Results 111 to 120 of about 91,612,173 (178)

Ceramide‐mediated orchestration of oxidative stress response through filopodia‐derived small extracellular vesicles

Journal of Extracellular Vesicles
Extracellular vesicles (EVs) are shed from the plasma membrane, but the regulation and function of these EVs remain unclear. We found that oxidative stress induced by H2O2 in Hela cells stimulated filopodia formation and the secretion of EVs.
Zainuddin Quadri, Ahmed Elsherbini, Simone M. Crivelli, Salim S. El‐Amouri, Priyanka Tripathi, Zhihui Zhu, Xiaojia Ren, Liping Zhang, Stefka D. Spassieva, Mariana Nikolova‐Karakashian, Erhard Bieberich   +10 more
doaj   +1 more source

ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation[S]

Journal of Lipid Research, 2016
Neutral sphingomyelinase-2 (nSMase2) is a key ceramide-producing enzyme in cellular stress responses. While many posttranslational regulators of nSMase2 are known, emerging evidence suggests a more protracted regulation of nSMase2 at the transcriptional ...
Christopher J. Clarke, Achraf A. Shamseddine, Joseph J. Jacob, Gabrielle Khalife, Tara A. Burns, Yusuf A. Hannun   +5 more
doaj   +1 more source

Primary cilia in stem cells and neural progenitors are regulated by neutral sphingomyelinase 2 and ceramide

Molecular Biology of the Cell, 2014
We show here that human embryonic stem (ES) and induced pluripotent stem cell–derived neuroprogenitors (NPs) develop primary cilia. Ciliogenesis depends on the sphingolipid ceramide and its interaction with atypical PKC (aPKC), both of which distribute to the primary cilium and the apicolateral cell membrane in NP rosettes.
He, Qian, Wang, Guanghu, Wakade, Sushama, Dasgupta, Somsankar, Dinkins, Michael, Kong, Ji Na, Spassieva, Stefka D., Bieberich, Erhard   +7 more
openaire   +2 more sources

Characterization of Neutral Sphingomyelinase Isoforms in Skeletal Muscle Mitochondria [PDF]

, 2020
Skeletal muscle is composed of fiber types that differ in mitochondrial content, antioxidant capacity, and susceptibility to apoptosis. Ceramides have been linked to apoptosis by increasing mitochondrial permeability, a common hallmark of apoptotic ...
Silvera, Sebastian
core   +1 more source

Adipocytes signal to recruit specific mRNAs from surrounding cells to restore expression deficits

Nature Communications
Extracellular vesicles (EVs) are nano-sized, membrane-delimited, particles released by cells that carry signaling macromolecules. A major pathway of EV production is potentiated by neutral sphingomyelinase 2 (SMPD3/nSMAse2), an enzyme that generates ...
Clair Crewe, Christy M. Gliniak, Toshiharu Onodera, Shiuhwei Chen, Jan-Bernd Funcke, May-Yun Wang, Snigdha Tiash, Yun-Ling Pai, Marjori Russo, Saket Awadhesbhai Patel, Ze Yu, Yi-Cian Zheng, Alex Larkin, Chao Xing, Laurent Gautron, Chun-Kan Chen, Chen Liu, Philipp E. Scherer   +17 more
doaj   +1 more source

Neutral sphingomyelinase 2 inhibitors based on the pyrazolo[1,5-a]pyrimidin-3-amine scaffold. [PDF]

Eur J Med Chem, 2023
Novotna K, Thomas AG, Stepanek O, Murphy B, Hin N, Skacel J, Mueller L, Tenora L, Pal A, Alt J, Wu Y, Paule J, Rais R, Slusher BS, Tsukamoto T.   +14 more
europepmc   +1 more source

Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound. [PDF]

Proc Natl Acad Sci U S A, 2023
Yoo SW, Waheed AA, Deme P, Tohumeken S, Rais R, Smith MD, DeMarino C, Calabresi PA, Kashanchi F, Freed EO, Slusher BS, Haughey NJ.   +11 more
europepmc   +1 more source

Interference of oxazoline derivatives with signaling pathways in ovarian and liver cancer cells.

, 2018
ER, endoplasmic reticulum; nSMase, neutral sphingomyelinase.
Aneta Rogalska (5563538), Arkadiusz Gajek (5563541), Agnieszka Marczak (5563550), Małgorzata Łukawska (5563544), Irena Oszczapowicz (5563547)   +4 more
core   +1 more source

Neutral sphingomyelinase 2 (nSMase2) is the primary neutral sphingomyelinase isoform activated by tumour necrosis factor-α in MCF-7 cells

, 2011
Activation of N-SMase (neutral sphingomyelinase) is an established part of the response of cytokines such as TNF (tumour necrosis factor)-α. However, it remains unclear which of the currently cloned N-SMase isoforms (nSMase1, nSMase2 and nSMase3) are ...
Yusuf A. Hannun, Emily A. Cloessner, Patrick L. Roddy, Christopher J. Clarke   +3 more
core   +1 more source

Virtual screening reveals aprepitant to be a potent inhibitor of neutral sphingomyelinase 2: implications in blockade of exosome release in cancer therapy. [PDF]

J Cancer Res Clin Oncol, 2023
Moloudizargari M, Hekmatirad S, Gharaghani S, Moghadamnia AA, Najafzadehvarzi H, Asghari MH.   +5 more
europepmc   +1 more source