Results 11 to 20 of about 498,979 (245)
The Regulation of NF-κB Subunits by Phosphorylation
Cells, 2016 The NF-κB transcription factor is the master regulator of the inflammatory response and is essential for the homeostasis of the immune system. NF-κB regulates the transcription of genes that control inflammation, immune cell development, cell cycle ...
Frank Christian +2 more
doaj +2 more sources
NF-κB in inflammation and cancer. [PDF]
Cell Mol ImmunolNuclear factor-κB (NF-κB) is a family of transcription factors that transactivates genes associated with a wide range of biological processes, including immune responses, inflammation, cell growth and survival.
Mao H, Zhao X, Sun SC.
europepmc +2 more sources
NF-κB signaling in inflammation
Signal Transduction and Targeted Therapy, 2017 The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune functions and serves as a pivotal mediator of inflammatory responses.
Ting Liu +3 more
semanticscholar +1 more source
Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
Signal Transduction and Targeted Therapy, 2020 NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is activated by various stimuli, transducing a quick but transient transcriptional activity, to regulate the expression of various proinflammatory genes and also serve as
Hui Yu +4 more
semanticscholar +1 more source
The complexity of NF-κB signaling in inflammation and cancer
Molecular Cancer, 2013 The NF-κB family of transcription factors has an essential role in inflammation and innate immunity. Furthermore, NF-κB is increasingly recognized as a crucial player in many steps of cancer initiation and progression. During these latter processes NF-κB
B. Hoesel, J. Schmid
semanticscholar +1 more source
Understanding NF‐κB signaling via mathematical modeling
Molecular Systems Biology, 2008 Mammalian inflammatory signaling, for which NF‐κB is a principal transcription factor, is an exquisite example of how cellular signaling pathways can be regulated to produce different yet specific responses to different inflammatory insults. Mathematical
Raymond Cheong +2 more
doaj +1 more source
Kaohsiung Journal of Medical Sciences, 2012 Modulation of nuclear factor-kappa B (NF-κB) expression has important clinical implications including anti-inflammation. Recently, we have shown that direct regulation of NF-κB/p65 subunit may account for tacrolimus ointment’s remarkable clinical ...
Ching-Shuang Wu +5 more
doaj +1 more source
Translational Psychiatry, 2021 Bipolar disorder and schizophrenia have multiple clinical and genetic features in common, including shared risk associated with overlapping susceptibility loci in immune-related genes. Higher activity of the nuclear factor-κB (NF-κB) transcription factor
Kaitlyn M. Roman +3 more
doaj +1 more source
The Role of Ubiquitination in NF-κB Signaling during Virus Infection
Viruses, 2021 The nuclear factor κB (NF-κB) family are the master transcription factors that control cell proliferation, apoptosis, the expression of interferons and proinflammatory factors, and viral infection. During viral infection, host innate immune system senses
Kun Song, Shitao Li
doaj +1 more source
A role for NF-κB activity in skin hyperplasia and the development of keratoacanthomata in mice. [PDF]
PLoS ONE, 2013 Previous studies have implicated NF-κB signaling in both cutaneous development and oncogenesis. However, these studies have been limited in part by the lethality that results from extreme over- or under-expression of NF-κB in available mouse models. Even
Brian Poligone +5 more
doaj +1 more source