Results 201 to 210 of about 54,402 (238)
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Neutrophil elastase and neutropenia
Blood, 2004HEMATOPOIESIS Neutrophil elastase ([NE] also called elastase-2 [ELA-2]) is a powerful serine protease stored in the primary granule of neutrophils.[1][1] This enzyme is synthesized primarily at the promyelocyte stage of neutrophil development in the bone marrow.
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Inhibitors of human neutrophil elastase
Expert Opinion on Therapeutic Patents, 1997Human neutrophil elastase (HNE) is a serine protease that is responsible for a number of diverse pathological conditions. Synthetic inhibitors which can regulate the in vivo activity of HNE will therefore have broad therapeutic applications. Over the past 15 years a diverse set of strategies have been pursued for the development of HNE inhibitors, the ...
Philip D Edwards, Chris A Veale
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Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment
2020Tumor-associated neutrophils (TANs) play a major role during cancer development and progression in the tumor microenvironment. Neutrophil elastase (NE) is a serine protease normally expressed in neutrophil primary granules. Formation of neutrophil extracellular traps (NETs), a mechanism used by neutrophils, has been traditionally associated with the ...
Hai, Huang +3 more
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Antithrombin inactivation by neutrophil elastase requires heparin
The American Journal of Medicine, 1989In certain thrombotic states, large declines in the levels of functional circulating antithrombin occur, which may reflect the highly active nature of the endothelial surface in suppressing excessive amounts of activated coagulation enzymes. Alternatively, we have recently observed an unexpected and paradoxical in vitro functioning of heparin that ...
R E, Jordan +5 more
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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis
Cell, 2021Kasturi Chakraborty +2 more
exaly
2011
The 2010 Biennial Meeting of the American Society for Matrix Biology (ASMB), Charleston, S.C., 24-27 October 2010.
Shum, DKY, Chan, SCH, Ip, SCH
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The 2010 Biennial Meeting of the American Society for Matrix Biology (ASMB), Charleston, S.C., 24-27 October 2010.
Shum, DKY, Chan, SCH, Ip, SCH
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NEUTROPHIL ELASTASES AND HAEMOLYTIC URAEMIC SYNDROME
The Lancet, 1989D, Milford +4 more
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