojas C, Moniruzzaman M, Slusher BS, Bergles DE, Calabresi PA, Haughey NJ.   +11 more
europepmc   +4 more sources

Targeting sphingolipid metabolism: inhibition of neutral sphingomyelinase 2 impairs coronaviral replication organelle formation [PDF]

mBio
Many plus-strand RNA viruses, including coronaviruses, orchestrate the formation of specialized replication organelles in the cytoplasm of infected cells by specific membrane-associated viral nonstructural proteins (nsp’s).
Florian Salisch, Fabian Schumacher, Ulrich Gärtner, Burkhard Kleuser, John Ziebuhr, Christin Müller-Ruttloff   +5 more
doaj   +2 more sources

Neutral Sphingomyelinase-2 (NSM 2) Controls T Cell Metabolic Homeostasis and Reprogramming During Activation [PDF]

Frontiers in Molecular Biosciences, 2020
Neutral sphingomyelinase-2 (NSM2) is a member of a superfamily of enzymes responsible for conversion of sphingomyelin into phosphocholine and ceramide at the cytosolic leaflet of the plasma membrane.
Maria Nathalia De Lira, Sudha Janaki Raman, Almut Schulze, Sibylle Schneider-Schaulies, Elita Avota   +4 more
doaj   +2 more sources

Neutral Sphingomyelinase 2 [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2011
Abstract Chronic obstructive pulmonary disease (COPD) is caused by exposure to cigarette smoke (CS). One mechanism of CS-induced lung injury is aberrant generation of ceramide, which leads to elevated apoptosis of epithelial and endothelial cells in the alveolar spaces.
Kent Pinkerton, Simone Filosto, Lisa Franzi   +2 more
exaly   +2 more sources

Dual Neutral Sphingomyelinase-2/Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. [PDF]

ACS Chem Biol, 2020
We report the discovery of a novel class of compounds that function as dual inhibitors of the enzymes neutral sphingomyelinase-2 (nSMase2) and acetylcholinesterase (AChE). Inhibition of these enzymes provides a unique strategy to suppress the propagation of tau pathology in the treatment of Alzheimer's disease (AD).
Bilousova T, Simmons BJ, Knapp RR, Elias CJ, Campagna J, Melnik M, Chandra S, Focht S, Zhu C, Vadivel K, Jagodzinska B, Cohn W, Spilman P, Gylys KH, Garg NK, John V.   +15 more
europepmc   +6 more sources

Neutral sphingomyelinase 2: A promising drug target for CNS disease. [PDF]

Adv Pharmacol
Neutral sphingomyelinase 2 (nSMase2), encoded by the SMPD3 gene, is a pivotal enzyme in sphingolipid metabolism, hydrolyzing sphingomyelin to produce ceramide, a bioactive lipid involved in apoptosis, inflammation, membrane structure, and extracellular vesicle (EV) biogenesis.
Huang M, Stremlau M, Zavras J, Zivko C, Thomas AG, Pietri P, Machairaki V, Slusher BS.   +7 more
europepmc   +3 more sources

The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. [PDF]

Int J Mol Sci
The accumulation of lipid droplets (LDs) and ceramides (Cer) is linked to non-alcoholic fatty liver disease (NAFLD), regularly co-existing with type 2 diabetes and decreased immune function. Chronic inflammation and increased disease severity in viral infections are the hallmarks of the obesity-related immunopathology.
Schempp R, Eilts J, Schöl M, Grijalva Yépez MF, Fekete A, Wigger D, Schumacher F, Kleuser B, van Ham M, Jänsch L, Sauer M, Avota E.   +11 more
europepmc   +3 more sources

Hyperosmolarity-induced lipid droplet formation depends on ceramide production by neutral sphingomyelinase 2 [PDF]

Journal of Lipid Research, 2012
Hyperosmolarity (HO) imposes a remarkable stress on membranes, especially in tissues in direct contact with the external environment. Our efforts were focused on revealing stress-induced lipid changes that precede the inflammatory cytokine response in ...
Alexandra Robciuc, Tuulia Hyötyläinen, Matti Jauhiainen, Juha M. Holopainen   +3 more
doaj   +6 more sources