Results 31 to 40 of about 530,516 (247)

Lipopolysaccharides of Fusobacterium nucleatum and Porphyromonas gingivalis increase RANKL-expressing neutrophils in air pouches of mice

Laboratory Animal Research, 2021
Increases of neutrophils and osteoclasts are pathological changes of periodontitis. RANKL is an osteoclast differentiation factor. The effect of periodontopathogen LPS on RANKL-expressing neutrophils has not been clarified yet.
Ae Ri Kim, Yun Kyong Lim, Joong-Ki Kook, Eun-Jung Bak, Yun-Jung Yoo   +4 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Neutrophils in Leprosy

Frontiers in Immunology, 2019
Leprosy is an infectious disease caused by the intracellular bacillus Mycobacterium leprae that mainly affects the skin and peripheral nerves. One of the most intriguing aspects of leprosy is the diversity of its clinical forms.
Veronica Schmitz, Isabella Forasteiro Tavares, Patricia Pignataro, Alice de Miranda Machado, Fabiana dos Santos Pacheco, Jéssica Brandão dos Santos, Camila Oliveira da Silva, Euzenir Nunes Sarno   +7 more
doaj   +1 more source

Increased CD11b and Decreased CD62L in Blood and Airway Neutrophils from Long-Term Smokers with and without COPD

Journal of Innate Immunity, 2020
There is incomplete mechanistic understanding of the mobilization of neutrophils in the systemic and local compartment in smokers with chronic obstructive pulmonary disease (COPD).
Marit Stockfelt, Karin Christenson, Anders Andersson, Lena Björkman, Médea Padra, Bettina Brundin, Koustav Ganguly, Helga Asgeirsdottir, Sara Lindén, Ingemar Qvarfordt, Johan Bylund, Anders Lindén   +11 more
doaj   +1 more source

A persistent neutrophil-associated immune signature characterizes post–COVID-19 pulmonary sequelae [PDF]

, 2022
Peter M. George, Anna Reed, Sujal R. Desai, Anand Devaraj, Tasnim Shahridan Faiez, S. G. Laverty, Amama Kanwal, Camille Esneau, Michael K. P. Liu, Faisal Kamal, William D‐C Man, Sundeep Kaul, Suveer Singh, Georgia Lamb, Fatima K. Faizi, Michael Schuliga, Jane Read, Thomas Burgoyne, Andreia Pinto, Jake Micallef, Émilie Bauwens, Julie Candiracci, Mhammed Bougoussa, Mariëlle Herzog, Lavanya Raman, Blerina Ahmetaj‐Shala, Stuart Turville, Anupriya Aggarwal, Hugo Farne, Alessia Dalla Pria, Andrew Aswani, Francesca Patella, Weronika E. Borek, Jane A. Mitchell, Nathan W. Bartlett, Arran Dokal, Xiao‐Ning Xu, Peter Kelleher, Anand Shah, Aran Singanayagam   +39 more
openalex   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Generation of resolving memory neutrophils through pharmacological training with 4-PBA or genetic deletion of TRAM

Cell Death and Disease, 2022
Neutrophils are the dominant leukocytes in circulation and the first responders to infection and inflammatory cues. While the roles of neutrophils in driving inflammation have been widely recognized, the contribution of neutrophils in facilitating ...
RuiCi Lin, Ziyue Yi, Jing Wang, Shuo Geng, Liwu Li   +4 more
doaj   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Neutrophils Promote Tumor Progression in Oral Squamous Cell Carcinoma by Regulating EMT and JAK2/STAT3 Signaling Through Chemerin

Frontiers in Oncology, 2022
Oral squamous cell carcinoma (OSCC) is the most common malignancy of the oral cavity. In the tumor microenvironment, tumor-associated neutrophils (TANs) can promote tumor growth, invasion, and metastasis.
Xiaoyuan Hu, Xiaoyuan Hu, Fenggang Xiang, Fenggang Xiang, Yuanyong Feng, Yuanyong Feng, Fei Gao, Shengyou Ge, Shengyou Ge, Chengqin Wang, Chengqin Wang, Xuan Zhang, Ning Wang   +12 more
doaj   +1 more source